Nucleus incertus contribution to hippocampal theta rhythm generation

Núñez, Ángel; Cervera‐Ferri, Ana; Olucha-Bordonau, Francisco E.; Ruiz‐Torner, Amparo; Teruel, Vicent

doi:10.1111/j.1460-9568.2006.04797.x

Cited by 101 publications

(116 citation statements)

References 42 publications

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“…These subnuclei send efferent fibers containing serotonergic REM-off neurons to the MnR and DRN and efferent fibers containing cholinergic REM-on neurons to the LDTg (3,9,11,27). In addition, the IPc and IPl subnuclei send efferent fibers to the NI (8, 9, 11), which relays ascending projections from the nucleus pontis oralis to the medial septal nucleus, a pathway implicated in hippocampal theta generation (14). Moreover, the IP sends a small number of efferent fibers to the hippocampus and medial septal nucleus (9,11).…”

Section: Discussionmentioning

confidence: 99%

“…The IP is located on the midline in the ventral region of the midbrain-hindbrain transition and is evolutionarily conserved from fish to mammals. It has reciprocal connections with the median raphe nucleus (MnR), dorsal raphe nucleus (DRN), laterodorsal tegmental nucleus (LDTg), and nucleus incertus (NI) (8)(9)(10)(11)(12)(13), which are implicated in the regulation of sleep and wakefulness and the generation of hippocampal theta waves (2,3,14,15). In addition, the IP receives input from the basal forebrain via the fasciculus retroflexus directly or relayed at the medial habenular nucleus.…”

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confidence: 99%

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Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato

Sato²,

Sinton³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Sleep and wakefulness are regulated primarily by inhibitory interactions between the hypothalamus and brainstem. The expression of the states of rapid eye movement (REM) sleep and non-REM (NREM) sleep also are correlated with the activity of groups of REM-off and REM-on neurons in the dorsal brainstem. However, the contribution of ventral brainstem nuclei to sleep regulation has been little characterized to date. Here we examined sleep and wakefulness in mice deficient in a homeobox transcription factor, Goosecoid-like (Gscl), which is one of the genes deleted in DiGeorge syndrome or 22q11 deletion syndrome. The expression of Gscl is restricted to the interpeduncular nucleus (IP) in the ventral region of the midbrain-hindbrain transition. The IP has reciprocal connections with several cell groups implicated in sleep/wakefulness regulation. Although Gscl −/− mice have apparently normal anatomy and connections of the IP, they exhibited a reduced total time spent in REM sleep and fewer REM sleep episodes. In addition, Gscl −/− mice showed reduced theta power during REM sleep and increased arousability during REM sleep. Gscl −/− mice also lacked the expression of DiGeorge syndrome critical region 14 (Dgcr14) in the IP. These results indicate that the absence of Gscl and Dgcr14 in the IP results in altered regulation of REM sleep.homeobox transcription factor | mouse behavior | ventral brainstem

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato

Sato²,

Sinton³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…As the supramammillary area is also a prominent target of RLN3 fibers from the nucleus incertus , it is presumed that the nucleus incertus can modulate the broader septohippocampal system, not only through ascending projections, but also by modulating the entire loop of ascending supramammillary-septo-hippocampal and descending entorhinal-septal-supramammillary projections. Observations that both electrical stimulation of the nucleus incertus (Nunez et al, 2006) and direct injection of an RXFP3 agonist into the medial septal area (Ma et al, 2009b) induce hippocampal theta are suggestive of a synergistic action of GABA and RLN3 on theta rhythm generation.…”

Section: Implications For Understanding Medial Septum Functionmentioning

confidence: 99%

“…We subsequently demonstrated that stimulation of nucleus incertus in urethane-anesthetized rats increased theta and decreased delta activity of the hippocampus, whereas, electrolytic lesion of the nucleus incertus abolished hippocampal theta induced by stimulation of the nucleus reticularis pontis oralis (RPO) (Nunez et al, 2006), a key brainstem generator of hippocampal theta rhythm (Vertes, 1981;Vertes, 1982;Nuñez et al, 1991;Vertes et al, 1993b;Vertes and Kocsis, 1997). The hippocampal area in which field potentials were recorded receives only sparse inputs from the nucleus incertus, and it was concluded that the influence of the nucleus incertus on hippocampal theta rhythm was most likely mediated by its effects within the medial septum and/or other lower brain structures.…”

Section: Introductionmentioning

confidence: 99%

Distribution and targets of the relaxin‐3 innervation of the septal area in the rat

Olucha-Bordonau¹,

Otero-García²,

Sánchez-Pérez³

et al. 2012

J of Comparative Neurology

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Neural tracing studies have revealed that the rat medial and lateral septum are targeted by ascending projections from the nucleus incertus, a population of tegmental GABA neurons. These neurons express the relaxin‐family peptide, relaxin‐3, and pharmacological modulation of relaxin‐3 receptors in medial septum alters hippocampal theta rhythm and spatial memory. In an effort to better understand the basis of these interactions, we have characterized the distribution of relaxin‐3 fibers/terminals in relation to different septal neuron populations identified using established protein markers. Dense relaxin‐3 fiber plexuses were observed in regions of medial septum containing hippocampal‐projecting choline acetyltransferase (ChAT)‐, neuronal nitric oxide synthase (nNOS)‐, and parvalbumin (PV)‐positive neurons. In lateral septum (LS), relaxin‐3 fibers were concentrated in the ventrolateral nucleus of rostral LS and the ventral nucleus of caudal LS, with sparse labeling in the dorsolateral and medial nuclei of rostral LS, dorsal nucleus of caudal LS, and ventral portion nuclei. Relaxin‐3 fibers were also observed in the septofimbrial and triangular septal nuclei. In the medial septum, we observed relaxin‐3‐immunoreactive contacts with ChAT‐, PV‐, and glutamate decarboxylase‐67‐positive neurons that projected to hippocampus, and contacts between relaxin‐3 terminals and calbindin‐ and calretinin‐positive neurons. Relaxin‐3 colocalized with synaptophysin in nerve terminals in all septal areas, and ultrastructural analysis revealed these terminals were symmetrical and contacted spines, somata, dendritic shafts, and occasionally other axonal terminals. These data predict that this GABA/peptidergic projection modulates septohippocampal activity and hippocampal theta rhythm related to exploratory navigation, defensive and ingestive behaviors, and responses to neurogenic stressors. J. Comp. Neurol. 520:1903–1939, 2012. © 2011 Wiley Periodicals, Inc.

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“…Another well-described input to the SUM originates in the nucleus incertus (NI) and targets differently the SUMl and SUMm such that the NI compact part sends a prominent input to the SUMm and sparse input to the SUMl, whereas for the NI diffuse part the opposite is true (Goto et al, 2001); the NI also sends a prominent projection to the HPF including the dentate gyrus (Goto et al, 2001). Functionally, it is noteworthy that the SUM and NI have a role in the modulation of the hippocampal theta rhythm (Bland, 1986;Kocsis and Vertes, 1994;Vertes and Kocsis, 1997;Kirk, 1998;Pan and McNaughton, 2004;Nunez et al, 2006). …”

mentioning

confidence: 99%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems-motor, sensory, cognitive, and behavioral state -included in a basic structure-function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire. INDEXING TERMShypothalamus; periaqueductal gray; hippocampal formation; behavior; motivation An emerging view of the lateral hypothalamic area (LHA) reveals a highly regionally differentiated neuronal architecture with correspondingly differentiated axonal connections characterized by an extensive divergent and convergent topographic organization (Swanson, 2004;Goto et al., 2005;Swanson et al., 2005;Hahn, 2010;Hahn and Swanson, 2010). Such an organization calls for an equivalently extensive comparative analysis of the underlying organization of the severally parceled LHA (16 provisional LHA regions within the hypothalamic lateral zone) (Swanson, 2004). In a previous article (Hahn and Swanson, 2010), we presented the results of a high-resolution analysis of the axonal inputs and outputs of the lateral hypothalamic area (LHA) juxtaparaventricular (LHAjp) and suprafornical (LHAs) regions-two differentiations of the hypothalamic lateral zone middle group within NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript respectively a medial (LHAjp) and perifornical (LHAs) tier of a recently revised parcellation for the LHA (Swanson, 2004;Swanson et al., 2005).The previous work showed that the LHAjp and LHAs have interregional connections with several hundred distinct gray matter regions encompassing all four subsystems (motor, sensory, cognitive, and...

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Nucleus incertus contribution to hippocampal theta rhythm generation

Cited by 101 publications

References 42 publications

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Distribution and targets of the relaxin‐3 innervation of the septal area in the rat

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

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