In the present study, a novel model was established to investigate the enhanced heat transfer to turbulent pipe flow of supercritical pressure fluids. The governing equations for the steady turbulent compressible pipe flow were simplified into the one-dimensional nondimensionalized forms based on the boundary layer theory. A conventional mixing length turbulence model for constant-property pipe flows was modified by introducing the effect of density fluctuations into the equations of turbulent transport, and the modified turbulence model was applicable to both constant-property and variable-property pipe flows. With the suggested model, which was a combination of the nondimensional governing equations and the modified turbulence model, the numerical calculations were carried out for the turbulent convective heat transfer of water in round tubes at supercritical pressures. The results showed that the present model can provide a relatively precise prediction about the effect of pressure, mass flux, and wall heat flux on heat transfer for supercritical fluid flows and greatly reduce the calculation workload. The modified turbulence model showed a much better agreement with the experimental results than the original turbulence model.