Numerical Simulation in Aortic Arch Aneurysm

Matsuzawa, Teruo; Gao, Feng; Qiao, Aike; Ohta, Osamu; Okada, Hiroshi

doi:10.5772/18566

Cited by 5 publications

(2 citation statements)

References 42 publications

(40 reference statements)

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“…The aortic arch is complex for its curvature in three dimensions, and the aneurysm enlarges the local diameter of the aortic arch. According to fluid dynamic theory, the bend of the arch generates a secondary flow [43,44]. The secondary flow occurs due to the velocity difference between the lesser and greater curvature of the arch and thus the difference of centrifugal forces when the blood flows through the aortic arch.…”

Section: Discussionmentioning

confidence: 99%

“…With respect to the aneurysm, for its growth deviation from the main flow direction, an adverse pressure gradient arises near the neck of the aneurysm, which gives birth to a vortex [22,44,45], and results in the slow speed of blood flow. Additionally, the longer resident time of blood particles in this region (Case B) provides another formative factor for the risky areas.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Postoperative Remodeling Characteristics after Modular Inner Branched Stent-Graft Treatment of Aortic Arch Pathologies Using Computational Fluid Dynamics

Zhu

Song

et al. 2023

Bioengineering

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The modular inner branched stent-graft (MIBSG), a novel interventional therapy, has demonstrated good effects in the endovascular treatment of aortic arch pathologies, especially those involving the supra-aortic branches. Nevertheless, the long-term efficacy of the MIBSG and in-depth quantitative evaluation of postoperative outcomes remain to be examined. Moreover, the regularity of postoperative vascular remodeling induced by MIBSG implantation has yet to be explored. To address these questions, we constructed four models (normal, preoperative, 1 week postoperative, and 6 months postoperative) based on a single patient case to perform computational fluid dynamics simulations. The morphological and hemodynamic characteristics, including the velocity profile, flow rate distribution, and hemodynamic parameter distribution (wall shear stress and its derivative parameters), were investigated. After MIBSG implantation, the morphology of the supra-aortic branches changed significantly, and the branch point moved forward to the proximal ascending aorta. Moreover, the curvature radius of the aortic arch axis continued to change. These changes in morphology altered the characteristics of the flow field and wall shear stress distribution. As a result, the local forces exerted on the vessel wall by the blood led to vessel remodeling. This study provides insight into the vascular remodeling process after MIBSG implantation, which occurs as a result of the interplay between vascular morphological characteristics and blood flow characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%