Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources

Panetta, Daniele; Labate, L.; Billeci, Lucia; Lascio, Nicole Di; Esposito, Giuseppina; Faita, Francesco; Mettivier, Giovanni; Palla, D.; Pandola, L.; Pisciotta, Pietro; Russo, Giorgio; Sarno, Antonio; Tomassini, P.; Salvadori, Piero A.; Gizzi, L. A.; Russo, Paolo

doi:10.1038/s41598-019-44779-y

Cited by 9 publications

(4 citation statements)

References 69 publications

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“…The commercial product was later installed at the Munich Compact Light Source and has since been used for micro-CT imaging, propagation and gratingbased XPC imaging, and K-edge subtraction imaging [81]. Alternative CLS designs have been presented by other groups [82], and it has been shown in simulations that CLSs may provide an ideal solution for in vivo dynamic imaging in small animals [83].…”

Section: Phase Contrast Micro-ctmentioning

confidence: 99%

Advances in micro-CT imaging of small animals

Clark

Badea

2021

Physica Medica

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Micron-scale computed tomography (micro-CT) imaging is a ubiquitous, cost-effective, and non-invasive three-dimensional imaging modality. We review recent developments and applications of micro-CT for preclinical research. Methods: Based on a comprehensive review of recent micro-CT literature, we summarize features of state-of-theart hardware and ongoing challenges and promising research directions in the field. Results: Representative features of commercially available micro-CT scanners and some new applications for both in vivo and ex vivo imaging are described. New advancements include spectral scanning using dual-energy micro-CT based on energy-integrating detectors or a new generation of photon-counting x-ray detectors (PCDs). Beyond two-material discrimination, PCDs enable quantitative differentiation of intrinsic tissues from one or more extrinsic contrast agents. When these extrinsic contrast agents are incorporated into a nanoparticle platform (e.g. liposomes), novel micro-CT imaging applications are possible such as combined therapy and diagnostic imaging in the field of cancer theranostics. Another major area of research in micro-CT is in x-ray phase contrast (XPC) imaging. XPC imaging opens CT to many new imaging applications because phase changes are more sensitive to density variations in soft tissues than standard absorption imaging. We further review the impact of deep learning on micro-CT. We feature several recent works which have successfully applied deep learning to micro-CT data, and we outline several challenges specific to micro-CT. Conclusions: All of these advancements establish micro-CT imaging at the forefront of preclinical research, able to provide anatomical, functional, and even molecular information while serving as a testbench for translational research.

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Section: Phase Contrast Micro-ctmentioning

confidence: 99%

Advances in micro-CT imaging of small animals

Clark

Badea

2021

Physica Medica

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“…Measured proton cut-off energy was consistently found to be in agreement with published scaling laws [3,4] . Moreover, measurements of LWFA were also carried out for development of a platform for radiobiological studies of very high-energy electrons (VHEEs) [10] and high-temporalresolution medical imaging [30] .…”

Section: Beam Pointing Stabilitymentioning

confidence: 99%

Overview and specifications of laser and target areas at the Intense Laser Irradiation Laboratory

Gizzi

Labate

Baffigi

et al. 2021

High Pow Laser Sci Eng

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We present the main features of the ultrashort, high-intensity laser installation at the Intense Laser Irradiation Laboratory (ILIL) including laser, beam transport and target area specifications. The laboratory was designed to host laser–target interaction experiments of more than 220 TW peak power, in flexible focusing configurations, with ultrarelativistic intensity on the target. Specifications have been established via dedicated optical diagnostic assemblies and commissioning interaction experiments. In this paper we give a summary of laser specifications available to users, including spatial, spectral and temporal contrast features. The layout of the experimental target areas is presented, with attention to the available configurations of laser focusing geometries and diagnostics. Finally, we discuss radiation protection measures and mechanical stability of the laser focal spot on the target.

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“…An ultrashort X-ray pulse will completely eliminate the image blurring effect of organ movement. This property has been exploited in a proposal for laser based propagation phase contrast CT for cardiological imaging in small animal models [22].…”

mentioning

confidence: 99%

Towards high-sensitivity and low-dose medical imaging with laser x-ray sources

Stutman

Safca

Tomassini

et al. 2023

Compact Radiation Sources From EUV to Gamma-Rays: Development and Applications

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Phase contrast X-ray imaging can be much more sensitive to soft tissue lesions than conventional absorption contrast X-ray imaging, being a potential game changer for medical imaging. A phase contrast method well suited for clinical implementation is the grating interferometry. We show that by using μm period multi-meter long interferometers one can strongly increase the phase sensitivity and lower the dose towards soft tissue imaging applications such mammography. Conventional X-ray tubes do not provide, however, sufficient X-ray flux for clinical imaging with such long interferometers. Instead, 100-TW class lasers could produce highly directional and intense X-ray sources ideal for high sensitivity medical interferometry. We present the X-ray source characteristics required for clinical interferometry, advantages and disadvantages of betatron versus inverse Compton scattering sources for clinical application, and some practical considerations towards laser based interferometric medical imaging.

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Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources

Cited by 9 publications

References 69 publications

Advances in micro-CT imaging of small animals

Advances in micro-CT imaging of small animals

Overview and specifications of laser and target areas at the Intense Laser Irradiation Laboratory

Towards high-sensitivity and low-dose medical imaging with laser x-ray sources

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