Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis

Aslam, Asadullah; Bello, Jibril Oyekunle; Bhatti, Kamran Hassan; Philipraj, Joseph; Sissoko, Ibrahim; Vasconcellos, Giovanna Souza; Trinchieri, Alberto; Buchholz, Noor

doi:10.1007/s00240-020-01182-x

Cited by 16 publications

(13 citation statements)

References 108 publications

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“…Spring , and Taraxacum officinale L. to treat UL has been reported ( Supplementary Table S1 ). These types of plants contain bioactive compounds such as flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids, which can have a positive effect on UL due to their antimicrobial, litholytic, antispasmodic, diuretic, antioxidant, and anti-inflammatory properties, which promote a reduction in urinary saturation by inhibiting crystallization, nucleation, and crystal aggregation [ 34 ] ( Table 1 ).…”

Section: Plants Used In Mexican Traditional Medicine Against Urolithi...mentioning

confidence: 99%

“…Thus, this lack of information is a limitation of the knowledge of the mechanism of action of these medicinal plants. The presence of several bioactive compounds in these plants may be responsible for their beneficial effects [ 34 , 61 ]. A few of the main compounds contained in their chemical composition are flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids.…”

Section: Molecular Mechanism Of Bioactive Compounds Present In Medici...mentioning

confidence: 99%

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Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

et al. 2022

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Urolithiasis (UL) involves the formation of stones in different parts of the urinary tract. UL is a health problem, and its prevalence has increased considerably in developing countries. Several regions use plants in traditional medicine as an alternative in the treatment or prevention of UL. Mexico has known about the role of traditional medicine in the management of urinary stones. Mexican traditional medicine uses plants such as Argemone mexicana L., Berberis trifoliata Hartw. ex Lindl., Costus mexicanus Liebm, Chenopodium album L., Ammi visnaga (L.) Lam., Eysenhardtia polystachya (Ortega) Sarg., Selaginella lepidophylla (Hook. & Grev.) Spring, and Taraxacum officinale L. These plants contain different bioactive compounds, including polyphenols, flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids, which could be effective in preventing the process of stone formation. Evidence suggests that their beneficial effects might be associated with litholytic, antispasmodic, and diuretic activities, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The molecular mechanisms involving these effects could be related to antioxidant, anti-inflammatory, and antimicrobial properties. Thus, the review aims to summarize the preclinical evidence, bioactive compounds, and molecular mechanisms of the plants used in Mexican traditional medicine for the management of UL.

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Section: Plants Used In Mexican Traditional Medicine Against Urolithi...mentioning

confidence: 99%

Section: Molecular Mechanism Of Bioactive Compounds Present In Medici...mentioning

confidence: 99%

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

et al. 2022

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“…After every episode, the subsequent relapse rate increases and the recurrence time interval decreases. 1 , 9 Modern therapeutic aids like extracorporeal shock wave lithotripsy (ESWL) and drug treatment have revolutionized the clinical practice but cannot reduce the recurrence of urolithiasis and also have unwanted effects. ESWL may cause renal impairment, hypertension and hemorrhage.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Evaluation of Mentha piperita Against Urolithiasis: An In Vitro and In Vivo Study

Jamshed

Jabeen

2022

Dose-Response

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Background: Mentha piperita L. (peppermint) is one of the most widely consumed medicinal herbs that has gained attention from food and pharmaceutical industries due to its distinct aroma and taste. Purpose: Present study was aimed to rationalize the traditional use of peppermint in urolithiasis and to explore its possible underlying mechanism. Research Design: The aqueous methanolic crude extract of Mentha piperita (Mp.Cr) was assessed for phytochemical constituents and antioxidant activity. In vitro crystallization assays were performed to determine the inhibitory effects of Mp.Cr against crystal nucleation, aggregation and growth. In vivo urolithiasis model was developed in rats by the administration of ammonium chloride and ethylene glycol in drinking water. The antiurolithic effects of Mp.Cr were evaluated by analyzing kidney homogenate, biochemical and histological parameters. Results: HPLC analysis showed the presence of epicatechin, quercetin, gallic acid, syringic acid, kaempferol, caffeic acid and coumaric acid. The maximum quantity of quercetin equivalent flavonoid and gallic acid equivalent phenolic content was found to be 63.73 ± .24 mg QE/g and 43.76 ± .6 mg GAE/g of Mp.Cr, respectively. Mp.Cr significantly normalized urinary and serum biochemistry, similar to the standard cystone treatment. Conclusions: The current study validated the preventive and curative potential of Mp.Cr against urolithiasis and justified its traditional use in kidney stone disease.

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“…A previous analysis showed that people who form kidney stones were characterized by microbial dysbiosis, including an abnormal abundance of eubacteria, archaea, eukaryotes and even fungi. In addition to O. formigenes , research to date has also indicated the insufficiency of Ruminococcus and Oscillospira as causes of abnormal oxalate homeostasis in the gut [ 66 ]. A metagenomics analysis showed that the fecal microbiomes of stone formers exhibited reduced biodiversity and numbers.…”

Section: Oxalobacter Formigenesmentioning

confidence: 99%

“…Moreover, high Sutterella , Veillonella , and Peptococcus abundance were significantly correlated with urinary oxalate excretion [ 64 ]. Another study showed that changes in the microbiome which may contribute to the onset of kidney stones were associated with a depletion of Lacttobacillus and an increased amount of pathogenic Enterobacteriaceae [ 66 ].…”

Section: Oxalobacter Formigenesmentioning

confidence: 99%

Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

Wigner

Bijak

Saluk‐Bijak

2022

Cells

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Nephrolithiasis ranks third among urological diseases in terms of prevalence, making up about 15% of cases. The continued increase in the incidence of nephrolithiasis is most probably due to changes in eating habits (high protein, sodium, and sugar diets) and lifestyle (reduced physical activity) in all developed countries. Some 80% of all kidney stones cases are oxalate urolithiasis, which is also characterized by the highest risk of recurrence. Frequent relapses of nephrolithiasis contribute to severe complications and high treatment costs. Unfortunately, there is no known effective way to prevent urolithiasis at present. In cases of diet-related urolithiasis, dietary changes may prevent recurrence. However, in some patients, the condition is unrelated to diet; in such cases, there is evidence to support the use of stone-related medications. Interestingly, a growing body of evidence indicates the potential of the microbiome to reduce the risk of developing renal colic. Previous studies have primarily focused on the use of Oxalobacterformigenes in patients with urolithiasis. Unfortunately, this bacterium is not an ideal probiotic due to its antibiotic sensitivity and low pH. Therefore, subsequent studies sought to find bacteria which are capable of oxalate degradation, focusing on well-known probiotics including Lactobacillus and Bifidobacterium strains, Eubacterium lentum, Enterococcus faecalis, and Escherichia coli.

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Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis

Cited by 16 publications

References 108 publications

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

Pharmacological Evaluation of Mentha piperita Against Urolithiasis: An In Vitro and In Vivo Study

Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

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