Nutrition status mediates the association between cognitive decline and sarcopenia

Xia, Xin; Hu, Fayun; Hou, Lisha; Jia, Shuli; Liu, Yixin; Deng, Linghui; Zhang, Yan; Zhao, Wenchuan; Zhang, Gongchang; Yue, Jirong; Dong, Birong

doi:10.18632/aging.202672

Cited by 7 publications

(3 citation statements)

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“…2017[445]) and was registered in the Chinese Clinical Trial Registry (ChiCTR1800018895). The design and study protocol of WCHAT have been reported elsewhere [14,15]. In brief, WCHAT was initiated in 2018, and adopted multi-stage random cluster sampling in four provinces in west China, Yunnan, Guizhou, Sichuan and Xinjiang.…”

Section: Study Design and Data Collectionmentioning

confidence: 99%

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

Sun

Harris

Hou

et al. 2022

Euro J of Neurology

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Background and purpose: Motoric cognitive risk (MCR) syndrome characterized by subjective cognitive complaints and slow gait has been proposed and validated as a pre-dementia syndrome. The overall and specific ethnic prevalence of MCR and the associated factors are poorly understood in middle-aged to older community-dwelling residents in west China. Methods:The present study included 6091 samples from the prospective cohort study, West China Health and Aging Trend (WCHAT). Multidimensional factors of demography, lifestyle, social support, anthropometrics and body components, and clinical status were investigated and analyzed by univariate and multivariate logistic regression models. Lasso regression and K-fold cross-validation were conducted to construct the most predictive model with fitted factors. Results:The overall prevalence of MCR was 9.74%, and ethnically the prevalence was 14.25% in Tibetan, 11.03% in Yi, 10.72% in Han, 5.18% in Uighur and 4.55% in Qiang, respectively. In the adjusted models, the positively associated risk factors included diabetes mellitus (odds ratio [OR] = 1.51, p = 0.007), osteoarthritis (OR = 1.50, p = 0.002), depression (OR = 1.36, p = 0.005), poor sleep (OR = 1.21, p = 0.045), comorbidity (OR = 1.49, p = 0.001) and falls in the last 12 months (OR = 1.34, p = 0.031). Of note, every 1-unit increase of value in stroke was associated with an approximate 3-fold higher risk of having MCR, whilst in high-density lipoprotein with a 30% lower risk of MCR,respectively.Conclusions: Profiles of MCR from the aspects of ethnicity and the presenium stage need further exploration. It is a promising strategy to apply MCR as a primary prevention tool to prevent dementia. | 1355 MOTORIC COGNITIVE RISK SYNDROME IN MULTIPLE ETHNICS INTRODUC TI ON An estimated 55 million people are currently living with dementia globally [1], with forecasts reaching 78 million by 2030 and 152 million by 2050, 60%-80% of which can be attributed to Alzheimer's disease (AD) [1-3]. The Alzheimer's Disease International estimated that 75% of individuals with dementia are not diagnosed and 90% of them are in undeveloped and underdeveloped regions and countries [1]. Dementia is a disease with multifactorial etiology and heterogeneous clinical presentation and disease trajectory. Also, dementia has a long preclinical phase from several years to decades before the cognitive alterations indicating mild cognitive impairment (MCI) are detectable [3,4]. Motoric cognitive risk (MCR) syndrome was proposed and validated in 2013 by Verghese and colleagues to identify aging individuals at high risk for dementia during the pre-dementia stage [5,6]. Approximately 10% of older persons are affected by MCR worldwide [7]. This syndrome integrates two specific harbingers of dementia, subjective cognitive complaints (SCC) and slow gait speed (SG), in the absence of mobility disability and dementia [5,6]. MCR was found to be more strongly associated with cognitive decline or dementia than either of these two harbingers alone [3,8]. Cognitive fun...

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Section: Study Design and Data Collectionmentioning

confidence: 99%

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

Sun

Harris

Hou

et al. 2022

Euro J of Neurology

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“…Xiaolei et al also indicated that nutritional status mediates the association between cognitive decline and sarcopenia. Thus, they propose that sustaining a favorable nutritional status can postpone the adverse impacts of cognitive decline and consequently the incidence of sarcopenia [64].…”

Section: Discussionmentioning

confidence: 99%

Unlocking Cognitive Potential: Association of Sarcopenia and Mediterranean Diet on Cognitive Function in Community-Dwelling Elderly of the Dalmatian Region

Jelaska,

Vučković,

Gugić Ordulj

et al. 2024

Nutrients

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The aim of this study was to determine the association between muscle strength, adherence to the Mediterranean diet (MeDi) and cognitive function in community-dwelling elderly. General data, data of body composition and anthropometric parameters, clinical and laboratory findings, cognitive test questionnaires (Mini-Mental State Examination—MMSE, Trail Making Test—TMT, Symbol Digit Modalities Test—SDMT), and nutritional assessments (Mini Nutritional Assessment—MNA, Mediterranean Diet Serving Score—MDSS) were obtained for each study participant. Handgrip strength (HS) was used as one of the key parameters for defining probable sarcopenia, among the Short Physical Performance Battery test (SPPB) (for defining physical activity) and the strength, assistance with walking, rising from a chair, climbing stairs, and falls questionnaire (SARC-F). Our cross-sectional study involved 114 participants aged ≥ 60 years, and two-thirds of the participants were female (76.3% vs. 23.7%). Probable sarcopenia was found in 34.7% of them. Using bivariate regression analysis, cognitive deficit among the sarcopenic population was associated with the following groups of collected data: (a) sociodemographic-associated factors—advanced age (OR: 1.07; p = 0.004), single marital status (OR: 3.25; p = 0.03), and low level of education (OR: 0.22; p < 0.003); (b) behavioral-associated factors—duration of institutionalization (OR: 1.05; p = 0.007), performance of heavy physical work (OR: 6.26; p = 0.001), low physical activity (OR: 0.08; p = 0.002), and risk of malnutrition (OR: 3.87; p = 0.005); (c) disease-related factors—loss of appetite (OR: 2.24; p = 0.04), information processing speed (OR: 0.88; p < 0.001), blood pressure systolic/diastolic variables (OR: 0.96/0.96; p = 0.002/0.02), medications (OR: 1.19; p = 0.005), predictive sarcopenia score ≥ 4 (OR: 3.1; p = 0.003), and low muscle strength (OR: 0.92; p = 0.002). Cognitive preservation among the sarcopenic population was associated with married status (OR: 0.23; p = 0.20), a high level of education (OR: 0.18; p = 0.002), smoking (OR: 0.33; p = 0.02), high physical activity (OR: 0.07; p < 0.001), and dietary habits using poultry (OR: 0.12; p = 0.004). The results suggest a significant association between sarcopenia and cognitive function in community-dwelling elderly, highlighting the need for regular nutritional interventions in this special population.

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“…Notably, the present study not only extended existing evidence but further highlighted the association between depression and sarcopenia in middle-aged adults, thereby further strengthening the possible application of our observation to a wider range of population. With respect to nutritional factors, though the link between diet and sarcopenia has been more widely studied, mainly focusing on nutritional status and specific nutrients ( 30 ), little is known about the role of dietary inflammatory potential, presenting a distinct biological mechanism. Our results suggested that the pro-inflammatory diet, indicated by a higher DII score, was related to a greater odd of sarcopenia and its component of muscle mass.…”

Section: Discussionmentioning

confidence: 99%

Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses

2022

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BackgroundSarcopenia is a major public health problem. Depressive symptoms and dietary inflammatory potential play important roles in the development of sarcopenia. We aimed to disentangle the relationships between depressive symptoms, dietary inflammatory potential, and sarcopenia.MethodsA total of 6,082 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Sarcopenia was defined according to the Foundation for the National Institutes for Health (FNIH) criteria. The Depressive symptoms were assessed using the nine-item Patient Health Questionnaire (PHQ-9). Dietary Inflammatory Index (DII) was calculated based on 24-h dietary recall interview. Two sets of mediation models were constructed separately.ResultsDepressive symptoms and DII were associated with sarcopenia, with odds ratios [ORs] (95% CIs) 2.54 (1.27, 5.13) and 1.17 (1.00, 1.37), respectively. DII score mediated the association of depressive symptoms with low muscle mass, explaining a total of 10.53% of the association (indirect effect = 0.004). Depressive symptoms had a significant mediating effects on the association between DII with low muscle mass, explaining a total of 12.50% of the association (indirect effect = 0.001).ConclusionsOur findings suggested that both depressive symptoms and dietary inflammatory potential had direct effects, and indirect effects on low muscle mass, handgrip strength, muscle mass, through each other. It provides important insights into integrated nutritional and psychological intervention strategies in preventing sarcopenia.

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Nutrition status mediates the association between cognitive decline and sarcopenia

Cited by 7 publications

References 40 publications

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

Unlocking Cognitive Potential: Association of Sarcopenia and Mediterranean Diet on Cognitive Function in Community-Dwelling Elderly of the Dalmatian Region

Relationships Between Depressive Symptoms, Dietary Inflammatory Potential, and Sarcopenia: Mediation Analyses

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