Nutritional Importance and Pharmacological Activity of Mangifera Indica

Khushtar, Mohd

doi:10.20959/wjpps20175-8974

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…The pulp, bark, leaf, fruit peel, heartwood, and seed of M. indica have numerous medicinal uses 32 for treatment of a wide range of human diseases including diarrhea, cough, anemia, gastric disorders, jaundice, malaria, hepatic disorders, hemorrhage, diabetes, and ulcers 33 .…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Pseudomonas aeruginosa quorum sensing by methyl gallate from Mangifera indica

Naga,

Zaki,

El-Badan

et al. 2023

Sci Rep

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Antipathogenic drugs are a potential source of therapeutics, particularly following the emergence of multiple drug-resistant pathogenic microorganisms in the last decade. The inhibition of quorum sensing (QS) is an advanced antipathogenic approach for suppression of bacterial virulence and dissemination. This study aimed to investigate the inhibitory effect of some Egyptian medicinal plants on the QS signaling system of Pseudomonas aeruginosa. Among the tested plants, Mangifera indica exhibited the highest quorum sensing inhibition (QSI) activity against Chromobacterium violaceum ATCC 12472. Four pure compounds were extracted and identified; of these, methyl gallate (MG) showed the most potent QSI. MG had a minimum inhibitory concentration (MIC) of 512 g/mL against P. aeruginosa strains PAO1, PA14, Pa21, Pa22, Pa23, Pa24, and PAO-JP2. The virulence factors of PAO1, PA14, Pa21, Pa22, Pa23, and Pa24 were significantly inhibited by MG at 1/4 and 1/2 sub-MICs without affecting bacterial viability. Computational insights were performed by docking the MG compound on the LasR receptor, and the QSI behavior of MG was found to be mediated by three hydrogen bonds: Trp60, Arg61, and Thr75. This study indicates the importance of M. indica and MG in the inhibition and modulation of QS and QS-related virulence factors in P. aeruginosa.

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Section: Discussionmentioning

confidence: 99%