Nutritional properties of the triglycerides of saturated fatty acids of medium chain‐length

Abstract

SummaryThe influence of a purified rat diet containing 20 or 33% of the saturated medium chain‐length triglycerides (MCT) with and without linoleic acid supplements on growth, caloric requirements for weight maintenance and weight increase, fertility, lactation performance, and serum cholesterol levels was compared with that of similar diets containing lard, coconut oil, or no fat.Among male rats maintained on diets containing 20% lard or 20% MCT and .09% linoleic acid for 18 months no differences were observed between the groups other than the depressed body weight and lowered serum cholesterol levels of the group fed MCT. When groups of male rats were kept at constant weight by the daily restricted feeding of diets containing lard, MCT, or coconut oil or no fat plus 2% linoleic acid, the weight‐maintenance requirements of the group fed MCT were higher than of those on lard and coconut oil and even somewhat higher than the requirements of the animals fed the fat‐free diet. The requirements for weight increase over those for maintenance were 0.9 g. per gram increase for all diets. Additional linoleic acid in the MCT diet decreased the weight and maintenance differences between groups fed MCT and lard.The lactation performance of mothers on MCT plus .09% linoleic acid was poor. The second generation animals initially showed signs of more severe linoleic acid deficiency which however disaappeared without linoleic acid supplements.Some cholesterol levels of animals on MCT were significantly below those of groups on lard. Addition of linoleic acid to the MCT diet did not change the results.

Enzymatic Synthesis of Capric Acid-Rich Structured Lipids (MUM type) Using Candida antarctica Lipase

“…MCTs have also been reported to act as antioxidants and reduce tissue requirements for vitamin E 6 . The anti-coagulation effect of MCTs helps to prevent artherosclerosis 7 .…”

Effect of Randomly Interesterified Triacylglycerols Containing Medium- and Long-Chain Fatty Acids on Energy Expenditure and Hepatic Fatty Acid Metabolism in Rats

“…Compared with long-chain fatty acids (LCFA), MCFA have several unique physiological and biological characteristics, as reported elsewhere over the past half-century. [1][2][3] Medium-chain triacylglycerols (MCT), composed exclusively of MCFA, are metabolized differently from long-chain triacylglycerols (LCT), composed exclusively of LCFA. MCFA are absorbed via the portal system and are transported to the liver directly, whereas LCT are absorbed via the intestinal lymphatic ducts and transported as chylomicrons through the thoracic duct to reach systemic circulation.…”

Long-term effect of medium-chain trigly-ceride on hepatic enzymes catalyzing lipogenesis and cholesterogenesis in rats.

“…The metabolism of MCT by the liver is different from that of long-chain triglyceride in that most of which is ingested is rapidly cata bolized into CO2 and ketone bodies (2,3). Therefore, the clinical application of MCT will be of considerable importance in the prevention of the hyperlipi demia (2,4,5) as well as in the avoidance of the undesirable consequences of overweight (6). The present study was undertaken to investigate the nutritional influence of MCT on lipid metabolism, focusing particularly on the key enzymes catalyzing cholesterogenesis and lipogenesis in the rat liver.…”