2002
DOI: 10.1016/s1472-6483(12)60023-6
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O-4. Nuclear abnormalities in a series of 6733 human oocytes

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Cited by 5 publications
(3 citation statements)
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“…The potential of preselecting of euploid embryos for transfer is in agreement with the fact that more than half of oocytes and embryos tested in PGD for poor prognosis IVF patients were shown to be with chromosomal abnormalities [Gianaroli et al, 2001; Munne, 2002; Kuliev et al, 2003]. Therefore, PGD for chromosomal aneuploidy allows avoiding from transfer of at least 50% of embryos, which are abnormal and should clearly contribute to the pregnancy outcome of the IVF patients of advanced reproductive age.…”
Section: Indications For Pgdmentioning
confidence: 56%
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“…The potential of preselecting of euploid embryos for transfer is in agreement with the fact that more than half of oocytes and embryos tested in PGD for poor prognosis IVF patients were shown to be with chromosomal abnormalities [Gianaroli et al, 2001; Munne, 2002; Kuliev et al, 2003]. Therefore, PGD for chromosomal aneuploidy allows avoiding from transfer of at least 50% of embryos, which are abnormal and should clearly contribute to the pregnancy outcome of the IVF patients of advanced reproductive age.…”
Section: Indications For Pgdmentioning
confidence: 56%
“…Finally, the patients should be also informed about the high aneuploidy rates in oocytes and embryos, as well as about the prevalence of mosaicism at the cleavage stage [Gianaroli et al, 2001; Munne, 2002; Kuliev et al, 2003]. In this way they may choose testing for aneuploidy at least for the chromosome, in which the causative gene tested is mapped, which may be of special value in PGD for single gene disorders offered for patients of the advanced reproductive age.…”
Section: Accuracy Of Pgdmentioning
confidence: 99%
“…Diese sind zum überwiegenden Teil auf chromosomale Veränderungen der Gameten zurückzuführen. Die Bedeutung der Polkörperdiagnostik bei älteren Frauen im Kinderwunschklientel wird klar, wenn man berücksich-tigt, dass nur 2-4% der Spermien eine Chromosomenaberration aufweisen, aber bis zu 40% der Eizellen von solchen genetischen Veränderungen betroffen sind und letzteres sehr stark altersabhängig ist [3, 11, [23][24][25][26][27][28][29][30][31][32][33] …”
Section: Jahrgang / Heft 21-22 · 2005 30 November 2005unclassified