“…Although there is controversy about their meaning, electron microscope studies have revealed that these aged cells, grouped like the younger cells and derived from the cytotrophoblast, remain scattered on the surface of the villi. Mesquita et al (2003) and Correa et al (2008) indicated that the increasing number of syncytial nuclei, associated with necrosis of the villi, fibrin deposits, and calcification foci, would be part of the physiological aging process of the placenta, causing an increase during hypertensive syndrome. Therefore, this phenomenon is characterized by the increase in the features established by Tenney & Parker, resulting in a process of uteroplacental hypoxia, as in the cases of eclampsia, or a process of fetoplacental hypoxia, as happens in the cases of thrombosis of the fetal arteries.…”