Oat phenolic compounds regulate metabolic syndrome in high fat diet-fed mice via gut microbiota

Dong, Lezhen; Qin, Chuan; Li, Ying; Wu, Zufang; Liu, Lianliang

doi:10.1016/j.fbio.2022.101946

Cited by 61 publications

(43 citation statements)

References 33 publications

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“…High‐fat diet induces the formation of free radicals in mice, results in lipid peroxidation and higher oxidative stress, and consequently causes inflammation. With the supplementation of rice bran high in phenolics in WFRN, oxidative stress and the damage of hepatocytes could be alleviated (Dong et al., 2022).…”

Section: Resultsmentioning

confidence: 99%

Whole‐grain flat rice noodles improve lipid metabolism in high‐fat‐diet‐fed mice in association with gut microbiota

Luo

Yuan

et al. 2023

Int J of Food Sci Tech

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Summary Brown rice‐based foods are thought to be effective in preventing obesity. In this study, the effect of whole‐grain flat rice noodles (WFRN) on lipid metabolism as well as their relationship with gut microbiota was investigated in mice fed a high‐fat diet (HFD). The results indicated that WFRN reduced the degree of obesity, the lipid levels in the liver and serum, and the risk of liver inflammation. Moreover, WFRN significantly increased the contents of total short‐chain fatty acids (SCFAs) (from 162.06 ± 29.79 to 272.97 ± 59.26 μg mL−1; P < 0.05) and reshaped the composition of gut microbiota in mice cecum. As the beneficial bacteria with boosted abundance, higher Coriobacteriaceae_UCG‐002 was negatively related to the lipid levels in the liver and serum, and positively correlated with the content of hexanoic acid. On the contrary, the lower abundance of harmful bacteria Staphylococcus was positively correlated to body fat and inversely related to isovaleric acid, and Helicobacter was positively associated with higher serum LDL‐C and lower hexanoic acid. This study suggested that WFRN played a positive role in ameliorating lipid accumulation and inflammation caused by obesity, and this effect was closely associated with the regulation of gut microbiota and SCFAs.

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Section: Resultsmentioning

confidence: 99%

Whole‐grain flat rice noodles improve lipid metabolism in high‐fat‐diet‐fed mice in association with gut microbiota

Luo

Yuan

et al. 2023

Int J of Food Sci Tech

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show abstract

“…HB is rich and abundant in β-glucan, dietary fibers, protein, phenolic ingredients, and amino acids, and these compounds serve important roles in the hypolipidemic function of HB [ 13 , 19 , 24 ]. However, the effects and mechanisms of MHB on the regulation of hyperlipidemia, hepatic protection, intestinal flora disorders, and fecal metabolites induced by HFCD remain to be studied.…”

Section: Discussionmentioning

confidence: 99%

Modified Highland Barley Regulates Lipid Metabolism and Liver Injury in High Fat and Cholesterol Diet ICR Mice

Zhou

2022

Foods

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Highland barley (Hordeum vulgare L. HB) has been demonstrated to have a series of dietotherapy values, including being low fat, low sugar, high fiber, and especially high in β-glucan. Long-term consumption could reduce the incidence of chronic diseases and metabolic syndromes. In this study, the regulating effect of modified highland barley (MHB) products, namely microwave fluidized HB, extruded and puffed HB, and ultrafine pulverized HB on lipid metabolism and liver injury in mice fed a high fat and cholesterol diet (HFCD) was investigated using microbiota diversity gene sequencing and untargeted metabolomics. A total of six groups of mice were supplemented with a normal diet or an HFCD, with or without MHB, and the experimental period lasted 10 weeks. The obtained results demonstrated that MHB supplementation could effectively reverse the increase in body weight gain and adipose tissue accumulation caused by an HFCD (p < 0.05). Moreover, serum biochemical parameters showed that MHB supplementation significantly decreased total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels, while increasing high-density lipoprotein cholesterol (HDL-C) levels. The results of hematoxylin and eosin (H&E) assays showed that MHB supplementation could significantly improve the liver injury and adipose tissue accumulation. In addition, 16S rRNA amplicon sequencing showed that MHB supplementation increased the bacteroidetes/firmicutes ratio and the abundance Lactobacillus abundance, while also decreasing the Proteobacteria abundance, which are bacteria closely associated with the hyperlipidemia caused by HFCD. LC-MS metabolomics indicated that MHB supplementation significantly enhanced the levels of Deoxycholic acid, Myclobutanil, 3-Epiecdysone, 3,4-Dihydroxybenzeneacetic acid, and so on. In addition, MHB supplementation promoted activation of the Arachidonic acid metabolism pathways, the expression of ABC transporters, bile secretion, primary bile acid biosynthesis, and so on. Above all, this study showed the potential capacity of MHB to relieve hyperlipidemia and provides a reference for developing a new dietary intervention supplement to ameliorate hyperlipidemia.

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“…Factors associated with significant weight gain over the past few decades include unhealthy dietary habits, including inadequate fruit and vegetable consumption, frequent consumption of energy-dense snack foods, meal skipping, and eating out, especially in younger adults [ 5 ]. Obesity is associated with increasing disease burden, including metabolic syndromes, type 2 diabetes, cardiovascular disease, nonalcoholic steatohepatitis, chronic kidney disease, site-specific cancers, musculoskeletal disorders, and premature death [ 6 , 7 , 8 ]. The cornerstone of body weight management is lifestyle-based therapy, which combines a tailored reduced-calorie diet, physical activity, and behavioral counseling [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Hormonal Gut–Brain Signaling for the Treatment of Obesity

Roh

Choi

2023

IJMS

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The brain, particularly the hypothalamus and brainstem, monitors and integrates circulating metabolic signals, including gut hormones. Gut–brain communication is also mediated by the vagus nerve, which transmits various gut-derived signals. Recent advances in our understanding of molecular gut–brain communication promote the development of next-generation anti-obesity medications that can safely achieve substantial and lasting weight loss comparable to metabolic surgery. Herein, we comprehensively review the current knowledge about the central regulation of energy homeostasis, gut hormones involved in the regulation of food intake, and clinical data on how these hormones have been applied to the development of anti-obesity drugs. Insight into and understanding of the gut–brain axis may provide new therapeutic perspectives for the treatment of obesity and diabetes.

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Oat phenolic compounds regulate metabolic syndrome in high fat diet-fed mice via gut microbiota

Cited by 61 publications

References 33 publications

Whole‐grain flat rice noodles improve lipid metabolism in high‐fat‐diet‐fed mice in association with gut microbiota

Whole‐grain flat rice noodles improve lipid metabolism in high‐fat‐diet‐fed mice in association with gut microbiota

Modified Highland Barley Regulates Lipid Metabolism and Liver Injury in High Fat and Cholesterol Diet ICR Mice

Hormonal Gut–Brain Signaling for the Treatment of Obesity

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