Obesity: A Risk Factor for Severe Acute Biliary and Alcoholic Pancreatitis

Suazo-Barahona, Jorge; Carmona-Sánchez, Ramón; Robles-Dı́az, Guillermo; Milke-Garcı́a, Pilar; Vargas-Voráckóva, Florencia; Uscanga-Domı́nguez, Luis; Peláez-Luna, Mario

doi:10.1111/j.1572-0241.1998.442_l.x

Cited by 100 publications

(27 citation statements)

References 25 publications

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“…Concerning the etiology, in this study, acute biliary pancreatitis accounted for 47.5% of all cases which is in line with results of earlier reports [8, 9]. Moreover, it was not surprising that alcohol was not a leading cause of acute pancreatitis, reflecting the fact that the level of alcohol consumption of 4.89 liters per capita in China was much lower when compared with 10.29 liters per capita in industrialized countries [10].…”

Section: Discussionsupporting

confidence: 79%

Acute Pancreatitis in the Guangdong Province, China

et al. 2007

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Background/Aims: Many studies have recently been published on acute pancreatitis; however, few large-sample studies have been focused on the risk factors for deaths in severe acute pancreatitis. To address this issue, the present study was intended to assess etiology, severity, and mortality of acute pancreatitis in the Guangdong Province (Guangdong), China, and to analyze the risk factors responsible for deaths in severe acute pancreatitis in this large series of patients. Methods: Four tertiary medical centers located in Guangdong were involved in this retrospective study. Data of 2,342 patients with acute pancreatitis admitted to these centers from December 1990 through December 2005 were collected in a standardized form and analyzed. Results: Of the 2,342 patients (1,130 men and 1,212 women, mean age 51±18, range 4–98 years), 1,778 (76.0%) had mild pancreatitis, and 564 (24.0%) had the severe form. Biliary tract disease (47.5%) was the predominant etiology, the overall mortality rate was 5.0%, and the fatality rate in patients with severe acute pancreatitis was 20.0%. Among the deceased patients in the severe acute pancreatitis group, logistic regression analysis of variables showed that the independent risk factor for mortality was shock, while a biliary origin was a protective factor against a poor prognosis. Conclusions: In this case series, the results suggest that biliary tract disease was the main etiologic factor of acute pancreatitis in Guangdong. The majority of deaths in severe acute pancreatitis occurred within the first 14 days of admission; the only independent risk factor for mortality was systematic complication of shock.

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Section: Discussionsupporting

confidence: 79%

Acute Pancreatitis in the Guangdong Province, China

et al. 2007

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“…Hypertriglyceridemia is crucially involved in obesity, which increases the risk of lung, rectal, and thyroid cancer. Clinical studies have clearly shown that obesity leads to increased severity of acute pancreatitis [8][9][10][11], and obesity appears to confer an increased risk of pancreatic cancer [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Profiling of Serum from Human Pancreatic Cancer Patients Using 1H NMR Spectroscopy and Principal Component Analysis

Ouyang

Huang

et al. 2011

Appl Biochem Biotechnol

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Pancreatic cancer is a malignant tumor with the worst prognosis among all cancers. At the time of diagnosis, surgical cure is no longer a feasible option for most patients, thus early detection of pancreatic cancer is crucial for its treatment. Metabolomics is a powerful new analytical approach to detect the metabolome of cells, tissue, or biofluids. Here, we report the application of (1)H nuclear magnetic resonance (NMR) combined with principal components analysis to discriminate pancreatic cancer patients from healthy controls based on metabolomic profiling of the serum. The metabolic analysis revealed significant lower of 3-hydroxybutyrate, 3-hydroxyisovalerate, lactate, and trimethylamine-N-oxide as well as significant higher level of isoleucine, triglyceride, leucine, and creatinine in the serum from pancreatic cancer patients compared to that of healthy controls. Our data demonstrate that the subtle differences in metabolite profiles in serum of pancreatic cancer patients and that of healthy subjects as a result of physiological and pathological variations could be identified by NMR-based metabolomics and exploited as metabolic markers for the early detection of pancreatic cancer.

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“…As an independent prognostic factor for the worse outcome of AP, obesity has been considered to be related with a higher incidence of SAP, local and systemic complications, and higher mortality rates; however, these studies have flaws. One of the studies included in a previous meta-analysis had defined obesity as a BMI >25, which was different from their inclusion criteria [12]. In addition, 3 new prospective studies were published after the recent meta-analysis in 2006.…”

Section: Discussionmentioning

confidence: 99%