Obesity alters circadian behavior and metabolism in sex dependent manner in the volcano mouse Neotomodon alstoni

Carmona‐Alcocer, Vania; Fuentes-Granados, Citlalli; Carmona-Castro, Agustín; Aguilar-González, Ivette; Cárdenas-Vázquez, René; Miranda‐Anaya, Manuel

doi:10.1016/j.physbeh.2011.09.022

Cited by 27 publications

(28 citation statements)

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“…In order to explore whether Neotomodon offspring had a body weight increase similar to that of the wild mice observed before [40], we followed a group of mice born in captivity until the 7 th month. Figure 1A illustrates the average body weight (BW) gain after weaning (n = 10 each group) for lean and obese F1 mice.…”

Section: Resultsmentioning

confidence: 99%

“…Mice between 50 and 60 g were not considered in this study. Obesity was characterized according to previous work [40] where obese mice were 50% heavier than lean mice and also presented elevated blood concentrations of leptin, insulin, triacylglycerides and basal glucose. In the present study, we also compared the amount of epididymal fat, and the change of size in organs such as the liver, and kidney (Figure 1B).…”

Section: Methodsmentioning

confidence: 99%

“…Activity in a non-wheel running environment was continuously monitored using a light beam detection system and collected with data acquisition software (ACTBIO, UNAM, Mexico) as described elsewhere [40]. Each beam interruption was considered a single event.…”

Section: Methodsmentioning

confidence: 99%

“…It is particularly useful to understand whether the altered mechanisms in obesity occur regardless of the model used, or if they are a consequence of the specific method used to induce obesity [38]. The endemic Mexican volcano mouse, Neotomodon alstoni, is an advantageous model for a variety of behavioral and physiological studies, including circadian rhythms and its relation to obesity [394041] and hypothalamic integration of food intake [42]. In this context, a mouse such as N. alstoni offers a different perspective, since some of these mice develop obesity with standard rodent diets, while others remain lean.…”

Section: Introductionmentioning

confidence: 99%

“…As they grow, almost half of the population – either wild-captured or F1 offspring – becomes progressively overweight and eventually obese after 4–6 months. The body weight of these obese specimens is almost twice that of lean mice, indicating a probable biological predisposition for overweight in some sector of the population [39, 40]. In the present study, we present the differences in circadian phase shift, from lean and obese N. alstoni born in vivarium conditions and we address the mechanisms of such differences by studying the photoinduction of c-Fos synthesis in the SCN, as observed by others [8, 23] as well as in the presence of VIP [33, 34].…”

Section: Introductionmentioning

confidence: 99%

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Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Miranda‐Anaya¹,

Luna-Moreno²,

Carmona-Castro³

et al. 2017

Journal of Circadian Rhythms

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Obesity is a growing problem worldwide with a clear impact on health status. It is also a condition that negatively affects circadian rhythms. When the mouse Neotomodon alstoni is fed a regular rodent chow, some individuals develop obesity, representing an opportunity to compare the effects of spontaneous obesity upon the circadian organization in this species with that observed in other rodents with induced obesity. We report differences in the free running circadian locomotor activity rhythm and in the effects of light pulses between lean and obese mice. Also, the photo-induced expression of the c-Fos protein and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN) were examined at circadian time (CT) 14 and 22. We show that obese mice have a larger dispersion of the period of circadian locomotor rhythm in constant darkness. Photic induced phase shifts are nearly 50% shorter at CT 14, and 50% larger at CT 22 than in lean mice. The photoinduction of VIP in the SCN at CT 22 was larger in obese mice, which may be related to the differences observed in photic phase shifting. Our work indicates that the obesity in Neotomodon has effects on the neural mechanisms that regulate the circadian system.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Miranda‐Anaya¹,

Luna-Moreno²,

Carmona-Castro³

et al. 2017

Journal of Circadian Rhythms

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Melanin‐concentrating hormone peptidergic system: Comparative morphology between muroid species

Diniz

Battagello

Cherubini

et al. 2019

J of Comparative Neurology

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Melanin-concentrating hormone (MCH) is a conserved neuropeptide, predominantly located in the diencephalon of vertebrates, and associated with a wide range of functions. While functional studies have focused on the use of the traditional mouse laboratory model, critical gaps exist in our understanding of the morphology of the MCH system in this species. Even less is known about the nontraditional animal model Neotomodon alstoni (Mexican volcano mouse). A comparative morphological study among these rodents may, therefore, contribute to a better understanding of the evolution of the MCH peptidergic system. To this end, we employed diverse immunohistochemical protocols to identify key aspects of the MCH system, including its spatial relationship to another neurochemical population of the tuberal hypothalamus, the orexins. Three-dimensional (3D) reconstructions were also employed to convey a better sense of spatial distribution to these neurons. Our results show that the distribution of MCH neurons in all rodents studied follows a basic plan, but individual characteristics are found for each species, such as the preeminence of a periventricular group only in the rat, the lack of posterior groups in the mouse, and the extensive presence of MCH neurons in the anterior hypothalamic area of Neotomodon. Taken together, these data suggest a strong anatomical substrate for previously described functions of the MCH system, and that particular neurochemical

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Mechanisms of Circadian Systems in Animals and Their Clinical Relevance

Aguilar‐Roblero¹,

Dı́az-Muñoz²,

Fanjul‐Moles³

2015

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Obesity alters circadian behavior and metabolism in sex dependent manner in the volcano mouse Neotomodon alstoni

Cited by 27 publications

References 50 publications

Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice (Neotomodon alstoni)

Melanin‐concentrating hormone peptidergic system: Comparative morphology between muroid species

Mechanisms of Circadian Systems in Animals and Their Clinical Relevance

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