Obesity-Related Genetic Variants and Hyperuricemia Risk in Chinese Men

Abstract

Objective: Obesity/metabolic syndrome and hyperuricemia are clinically associated; however, the association of obesity/metabolic syndrome-related genetic variants with hyperuricemia is not clear. Therefore, we assessed this association in Chinese men diagnosed with hyperuricemia in comparison to a non-hyperuricemia group. Methods: We genotyped 47 single nucleotide polymorphisms (SNPs) previously identified to be associated with obesity or metabolic syndrome in 474 adult males (aged ≥ 18 years) using multiplex polymerase chain reaction. Multivariate logistic regression was used to investigate the association between the genetic variations and hyperuricemia. Stratified analyses were applied to further assess the associations. Results: The obesity-related SNP in MSRA rs545854 significantly affected serum uric acid levels. In addition, the G-allele of rs545854 was positively associated with the risk of hyperuricemia [odds ratio (OR) = 2.80, 95% confidence interval (CI) = 1.19–6.64, P = 0.0188]. After adjusting the model for body mass index and central obesity, rs545854 was shown to be an independent factor increasing the risk of hyperuricemia (OR = 2.81, 95%CI = 1.18–6.70, P = 0.0196). Stratified analyses also showed a significant association between rs545854 and hyperuricemia among meat eaters (OR = 2.62, 95%CI = 1.09–6.26, P = 0.0308). Conclusion: The obesity-related SNP rs545854 was correlated with the serum uric acid level and risk of hyperuricemia in a male Chinese population. Therefore, men carrying this SNP could benefit from limiting their meat consumption to prevent hyperuricemia. These findings suggest an underlying genetic link between obesity and hyperuricemia worthy of further exploration.

Asymptomatic Hyperuricemia and Metabolically Unhealthy Obesity: A Cross-Sectional Analysis in the Tianning Cohort

“… 8 In humans, an obesity-related genetic variant (rs545854) was associated with serum UA levels and the susceptibility to hyperuricemia. 9 Obesity at childhood was associated with an elevated level of serum UA at young adulthood. 10 However, the precise mechanisms contributing to elevation of uric acid in individuals with obesity are not very clear.…”

Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota

“…Thus, MsrA in tissues rather than the gut microbiota is a main contributor to sulindac activation. The association of genetic polymorphisms of human MSRA with obesity, diabetes, and coronary artery disease (Hotta et al, 2010;Yeung et al, 2011;Gu et al, 2013;Ma et al, 2019) has been reported, although studies assessing the impact of individual mutations on the enzymatic activity and/or expression of MSRA remain to be performed. It is worth investigating whether sulindac has excess or insufficient pharmacological effects in patients with MSRA variants.…”

The Rise of ST-Elevation Myocardial Infarction in Women of Northeast China

“…Significantly, hyperuricemia was related to diabetes and high LDL-C in women only. Ma et al (2019) used multiplex polymerase chain reaction to genotype 47 SNPs already associated with obesity and MetS and discovered some were also associated with uric acid levels. The team adjusted for body mass index and central obesity and found the MSRA polymorphism rs545854 was an independent factor for the risk of HUA (OR = 2.81, 95% CI = 1.18–6.70, p = .0196).…”

“…HUA and obesity together are associated with a significant risk of HTN (Tian et al, 2019). Ma et al (2019) assessed 8,331 participants in four groups in Liaoning province: normal body mass without HUA; obese (BMI > 25) without HUA; normal body mass with hyperuricemia; and obese with HUA. The obese-HUA group had a significantly elevated risk of HTN (OR 2.98 [95% CI: 2.48–3.57]) while the risk for those with HUA alone was barely altered (OR 1.14 [95% CI: 0.92–1.42]).…”