Obesity, Tamoxifen Use, and Outcomes in Women With Estrogen Receptor-Positive Early-Stage Breast Cancer

Dignam, James J.; Wieand, Kelly; Johnson, Karen A.; Fisher, Bernard; Xu, Lei; Mamounas, Eleftherios P.

doi:10.1093/jnci/djg060

Cited by 212 publications

(205 citation statements)

References 77 publications

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“…Higher BMI has been related to more advanced stages of breast cancer at diagnosis in terms of tumour size [38]. Obesity appears not to interfere with the efficacy of tamoxifen in women with lymph-node negative, oestrogen receptor-positive breast cancer [39].…”

Section: Biological Mechanismmentioning

confidence: 99%

Lifestyle changes and breast cancer prognosis: a review

Kellen

Vansant

Christiaens

et al. 2008

Breast Cancer Res Treat

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Section: Biological Mechanismmentioning

confidence: 99%

Lifestyle changes and breast cancer prognosis: a review

Kellen

Vansant

Christiaens

et al. 2008

Breast Cancer Res Treat

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“…Several studies (Dignam et al, 2003;Berclaz et al, 2004;Loi et al, 2005) reported a higher risk of death in patients with BMI above 30 compared to those with a BMI less than 25. Furthermore, results from the Nurses' Health Study (Kroenke et al, 2005) showed that the association of weight gain after breast cancer diagnosis and increased breast cancer mortality was limited among women who had normal weight (BMI<25) before diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Association of Nutritional Status with Quality of Life in Breast Cancer Survivors

Mohammadi¹,

Sulaiman²,

Koon³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Nutritional status and dietary intake play a significant role in the prognosis of breast cancer and may modify the progression of disease. The aim of this study was to determine the influence of nutritional status on the quality of life of Iranian breast cancer survivors. Cross-sectional data were collected for 100 Iranian breast cancer survivors, aged 32 to 61 years, attending the oncology outpatient clinic at Golestan Hospital, Ahvaz, Iran. Nutritional status of subjects was assessed by anthropometric measurements, Patient-Generated Subjective Global Assessment (PG-SGA) and three non-consecutive 24-hour diet recalls. The European Organization of Research and Treatment of Cancer Quality of Life form (EORTC QLQ-C30) was used to assess quality of life. Ninety-four percent of the survivors were well-nourished, 6% were moderately malnourished or suspected of being malnourished while none were severely malnourished. Prevalence of overweight and obesity was 86%. Overall, participants had an inadequate intake of vitamin D, E, iron and magnesium according to dietary reference intake (DRI) recommendations. Survivors with better nutritional status had better functioning scales and experienced fewer clinical symptoms. It appears important to provide educational and nutritional screening programs to improve cancer survivor quality of life.

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“…These reviews report that roughly two-thirds of the studies conducted in the last decade have shown that higher body mass index (BMI) or body weight (overweight or obesity) are significant risk factors for recurrent disease or decreased survival [1;3;4], with only 25% showing a null effect and 10% suggesting a significant inverse association [3]. However, two recent randomized clinical trials, which offer the advantages of large populations in which clinical prognostic factors are well defined, have found an effect of obesity only on overall survival [5] or only on new contralateral breast disease, but not recurrence [6]. Several plausible mechanisms have been proposed to support the effect of body weight on breast cancer growth.…”

Section: Introductionmentioning

confidence: 99%

Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

Caan

Emond

Natarajan

et al. 2006

Breast Cancer Res Treat

132

121

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PURPOSE: To examine whether weight gain after diagnosis of breast cancer affects the risk of breast cancer recurrence.PATIENT AND METHODS: Patients included 3215 women diagnosed with early stage breast cancer (Stage I > 1 cm., II, and IIIA) who were enrolled either in an observational cohort of breast cancer survivors or were part of the comparison group of a dietary intervention trial to prevent breast cancer recurrence. We computed weight change from 1 yr prior to diagnosis to study enrollment. Delayed entry Cox proportional hazards models were used to evaluate associations of categories of weight change with time to recurrence, controlling for known prognostic factors.RESULTS: Neither moderate (5-10%) nor large (>10%) weight gain (HR 0.8, 95%CI, 0.6 to 1.1; HR 0.9, 95% CI, 0.7 to 1.2, respectively) after breast cancer diagnosis was associated with an increased risk of breast cancer recurrence in the early years post diagnosis (median time of 73.7 months from diagnosis). CONCLUSION: Our research provides evidence that weight gain commonly seen in the first several years following a breast cancer diagnosis does not increase a woman's risk for breast cancer recurrence in the first 5-7 years post diagnosis. However, this research does not address the effects of weight gain on overall survival or on the risk of other new cancers, other prognostic outcomes of concern to the breast cancer survivor.

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Obesity, Tamoxifen Use, and Outcomes in Women With Estrogen Receptor-Positive Early-Stage Breast Cancer

Cited by 212 publications

References 77 publications

Lifestyle changes and breast cancer prognosis: a review

Lifestyle changes and breast cancer prognosis: a review

Association of Nutritional Status with Quality of Life in Breast Cancer Survivors

Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

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