Objective Analysis of Age-Related Changes in the Superficial Musculoaponeurotic System in Japanese Females Using Computed Tomography

Abstract

Background The superficial musculoaponeurotic system (SMAS) is an anatomical structure involved in facial aging. Objectives This study focused on SMAS thickness, and aimed to establish age-related changes in SMAS thickness. Methods A total of 100 adult Japanese female participants (aged 20–79 years) were enrolled in the study. The participants were divided into 3 age groups: Y, M, and E, comprising 20 to 39, 40 to 59, and 60 to 79 years, respectively. Anatomical structures were used as landmarks to standardize the SMAS analysis sites. The SMAS in a fixed analysis area (FAA) was quantified using multi-detector computed tomography (MDCT), and the relationship between SMAS thickness and age, as well as body mass index (BMI), was analyzed. Results In 96 participants (four were excluded due to imaging artifacts), a moderate yet significant negative correlation was found between the average (A)-SMAS thickness within the FAA and age. The A-SMAS thickness in groups M and E was significantly lower than that of group Y, and the mean value of group E was significantly lower than that of group M. SMAS thickness was greater in the young population. The SMAS gradually became thinner with aging. A statistically significant correlation was not found between SMAS thickness and BMI. Conclusions Using MDCT technology, age-related changes in SMAS were successfully analyzed. This highly objective analysis method corroborated the aesthetic surgical knowledge of the SMAS features related to facial aging. In clinical applications, our findings may help elucidate the mechanisms involved in facial aging.

Personalized Research on the Aging Face—A Narrative History

“…A 2020 study fed rats with fewer calories than their ad-libitum counterparts and found that 57% of the age-related genetic changes that occurred in normal rats did not occur in calorie-restricted rats [49]. MRI or CT imaging of SMAS are also evolving to demask its implications into the phenomena of the aging face [50][51][52].…”