Observation of Internal Distribution Behavior of Micro/Nano-Sized Ceramics and Metal Particles in Mice

Abe, Shigeaki; Iwadera, Nobuki; Mutoh, Mami; Koyama, Chika; Akasaka, Tsukasa; Uo, Motohiro; Morita, Manabu; Kuboki, Yoshinori; Haneda, K.; Yawaka, Yasutaka; Uchida, Fumio; Yonezawa, Tetsu; Watari, Fumio

doi:10.4303/bda/d110134

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Due to the protection offered by the mucus layer and the tight junctions between the epithelial cells, the rate of absorption of nanoparticles from the gastrointestinal tract is much lower than their rate of absorption when administered by other routes. 226 Under certain pathological conditions, however, the integrity or function of one or more of the layers of the gastrointestinal tract is compromised and the layers become permeable, causing disorders such as inflammatory bowel disease. The absorption of nanoparticles in the gastrointestinal tract has been studied in rodent and other animal models.…”

Section: Digestive Nanotoxicitymentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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Section: Digestive Nanotoxicitymentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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“…However, the intensity of fluorescence of the Pt elements was at a negligible level. 20) These results suggest that only a small amount of the administered inorganic particles were excreted; in other words, most of the particles were retained in the body even 1 week after being introduced. In fact, some particles were detected in the bone and muscle with low concentration.…”

Section: )mentioning

confidence: 71%

Internal distribution of micro-/nano-sized ceramics and metals particles in mice

Abe

Kida

Iwadera

et al. 2010

J. Ceram. Soc. Japan

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Internal distribution of several nanoparticles in mice has been investigated using scanning X-ray analytical microscopy, magnetic resonance imaging and inductively coupled plasmaatomic emission spectroscopy. According dynamic laser scattering analysis, the actual particle size of obtained metal oxide was similar to that of metal particles. The estimated diameters were ca. one micrometer. After administration through the tail vein of the mice, metal particles quickly reached some organs. The distribution ratio reached a constant value and was then maintained. On the other hand, the metal oxide particles were first localized in the spleen and lung. The concentration in the lung was decreased with post-injection time. This result suggested that the particles were temporally trapped in the lung then removed to other organs. The behaviors between metal and metal oxide were quite different even when those particles had a similar actual particle size. Therefore, the distribution behavior of particles depended on the chemical species.

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“…These results suggested that the administered copper nanoparticles arrived at these organs. In our previous study, metal oxide nanoparticles, such as TiO 2 , CuO and In 2 O 3 , were temporally trapped in the lung then re-transported other organs [12][13][14][15]. On the other hand, metal particles were quickly dispersed to some organs then the relative concentrations remained several weeks at least.…”

Section: Resultsmentioning

confidence: 92%

Internal Diffusion of Biocompatible Polymer-Coated Inorganic Nanoparticles in Mice

Abe

Sakaki

Narushima³

et al. 2011

KEM

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In this study, we succeeded in preparation and characterization of two types of biocompatible polymer-coated inorganic nanoparticles (cupper and silicone oxide). As a biocompatible polymer, gelatin and poly(lactic acid) were used. For determination of their biodistribution, the obtained particles were administered to mice through the tail vein. After administration, the particles in some organs were determined with energy-dispersed X-ray spectrometer. The cupper nanoparticles were observed in the lung and kidney, while the silica particles were in the lung, liver and spleen. The distribution behaviors were quite different from non-polymer coated nanoparticles

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Observation of Internal Distribution Behavior of Micro/Nano-Sized Ceramics and Metal Particles in Mice

Cited by 4 publications

References 12 publications

Perturbation of physiological systems by nanoparticles

Perturbation of physiological systems by nanoparticles

Internal distribution of micro-/nano-sized ceramics and metals particles in mice

Internal Diffusion of Biocompatible Polymer-Coated Inorganic Nanoparticles in Mice

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