Observation of the Serum Uric Acid in Essential Hypertension

Kim, Yeon Ho; Suh, Yeong Do; Son, Sung Pyo; Shim, Yeong Woong; Shin, Yung Woo; Shin, Yeong Kee

doi:10.3904/kjim.1986.1.1.14

Cited by 3 publications

(2 citation statements)

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“…Serum uric acid (UA) levels were demonstrated to be an independent predictor for developing hypertension [ 5 - 7 ]. Regardless of the different ethnic origins, a continuous relationship between serum UA and blood pressure (BP) was observed in African-Americans and whites [ 8 , 9 ] as well as in Asians [ 7 , 10 ] including Koreans [ 11 - 13 ]. For determining the causal role of serum UA in the development of hypertension, Mazzali et al [ 14 ] demonstrated an elevation in serum UA followed by an increase in BP via a crystal-independent mechanism in rat models.…”

Section: Introductionmentioning

confidence: 99%

Relationship between uric acid and blood pressure in different age groups

et al. 2015

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IntroductionSerum uric acid (UA) has been known to have a positive association with blood pressure (BP). However, the relationship between serum UA and BP in different age groups is unclear.MethodsA total of 45,098 Koreans who underwent health examinations at Korea Association of Health Promotion with no history of taking drugs related with UA and/or BP were analyzed for determining the relationship between serum UA and BP.ResultsIn men <40, serum UA was significantly associated with systolic (β = 0.25, p = 0.002) and diastolic BP (β = 0.41, p < 0.001) after adjustment for age, diabetes, dyslipidemia, body mass index, and estimated glomerular filtration rate. Men between ages 40 and 59 showed similar results regarding diastolic BP. The association between serum UA and BP was stronger in women <40 (β = 0.54, p < 0.001 for systolic BP; β = 0.65, p < 0.001 for diastolic BP) and in between 40 and 59 (β = 0.51, p < 0.001 for diastolic BP). The association was not significant in men and women ≥60. The odds ratios (ORs) of hyperuricemia for hypertension were 1.25 (95% confidence interval [CI], 1.08 to 1.45; p = 0.003) and 1.33 (95% CI, 1.11 to 1.60; p = 0.002) in men <40 and in between 40 and 59, respectively, in the multivariate analysis. The OR was 2.60 (95% CI, 1.37 to 4.94; p = 0.0034) in women <40. The relationship between hyperuricemia and hypertension was not significant in other age/gender groups.DiscussionIn contrast to the elderly of 60 and over, the non-elderly showed significant associations between serum UA and BP.

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Section: Introductionmentioning

confidence: 99%

Relationship between uric acid and blood pressure in different age groups

et al. 2015

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“…[5][6][7] Irrespective of the different ethnic origins & regions, a certain association between serum UA and blood pressure (BP) has been seen in African-Americans and whites 8,9 as well as in the Asians 7,10 including Koreans. [11][12][13] In the study of causal role of serum UA in the development of hypertension, Mazzali et al 14 observed an elevation in the levels of serum UA followed by an increase in BP via a crystal-independent mechanism in rat models. Further it has also been found that reduction of serum UA was associated with a decrease in BP through the regulation of renin-angiotensin and nitric oxide system.…”

Section: Introductionmentioning

confidence: 99%

A study on association of serum uric acid and blood pressure in hypertensives at a tertiary care centre

Babu¹,

Samozai

Devarapalli³

2022

IJCAP

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Hypertension(HTN) is the most common and significant cardiovascular disease because of its prevalence and severity of the damage to the mankind globally. Hyperuricemia, a condition of increased levels of Serum Uric acid (UA) has been proposed to have an association with hypertension in various studies. In certain studies, serum uric acid levels has been found to be an independent predictor for developing hypertension. On the basis of the above observations, we have proposed to the present study to compare the relationship between serum UA and hypertension in a single cohort with adjustment of all possible confounding factors.A total of 245 subjects were enrolled in this study during a regular routine health checkup. All subjects were informed about the study aims Individuals having a known history of gout and cardiac or severe renal diseases and patients who are already under medication for anti-hyperuricemic were excluded from the study. General information like Name, Age, Sex, Occupation, Address along with history of any drug intake and anthropometric indices - body weight (BW), body height (BH), hip circumference (HC), waist circumference (WC), and lifestyle information have been obtained. The data has been arranged in tables with mean ± SD for further analysis. The data is analyzed using IBM SPSS version 23. The difference between the groups for baseline variables was done by independent sample t-test (two-tailed). Pearson’s correlation coefficient test was performed to assess the interrelationships between baseline variables and SUA concentrations. The differences for the variables among the groups was determined by using One-way ANOVA.Of the 245 subjects, mean age of the participants was 42.4 ± 8.4 years (range 18–70 years). There was no significant difference in the mean levels of Height, Weight and BMI between the two groups. Mean levels of WC, HC were significantly different between two group (p < 0.05) subjects. The mean levels of SBP and DBP were also significantly more in the hypertensive subjects (p < 0.001). In Pearson’s correlation coefficient test, SUA levels were significantly related with SBP and DBP. In this study, we have observed comparatively a stronger relationship for SUA concentration with hypertension and prehypertension in the participants. The extended mechanism for the effect of SUA on hypertension is yet to be elucidated. There are some hypotheses partly explain the association between SUA and high blood pressure. One of the possible mechanism might be uric acid deposition on the blood vessels walls activates the renin-angiotensin system, suppress the liberate of carbon monoxide, enhance inflammation, and leads to vasoconstriction on later stage, which consequently leads to hyperplasia and incidence of hypertension. Another possibility involving oxidative stress and endothelial dysfunction associated with high SUA levels may contribute to high blood pressure.

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The Relationship of the Hypertension, Insulin Resistance, and Metabolic Syndrome in the Serum Uric Acid Level

et al. 2004

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Background and Objectives：The relationship between serum uric acid and metabolic syndrome variables has not been reported in Korea. Therefore, whether the circulating levels of serum uric acid are independently related to hypertension, insulin resistance and the variables of metabolic syndrome were assessed. Subjects and Methods：A total of 53,477 health screen examinees were enrolled and divided into four groups (Quartile 1：<4.2 mg/dL, Quartile 2：4.2-5.29 mg/dL, Quartile 3：5.3-6.29 mg/dL, Quartile 4：>6.29 mg/dL) according to their serum uric acid level. The blood pressure, lipid profiles, fasting plasma glucose, waist circumference, HOMA, high sensitivity CRP and apolipoprotein were compared between the four groups. Results：There was a positive association between blood pressure and the serum uric acid level (p<0.001). After adjustment for covariates the prevalence of hypertension due to uric acid was 1.192 (95% CI, 1.038-1.368 p=0.013), and 1.408 (95% CI, 1.221-1.623 p<0.001) times higher in subjects in the third and fourth uric acid level quartiles, respectively, compared to the subjects in the first quartile. Insulin resistance and metabolic syndrome variables were positively correlated with the serum uric acid level. The number of metabolic syndrome variables was also increased with an elevated serum uric acid level. Conclusion：Our study suggests that serum uric acid levels were independently associated with hypertension, insulin resistance and the variables of metabolic syndrome in the Korean population. Although the serum uric acid level was normal value, the risk of metabolic syndrome was increased with an elevated serum uric acid level. However, because of the cross-sectional nature of our study, these findings should be confirmed in prospective cohort studies. (Korean Circulation J 2004;34(9):874-882)

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Observation of the Serum Uric Acid in Essential Hypertension

Cited by 3 publications

References 26 publications

Relationship between uric acid and blood pressure in different age groups

Relationship between uric acid and blood pressure in different age groups

A study on association of serum uric acid and blood pressure in hypertensives at a tertiary care centre

The Relationship of the Hypertension, Insulin Resistance, and Metabolic Syndrome in the Serum Uric Acid Level

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