Observational pilot study of reported symptoms of obstructive sleep apnoea in children with epilepsy

Urquhart, Don S.; Kehinde, Olaniyi O; McLellan, Ailsa

doi:10.1111/dmcn.13173

Cited by 13 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Ethiopia, 19% of college students were found to have high risk for clinical OSA (11). A study in Egypt found a prevalence of 42% among children with epilepsy, with an observation that OSA contributed to seizure frequency (6). Nigerian adult hypertensives were found to have a 52% prevalence of clinical sleep apnea while patients with type II diabetes mellitus had a 27% prevalence in the same population (7,8).…”

Section: Discussionmentioning

confidence: 99%

A Look into Obstructive Sleep Apnea among Ethiopians

Mekonnen¹,

Gasiorek²,

Key³

et al. 2019

Ethiop J Health Sci

View full text Add to dashboard Cite

BackgroundObstructive Sleep Apnea (OSA) is prevalent throughout the world. However, there are currently limited data concerning the prevalence of OSA in populations that originate from developing countries; the prevalence of OSA is expected to rise in these countries. OSA is poorly characterized amongst Ethiopians, and our study is the first to describe clinical characteristics of OSA among Ethiopians.MethodsWe conducted a retrospective study of primarily Ethiopian patients at an internal medicine clinic in Rockville, Maryland. All patients (n=24) were evaluated for daytime sleepiness using the Epworth Sleepiness Scale (ESS) and received physical examinations and polysomnograms (PSG) by either portable monitoring (Itamar WatchPAT 200 device) or in-lab. Statistical analyses were performed in R.ResultsLinear regression model of Body-Mass Index (BMI) and Apnea-Hypopnea Index (AHI) indicated that for every 1-unit increase in BMI, there was a 0.8657-unit increase in AHI (p<0.05). Pearson's correlation coefficient indicateda positive linear relationship between BMI and AHI (0.47) (p<0.05). Adjusted linear regression model for AHI and oxygen saturation indicated that for every 1-unit increase of AHI, there was a 0.8452-unit decrease in nocturnal oxygen saturation (p<0.05). Pearson's correlation coefficient did not demonstrate significance between AHI and oxygen desaturation (p=0.062). Patients received either continuous positive airway pressure (CPAP) (n=15) or oral appliance therapy (n=3).ConclusionAll patients who complied with therapy reported improved sleep quality, snoring resolution, and improved daytime alertness. Practitioners in developing countries should suspect OSA in the right clinical setting and offer diagnostic and therapeutic services when available.

show abstract

Section: Discussionmentioning

confidence: 99%

A Look into Obstructive Sleep Apnea among Ethiopians

Mekonnen¹,

Gasiorek²,

Key³

et al. 2019

Ethiop J Health Sci

View full text Add to dashboard Cite

show abstract

“…The prevalence of OSA is significantly higher in the epilepsy group-35% versus healthy children-7.4%. In refractory epilepsy, 44% children have the diagnosis of OSA, in other form of epilepsy around 31% [32,33]. It is especially important for clinicians, who frequently under-recognize and misinterpret sleep disorders in epilepsy patients.…”

Section: Sleep and Epilepsymentioning

confidence: 99%

Melatonin in Childhood Epilepsy and in Child Neurology

Paprocka¹,

Kijonka²,

Sokół³

2018

Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches

View full text Add to dashboard Cite

Melatonin (MLT) was isolated as a hormone by Lerner in 1958, and since then, intense studies have been under way with respect to its action and possibilities of application in various fields of medicine. Despite the existence of multiple antiepileptic medications and progress that has taken place in neurosurgical treatment of epilepsy, drug-resistant epilepsy continues to be a phenomenon that occurs in 30-35% children treated for epileptic seizures. Reports presented in the study have shown that children with epilepsy suffer from sleep disorders. Sleep deprivation may cause seizures, and on the other hand, an increased frequency of seizures may lead to sleep disturbances.

show abstract

“…Major risk factors for sleep apneas in childhood epilepsy include poor seizure control and on multiple antiepileptic medications [18]. Urquhart et al [19] studied obstructive sleep apnea symptoms among 33 children with epilepsy (21 males, 12 females), along with 42 controls (20 males, 22 females). They found that 55% children with epilepsy scored 0.33 or higher on the sleep-related breathing disorder questionnaire compared with 7% in the comparison group (p<0.001).…”

Section: Obstructive Sleep Apnea (Osa)mentioning

confidence: 99%

Sleep Disorders in Childhood Epileptic Disorders

Zhao¹,

Avula²,

Tolaymat³

2017

SM J Sleep Disord

View full text Add to dashboard Cite

Sleep disorders are common in children, especially in children with epileptic disorders. This article reviewed most recent publications supporting a reciprocal relationship between sleep disorders and childhood epileptic disorders as well as the underlying mechanisms involved in both disease processes, i.e. similar neuronal networks in the genesis of sleep and epileptic seizures. Evidence support that sleep disorders can aggravate Interictal Epileptiform Discharges (IEDs) and nocturnal seizures in children with epilepsy, leading to poor seizure control and increasing functional disturbance in patients with childhood epileptic disorders; On the other hand, childhood epileptic disorders and some antiepileptic medications and vagus nerve stimulator can change sleep quality and architecture of sleep, resulting in an increase in troubled sleep, which can lead to increased sleep disorders. Recognizing and effectively treating sleep disorders in patients with childhood epileptic disorders can improve seizure control and overall functioning and vice versa.

show abstract

Observational pilot study of reported symptoms of obstructive sleep apnoea in children with epilepsy

Cited by 13 publications

References 38 publications

A Look into Obstructive Sleep Apnea among Ethiopians

A Look into Obstructive Sleep Apnea among Ethiopians

Melatonin in Childhood Epilepsy and in Child Neurology

Sleep Disorders in Childhood Epileptic Disorders

Contact Info

Product

Resources

About