Observations on the cytology of the secretions in allergy of the nose and paranasal sinuses

Hansel, French K.

doi:10.1016/s0021-8707(34)90159-3

Cited by 54 publications

(15 citation statements)

References 12 publications

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“…In this method, secretions in the nasal airways are blown onto wax paper or a plastic wrap and then placed onto a glass slide. 80 The cells are only those contained in the secretions and may thus reflect a different population from those collected from the epithelium. Another disadvantage of this technique is that many children and patients with some nasal disorders cannot produce an adequate secretion specimen.…”

Section: Methods Of Measurementmentioning

confidence: 99%

Objective monitoring of nasal airway inflammation in rhinitis

Howarth

Persson²,

Meltzer

et al. 2005

Journal of Allergy and Clinical Immunology

127

151

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Section: Methods Of Measurementmentioning

confidence: 99%

Objective monitoring of nasal airway inflammation in rhinitis

Howarth

Persson²,

Meltzer

et al. 2005

Journal of Allergy and Clinical Immunology

127

151

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“…Eyermann, in 1927, detected the presence of granulocyte eosinophils in the nasal secretions of allergic patients and showed their importance in diagnosing the disease [12]. Thanks to this discovery, a great value was attributed to the identification of specific cellular subsets related to different nasal pathologies [13-15], and this consideration opened the way to the routine use of nasal cytology in the study of allergic and non allergic, infectious and inflammatory rhinitis. Different factors have been responsible for the increased interest for this diagnostic tool and its widespread use: on one hand, the fact that the technique is easy to perform, and, on the other hand, that it is a non-invasive approach.…”

Section: Reviewmentioning

confidence: 99%

Nasal cytology in children: recent advances

Gelardi

Marseglia

Landi³

et al. 2012

Ital J Pediatr

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Nasal cytology is a very useful diagnostic tool in nasal disorders, being able to detect both the cellular modifications of the nasal epithelium caused by either allergen exposure or irritative stimuli (that may be physical or chemical, acute or chronic), or inflammation. Over these past few years, nasal cytology has allowed to identify new disorders, such as the non-allergic rhinitis with eosinophils (NARES), the non-allergic rhinitis with mast cells (NARMA), the non-allergic rhinitis with neutrophils (NARNE), and the non-allergic rhinitis with eosinophils and mast cells (NARESMA). The rhinocytogram is actually able to distinguish the different forms of allergic rhinitis and to suggest the appropriate treatment, such as antinflammatory drugs or allergen immunotherapy. The technique is easy to perform and nasal cytology is therefore particularly suitable even for children. Such a consideration suggests the utility of a systematic use of nasal cytology in the diagnostic work-up of nasal disorders in children, in order to reach a proper defined diagnosis and to set a rational therapeutic approach: in facts, these two elements are fundamental in order to prevent from complications and to improve the patient’s quality of life.

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“…Cytologic techniques have been developed over the years to document the dynamic cellular changes that may take place in each of the compartments when the nose is exposed to allergens, infectious organisms or irritants. 296,298,[309][310][311] After collection, the sampled specimen is typically placed on a microscope slide, fixed, and then stained, and, for example, the number of inflammatory cells is counted in each of ten high power fields. The mean number of neutrophils, eosinophils and basophilic cells per ten high power fields are typically established and reported.…”

Section: Common Measures Of Nasal Cytologymentioning

confidence: 99%