Obsessive-Compulsive Disorder in Adolescent Schizophrenia Patients

Nechmad, Allon; Ratzoni, Gideon; Poyurovsky, Michael; Meged, Sorin; Avidan, Gideon; Fuchs, Camil; Bloch, Yuval; Weizman, Ronit

doi:10.1176/appi.ajp.160.5.1002

Cited by 104 publications

(64 citation statements)

References 15 publications

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“…This finding contradicts other studies that report a worse outcome and higher levels of positive and negative symptoms in patients with comorbid schizophrenia and OCD (5)(6)(7)(8). Recently, it was found that adolescent schizophrenia patients with OCD had higher affective flattening or blunting scores than those without OCD (9). Most of these studies are limited by cross-sectional design, inclusion of patients in different stages of their illness, and the inability to control for confounders such as the effects of chronicity or long-standing treatment effects.…”

contrasting

confidence: 56%

Obsessive-Compulsive Symptoms and Positive, Negative, and Depressive Symptoms in Patients with Recent-Onset Schizophrenic Disorders

Haan

Hoogenboom²,

Beuk

et al. 2005

Can J Psychiatry

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Obsessive-compulsive symptoms and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders de Haan, L.; Hoogenboom, B.; Beuk, N.; van Amelsvoort, T.; Linszen, D.H. Published in:Canadian Journal of Psychiatry Link to publication Citation for published version (APA):de Haan, L., Hoogenboom, B., Beuk, N., van Amelsvoort, T., & Linszen, D. H. (2005). Obsessive-compulsive symptoms and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders. Canadian Journal of Psychiatry, 50(9), 519-524. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Objectives: To study the relation between obsessive-compulsive symptoms (OCS) and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders. Methods:We undertook a prospective study of 113 consecutively hospitalized patients with recent-onset schizophrenia or related disorders diagnosed according to DSM-IV criteria. We compared 3 subgroups: one without comorbid OCS, one with OCS not fulfilling DSM-IV criteria for obsessive-compulsive disorder (OCD), and one with comorbid OCD diagnosed according to DSM-IV criteria. We assessed OCS severity at admission and 6 weeks thereafter with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The Positive and Negative Syndrome Scale (PANSS) and the Montgomery-Asberg Depression Rating Scale (MADRS) were independently administered. Results:At admission, patients with schizophrenic disorders and OCD had higher mean MADRS scores than both other groups; patients with OCS not fulfilling DSM-IV criteria for OCD had lower mean PANSS negative subscale scores than both other groups. After 6 weeks, there were no significant between-group differences, and OCS severity remained constant. Conclusions:Acute patients with recent-onset schizophrenia and OCD have more severe depressive symptoms but do differ in negative symptoms, compared with patients without comorbid OCD. Mild OCS may be related to less severe negative symptoms. During regular inpatient treatment, OCS severity remains constant.(Can J Psychiatry 2005;50:519-524)Information on funding and support and author affiliations appears at the end of the article.Clinical Implications · Acute patients with recent-onset schizophrenia and OCD...

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contrasting

confidence: 56%

Obsessive-Compulsive Symptoms and Positive, Negative, and Depressive Symptoms in Patients with Recent-Onset Schizophrenic Disorders

Haan

Hoogenboom²,

Beuk

et al. 2005

Can J Psychiatry

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“…Four patients exhibited obsessive compulsive symptoms, which has been reported in both TS and in schizophrenia [39,40]. The presence of learning disabilities in individuals with TS and/or ADHD is also not surprising, nor is it so with schizophrenia, especially in light of recent research into the neurocognitive impairments present in that disorder [41,42].…”

Section: Discussionmentioning

confidence: 89%

Tourette syndrome and comorbid early-onset schizophrenia

Kerbeshian¹,

Peng²,

Burd³

2009

Journal of Psychosomatic Research

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“…Our finding showed that 39.3% of the subjects with OCD, 6.5% of the subjects with subthreshold OCD, and 7.3% of the subjects with OCS met diagnostic criteria of possible psychotic disorder. The frequent co-occurrence of OCD and psychotic disorders are well documented in epidemiological and clinical studies [4,9,16,17,27,39,41,45,46,55]; and possible pathophysiological overlapping between OCD and psychotic disorders has been suggested [24,56]. Nevertheless, in a study by de Haan and colleagues [12] psychotic disorders were present in only 1.7% of patients with OCD, and De Haan and colleagues [13] suggested that treatment of psychosis induces OCS or OCD in some patients with a primary diagnosis of psychosis.…”

Section: Discussionmentioning

confidence: 99%

Obsessive–compulsive disorder in the community: 12-month prevalence, comorbidity and impairment

Adam

Meinlschmidt

Gloster³

et al. 2011

Soc Psychiatry Psychiatr Epidemiol

158

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Background Although subthreshold conditions are associated with impairment in numerous disorders, research on obsessive-compulsive disorder (OCD) below the diagnostic threshold of DSM-IV in the general population is limited. Purpose To estimate the DSM-IV 12-month prevalence, comorbidity and impairment of OCD, subthreshold OCD (i.e., fulfilling some but not all core DSM-IV criteria), and obsessive-compulsive symptoms (OCS) (i.e., endorsement of OCS without fulfilling any core DSM-IV criteria) in a general population sample. Methods Data from the German National Health Interview and Examination Survey-Mental Health Supplement (N = 4181, age 18-65 years), based on the standardized diagnostic Munich Composite International Diagnostic Interview. Results The 12-month prevalence of OCD was 0.7%, subthreshold OCD was 4.5%, and OCS was 8.3%. Subjects in all three groups showed higher comorbidity (odds ratios [ORs] C 3.3), compared to those without OCS. The OCD, subthreshold OCD and OCS were all associated with increased odds of substance abuse/dependence-, mood-, anxiety-and somatoform disorders, with especially strong associations with possible psychotic disorder (ORs C 4.1) and bipolar disorders (ORs C 4.7). Participants in all three groups showed higher impairment (ORs C 3.1) and healthcare utilization (ORs C 2.4), compared to those without OCS, even after controlling for covariates. Conclusions Individuals with subthreshold OCD and OCS, not currently captured by DSM-IV OCD criteria, nevertheless show substantial comorbidity, impairment and health-care utilization. This should be taken into account in future conceptualization and classification of OCD and clinical care.

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Obsessive-Compulsive Disorder in Adolescent Schizophrenia Patients

Abstract: A substantial proportion of adolescent schizophrenia inpatients have concomitant OCD. A prospective study is needed to evaluate the clinical course, response to treatment, and prognosis for this complex disorder.

Cited by 104 publications

References 15 publications

Obsessive-Compulsive Symptoms and Positive, Negative, and Depressive Symptoms in Patients with Recent-Onset Schizophrenic Disorders

Obsessive-Compulsive Symptoms and Positive, Negative, and Depressive Symptoms in Patients with Recent-Onset Schizophrenic Disorders

Tourette syndrome and comorbid early-onset schizophrenia

Obsessive–compulsive disorder in the community: 12-month prevalence, comorbidity and impairment

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