Obsessive–compulsive disorder subgroups: a symptom-based clustering approach

Calamari, John E.; Wiegartz, Pamela S.; Janeck, Amy S.

doi:10.1016/s0005-7967(98)00135-1

Cited by 157 publications

(92 citation statements)

References 26 publications

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“…While McKay et al (2006) was likely underpowered (n = 137), Stewart et al (2007) (n = 231) still derived somewhat different factors than previous adult category-level analyses, including a factor in which contamination/cleaning loaded with the aggressive and somatic categories. Despite similarities to adult cluster analyses of OCD symptoms (Calamari et al, 1999(Calamari et al, , 2004, Ivarsson and Valderhaug (2006) (n = 213) noted important differences in their child/adolescent cluster analysis such as the absence of subgroups for hoarding and symmetry/ordering. The authors speculated that these discrepancies might be due to developmental differences in OCD phenomenology and clinical course in children/adolescents as compared with adults (Jaisoorya et al, 2003;Stewart et al, 2004).…”

Section: Subjectsmentioning

confidence: 90%

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Pinto

Greenberg

Grados

et al. 2008

Psychiatry Research

144

115

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Despite progress in identifying homogeneous subphenotypes of obsessive compulsive disorder (OCD) through factor analysis of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been only limited attempts to evaluate the © 2007 Elsevier Ireland Ltd. All rights reserved. *Corresponding author: Anthony Pinto, Ph.D., Butler Hospital, 345 Blackstone Blvd., Providence, RI 02906 USA; tel: 1-401-455-6299; fax: 1-401-455-6442; e-mail: Anthony_Pinto@brown.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item-and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for 4 of the 5 factors, Hoarding and Taboo Thoughts were the most robustly familial (r ICC ≥ 0.2). This report presents considerable converging evidence for a 5-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance.The results support investigation of this multidimensional model in OCD genetic linkage studies.

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Section: Subjectsmentioning

confidence: 90%

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Pinto

Greenberg

Grados

et al. 2008

Psychiatry Research

144

115

View full text Add to dashboard Cite

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“…However, many patients have ordering and/or symmetry compulsions, as well as repetition compulsions, harbouring a wish for a ''just right'' feeling (Livingston-Van Noppen, Rasmussen, . This type of compulsion is in many ways different from classical OCD, even to the extent that it can be thought of as a particular OCD-factor, i.e., ''Symmetry and Ordering'' (Baer, 1994;Leckman, Grice, Boardman, & Zhang, 1997) or as a subgroup of patients with such symptoms (Calamari, Wiegartz, & Janeck, 1999;Ivarsson & Valderhaug, 2006).…”

Section: Ocd Nosology Debatementioning

confidence: 99%

Quality of life in children with OCD before and after treatment

Weidle

Ivarsson

Thomsen

et al. 2014

Eur Child Adolesc Psychiatry

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Barn og ungdom med tvangslidelse (OCD): Komorbiditet og livskvalitet.OCD er kjennetegnet av ubehagelige tvangstanker og tidskrevende tvangshandlinger og forekommer hos 0,5 -3 % av barnebefolkningen. Ubehandlet får lidelsen et kronisk forløp hos 40 -75 %. Hovedmålsettingen for avhandlingen var å belyse to viktige aspekter av OCD: Samtidig forkommende andre tilstander (komorbiditet) og livskvalitet. Komorbiditet i form av autistiske trekk ble undersøkt hos barn og unge med OCD og sammenliknet med en kontrollgruppe fra den generelle befolkningen. Utvalget er hentet fra en svensk OCD klinikk (Göteborg), kontrollgruppen ble rekruttert i en middels stor by fra samme geografiske området. Autistiske symptomer forekom hos omtrent en femtedel av barn og unge med OCD og var dermed mye hyppigere enn i den generelle befolkningen. Allikevel hadde flertallet ikke slike symptomer som tyder på at kombinasjonen av autistiske symptomer og OCD forekommer i en undergruppe, men er ikke et generelt trekk ved OCD. l den internasjonalt pågående debatten om det er empirisk grunnlag for å betrakte tilstander som OCD, Tourettes syndrom, spiseforstyrrelser og autismespekterforstyrrelser som deler av et såkalt Obsessive-Compulsive Spectrum (OCSD) støtter våre resultater ikke klassifikasjon av autismespekterforstyrrelser som del av dette spektrum. At en undergruppe av barn med OCD har autistiske trekk må dog tas i betraktning når man skal skreddersy individuell tilpasset behandling for barn med OCD.Å utforske livskvalitet hos barn og unge med OCD er relevant, fordi det finnes et stort antall studier av livskvalitet hos voksne med OCD, men veldig få undersøkelser hos barn. Livskvalitet ble undersøkt hos barn og unge med OCD som deltok i NordLOTS studien (Nordic Longterm OCD treatment study) og sammenliknet med livskvalitet av skoleelever i Sør-Trøndelag. NordLOTS-studien er en nordisk multisenterstudie hvor enheter som behandler OCD hos barn og ungdom har anvendt samme prosedyre for utredning, behandling og evaluering. Studien har inkludert 135 barn og ungdom i alder 7-17 år med OCD. Pasientene ble behandlet med kognitiv atferdsterapi (KAT) med eksponering i en "standartdose" på 14 timer og ble deretter evaluert. Livskvalitet og sosial kompetanse var betydelig redusert hos barn og ungdom med OCD sammenlignet med den generelle befolkningen. Hos barn med komorbide lidelser beskrev foreldrene lavere livskvalitet enn hos de med bare OCD. Etter behandlingen rapporterte de som hadde effekt av behandlingen en livskvalitet i samme nivå som i den generelle befolkningen, mens de som ikke hadde effekt beskrev ingen forbedring av livskvaliteten. Basert på våre funn anbefales å anvende livskvalitets evaluering i klinikk og forskning for å få med et mål for barns og foreldrenes subjektive opplevelse i vurderingen og dermed en mer helhetlig forståelse av OCD hos barn og unge. Ovennevnte avhandling er funnet verdig til å forsvares offentlig for graden philosophiae doctor (ph.d.). Disputas finner sted i Auditoriet, Medisinsk Teknisk Forskningssenter, fredag 9...

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“…One reason is the remarkably heterogeneous features found in OCD patients (McKay et al, 2004). For one, the OCD phenomenology itself shows many diverse features (Calamari et al, 1999;Ivarsson & Valderhaug, 2006;Leckman et al, 1997). Following this lead, a term, OC spectrum disorders has been coined as an "umbrella concept" to express similarities that are found between OCD and various disorder, for example hypochondriasis, body dysmorphic disorder, trichotillomania, but also tic disorders and autism (see (Bartz & Hollander, 2006) for a recent review of this issue).…”

Section: Ocd Nosology Debatementioning

confidence: 99%

“…Many OCD patients are characterized by repetitive behaviors just like ASD-patients are. In OCD, many patients have ordering and symmetry compulsions, as well as repetition compulsions harboring a wish for a "just right" feeling (Rasmussen & Eisen, 1990;Rapoport, 1989), even to the extent that this can be thought of as a particular OCD-factor, i.e., "Symmetry and Ordering" (Baer, 1994;Leckman et al, 1997) or a group of patients with such symptoms (Calamari et al, 1999;Ivarsson & Valderhaug, 2006). Likewise some patients with strong traits of hoarding (Baer, 1994;Leckman et al, 1997) seem to be attached to objects in a way that is akin to that seen in ASD.…”

mentioning

confidence: 99%

Autism spectrum traits in children and adolescents with obsessive-compulsive disorder (OCD)

Ivarsson

Melin

2008

Journal of Anxiety Disorders

118

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Objective: Assess the prevalence of autistic traits (AST) in pediatric OCD and relate them to OCD co-morbidity and compare them with published normative data.Methods: Pediatric patients with Obsessive-Compulsive Disorder (n=109) according to the DSM IV were studied using parent ratings of the Autistic Symptom/Syndrome Questionnaire to assess AST symptoms as a continuous rather than categorical trait. The KSADS, a semistructured psychiatric interview, was used for the psychiatric diagnostic evaluation. Also, the Children's Yale-Brown Obsessive Compulsive Scale was used to assess OCD severity and other clinical features.Results: AST was common among our patients. Symptom scores were highest in cases with co-morbid Autistic Spectrum Disorders, but cases with other co-morbidities as tics/Tourette and attention/behavioral disorders also scored higher. All sub-groups, including OCD without these co-morbidities scored higher than the Swedish normative group. Using ANOVA, comorbid ASD and tics/Tourette (plus a term for gender by tic interaction indicating that girls with tics scored high, otherwise low) and pathological doubt contributed (R 2 = .41) to the AST-traits, while OCD severity and co-morbid anxiety-and depressive disorders did not.Conclusion: AST traits are prevalent in OCD and seem to be intricately associated with the co-morbidities as well as the OCD syndrome itself. The findings might have implication for our nosological understanding of OCD which currently is discussed.4

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Obsessive–compulsive disorder subgroups: a symptom-based clustering approach

Cited by 157 publications

References 26 publications

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

Quality of life in children with OCD before and after treatment

Autism spectrum traits in children and adolescents with obsessive-compulsive disorder (OCD)

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