“…These goals are can be best accomplished with neuraxial anesthesia [12][13][14][15], although some have used general anesthesia successfully [12,16]. Recent modeling suggests that PVR is the major determinant of preload and, thus, cardiac output in Fontan physiology [17]; and given that PVR progressively increases over time when presented with nonpulsatile flow [11], it is likely that phosphodiesterase inhibitors or inhaled nitric oxide may be needed.…”