The main objective of this study was to evaluate the use of additives in producing foamed concrete blocks, which were made by totally replacing natural sand with civil construction waste (CCW). The concrete blocks were developed in accordance with an experimental design that used the complete factorial statistical method, for which three factors with different levels were considered: cement type (CP-V, CP II-Z, and CP II-F); use of additive (without additive, plasticizer, air entrainment, and superplasticizer) and foam amount (5.7%, 7.7%, and 9.5% of the total mass). The influence of each factor and the interactions between them were assessed on the following response variables: compressive strength, dry and saturated density, air voids, water absorption, and thermal conductivity. The results show that all factors had a significant influence on the variable response. For example, the use of the superplasticizer additive resulted in higher compressive strength, lower density, lower air void, and lower thermal conductivity. Finally, the use of additives had little influence on the response variables in relation to the other factors.