Occupational contact urticaria from penicillin

Rudzki, E; Rebandel, P

doi:10.1111/j.1600-0536.1985.tb02539.x

Cited by 48 publications

(12 citation statements)

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“…Drugs are one of the most common causes of allergic diseases in HCW, including nurses and pharmacists, who both work with drugs 3-9. HCW in hospitals are commonly exposed to beta-lactam antibiotics, such as penicillins and cephalosporins.…”

Section: Introductionmentioning

confidence: 99%

IgE Sensitization to Cephalosporins in Health Care Workers

Kim

Jin

et al. 2012

Allergy Asthma Immunol Res

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PurposeCephalosporins can induce occupational allergies, such as asthma, urticaria, and anaphylaxis. We investigated the prevalence and risk factors of sensitization to cephalosporin.MethodsA total of 161 health care workers (HCW), including 138 nurses and 23 pharmacists, and 86 unexposed non-atopic healthy controls were recruited from a single tertiary hospital and the general population. A questionnaire regarding work-related symptoms was administered along with skin prick tests (SPT) to the three most commonly used cephalosporins (cefotiam, ceftriaxone, and ceftizoxime). Serum specific IgE antibodies to conjugates of the three cephalosporins and human serum albumin (HSA) were measured by enzyme-linked immunosorbent assay (ELISA). Binding specificities were confirmed by ELISA inhibition tests.ResultsThe prevalence of work-related symptoms in association with cephalosporins was 17.4%. The sensitization rate to any cephalosporin was 3.1% by SPT. Sensitization rates determined by measurement of serum specific IgE antibodies were 17.4% for any cephalosporin, 10.4% for cefotiam, 6.8% for ceftriaxone, and 3.7% for ceftizoxime. A personal history of any antibiotic allergy was a risk factor for work-related symptoms (OR, 24.93; 95% CI, 2.61-238), but not for the presence of serum specific IgE antibodies to cephalosporins (OR, 0.9; 95% CI, 0.18-4.53). A personal history of atopic dermatitis was a risk factor for the presence of serum specific IgE antibodies to cefotiam-HSA conjugate (OR, 6.30; 95% CI, 1.23-32.3).ConclusionsA high cephalosporin sensitization rate (17.4%) was detected by ELISA in HCW exposed to cephalosporins. Monitoring of serum specific IgEs to cephalosporin-HSA conjugates will be useful for detecting sensitized subjects.

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Section: Introductionmentioning

confidence: 99%

IgE Sensitization to Cephalosporins in Health Care Workers

Kim

Jin

et al. 2012

Allergy Asthma Immunol Res

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“…Occupational contact urticaria from penicillin was described in 1985 (3, 4). Further cases were later reported, but none from amoxicillin.…”

Section: Discussionmentioning

confidence: 99%

Occupational allergic contact urticaria from amoxicillin

et al. 2001

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“…The earliest report relates to nonoccupational cephaloridine anaphylaxis in a nurse with no history of past personal exposure . Three cases of OcAn to penicillin were reported by Rudzki and Rebandel ; all cases were nurses who had their reaction while preparing medication at work. Tadokoro et al.…”

Section: Specific Causes Of Occupational Anaphylaxismentioning

confidence: 99%

Occupational anaphylaxis - an EAACI task force consensus statement

Siracusa

Folletti

Wijk

et al. 2015

Allergy

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Anaphylaxis is a systemic allergic reaction, potentially life-threatening that can be due to nonoccupational or, less commonly, to occupational triggers. Occupational anaphylaxis (OcAn) could be defined as anaphylaxis arising out of triggers and conditions attributable to a particular work environment. Hymenoptera stings and natural rubber latex are the commonest triggers of OcAn. Other triggers include food, medications, insect/mammal/snake bites, and chemicals. The underlying mechanisms of anaphylactic reactions due to occupational exposure are usually IgE-mediated and less frequently non-IgE-mediated allergy or nonallergic. Some aspects of work-related allergen exposure, such as route and frequency of exposure, type of allergens, and cofactors may explain the variability of symptoms in contrast to the nonoccupational setting. When assessing OcAn, both confirmation of the diagnosis of anaphylactic reaction and identification of the trigger are required. Prevention of further episodes is important and is based on removal from further exposure. Workers with a history of OcAn should immediately be provided with a written emergency management plan and an adrenaline auto-injector and educated to its use. Immunotherapy is recommended only for OcAn due to Hymenoptera stings.

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Occupational contact urticaria from penicillin

Cited by 48 publications

References 0 publications

IgE Sensitization to Cephalosporins in Health Care Workers

IgE Sensitization to Cephalosporins in Health Care Workers

Occupational allergic contact urticaria from amoxicillin

Occupational anaphylaxis - an EAACI task force consensus statement

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