Occurrence of Additional Primary Neoplasms in Patients with Laryngeal Carcinoma in Israel (1960–1976)

Deviri, E; Eliachar, Isaac; Bartal, Arie H.; Steinitz, R.; Goldsher, Moshe; Robinson, Eliezer

doi:10.1177/000348948209100306

Cited by 32 publications

(18 citation statements)

References 26 publications

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“…'~ The postoperative complications rate in this study compared favorably with those of The large number of patients in this study who both drank alcohol and smoked may have contributed to the high incidence of multiple primary cancer development (1 1% in Group 1),38 which is more than double the 5% reported by Deveri in 1982. 39 The alarmingly low survival rate of black patients in this study (Tables 3 and 4) can be attributed to various causes. First, about half of these patients (48%) presented late for treatment, at Stages 111 and IV, which makes therapeutic cure very unlikely.…”

Section: Wusje and Newmunmentioning

confidence: 71%

Laryngeal carcinoma in black patients

Wasfie

Newman

1988

Cancer

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The majority of reports on laryngeal carcinoma are from institutions serving a mostly white population. This report is about laryngeal carcinoma in black patients at Harlem Hospital Center. In a retrospective analysis, 113 patients (male-female, 3.5:1) with carcinoma of the larynx were examined. Sixty-seven patients (59%) were between 50 and 60 years of age. There were two patients (2%) with carcinoma in situ, 15 (13%) in Stage I, 40 (35%) in Stage II, 39 (35%) in Stage III, and 15 (13%) in Stage IV. Of the 113 patients, 70 (62%) were treated surgically, Group I; 24 (21%) received radiotherapy only, Group 2; and 19 (17%) refused treatment or died before therapy initiation. For patients in Group 1, the 1-year survival rate was 68% (43 of 63), the 3-year survival rate was 38% (20 of 53), and the 5-year survival rate was 15% (7 of 47). For Group 2, the survival rate was 48% (11 of 23), 30% (7 of 23), and 14% (3 of 22), respectively. In this patient population, laryngeal carcinoma occurred at a younger age than other reported groups, had a higher incidence in females, and had a lower 1-, 3-, and 5-year survival rate.

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Section: Wusje and Newmunmentioning

confidence: 71%

Laryngeal carcinoma in black patients

Wasfie

Newman

1988

Cancer

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“…Consistent with this overall theory, recent investigations examining the molecular basis of SPTs claim that at least a proportion of these originate from a single contiguous pre-malignant epithelial field, the so called second field tumours [11,12]. Studies differ widely (2-30%) in their estimated risk of SPT development in part due to inconsistencies in patient selection or diagnostic criteria as well as generally inadequate follow up ( [3][4][5][6]8,10,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. It is generally accepted that diagnosis of the index tumour in concert with the premise of field cancerisation imparts a subsequent permanent risk of developing SPT [2][3][4][5][6]20,27].…”

Section: Discussionmentioning

confidence: 99%

Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

Farhadieh¹,

Otáhal²,

Taghavi³

et al. 2011

JCST

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Objective: Second primary tumours (SPT) have been implicated in the dismal overall survival (OS) of head and neck Squamous cell carcinomas (HNSCC). The incidence of SPT, the SPT diagnostic time-lag and the impact on OS were assessed.Subjects and methods: 363 consecutive patients treated for primary oral SCCs (1967SCCs ( -2004 were analyzed retrospectively in this study. 95.1% and 90.5% of patients reached a minimum follow-up period of 3 and 5 years respectively.Results: Of 363 patients; 68 (18.7%) were diagnosed with metachronous SPT, 49 (13.5%) developed upper aerodigestive tract (UAD)-SPT, 28 (7.7%) were diagnosed with HNSCC-SPT, and 21 (5.8%) developed lung or esophageal carcinoma. Patients with subsequent HNSCC-SPT had a better median survival during follow-up than those not diagnosed with SPTs (p=0.0018). The rate of mortality in these patients showed a substantial increase compared to patients with no subsequent SPT Diagnosis after 144 months. After 200 months the survival experience was no better than those without SPT. Conclusion:These results suggest a better OS for patients afflicted with HNSCC-SPT. This also reflects that at least some of the noted improved OS of HNSCC-SPT patients is due to temporally cumulated risk associated with developing SPT.

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“…Accord ing to various studies, the frequency of the second primary cancer in the bronchial tree varies from 1.5% to 7.1% [6,[18][19][20] (table II). Our higher frequency of 12.5%, could be explained by the systematic peri odical examination of the patients.…”

Section: Discussionmentioning

confidence: 99%

Lung Cancer in Patients with Tracheostomy due to Cancer of the Larynx

Castella¹,

Puzo²,

Andrés

et al. 1984

Respiration

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During 3 years, a prospective study was undertaken to investigate the frequency of lung cancer (LC) in patients with a tracheostomy after laryngectomy for neoplasm of the larynx (LxC). The protocol required a thorax radiography (RX) and a bronchofiberscopy (BF) every 6 months in each patient. Of the 286 cases studied, a diagnosis of LC was made in 36 (12.5%). In 6 of these 36 patients, there were no symptoms suggestive of LC and the RX was normal, and the diagnosis of LC was made only by systematic BF. A surgical treatment of LC was possible in only 7 cases. These results suggest that there is a high frequency of LC in patients with tracheostomy due to LxC, and also that it would be better to restrict the follow-up with systematic BF to those patients suitable for thoracotomy

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Occurrence of Additional Primary Neoplasms in Patients with Laryngeal Carcinoma in Israel (1960–1976)

Cited by 32 publications

References 26 publications

Laryngeal carcinoma in black patients

Laryngeal carcinoma in black patients

Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

Lung Cancer in Patients with Tracheostomy due to Cancer of the Larynx

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