Occurrence of Anaemia in the First Year of Inflammatory Bowel Disease in a European Population-based Inception Cohort—An ECCO-EpiCom Study

Burisch, Johan; Végh, Zsuzsanna; Katsanos, K.; Christodoulou, Dimitrios; Lazăr, Daniela; Goldiş, Adrian; O’Moráin, Colm; Fernández, Alberto; Pereira, Santos; Myers, Sally; Sebastian, Shaji; Pedersen, Natalia; Olsen, J; Nielsen, K R; Schwartz, Doron; Odes, Selwyn; Almér, Sven; Halfvarson, Jonas; Turk, Nikša; Cukovic-Cavka, S.; Nikulina, Inna; Belousova, Elena; Ďuricová, Dana; Bortlík, Martin; Shonová, Olga; Salupere, Riina; Barros, Louisa; Magro, Fernando; Jonaitis, Laimas Virginijus; Kupčinskas, Limas; Turcan, Svetlana; Kaimakliotis, Ioannis; Ladefoged, Karin; Kudsk, Karen; Andersen, Vibeke; Vind, Ida; Thorsgaard, Niels; Oksanen, Pia; Collin, Pekka; Piaz, Giulia Dal; Santini, A.; Niewiadomski, Ola; Bell, Sally; Moum, Bjørn; Arebi, Naila; Kjeldsen, Jens; Carlsen, Katrine; Langholz, Ebbe; Lakatos, László; Gerdes, Lars Ulrik

doi:10.1093/ecco-jcc/jjx077

Cited by 27 publications

(27 citation statements)

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“…Despite current guidelines, only 64% of the patients in this cohort received specific therapy within 3 months of the diagnosis of anaemia. Unfortunately, this is in line with other studies reflecting real‐life IBD practices . In a recent cross‐sectional study, Voegtlin et al reported that only 40% and 43% of IBS patients with anaemia in Switzerland, in private practice and university hospitals, respectively, received supplementation therapy .…”

Section: Discussionsupporting

confidence: 79%

“…Similar to a recent European multicentre study of patients with newly diagnosed IBD, we found that Crohn's disease patients with stricturing disease behaviour had an increased risk of anaemia as compared to patients with an inflammatory phenotype, and that extensive disease was associated with an increased risk of anaemia in ulcerative colitis . In contrast, we could not confirm that there was an increased risk in Crohn's disease patients with a colonic disease location, although the predictors of anaemia at the time of diagnosis of IBD may be different from the risk factors in the long term.…”

Section: Discussioncontrasting

confidence: 76%

“…In these populations, the prevalence appears to be high in patients admitted to hospital (≈ 70%) and in newly diagnosed patients (≈ 65%), whereas the occurrence appears to be lower in out‐patients (≈ 20%) and in patients with an established IBD (≈ 35%) . A high prevalence of anaemia at the time of diagnosis has been confirmed by recent population‐based studies, whereas there are unfortunately few population‐based data on the occurrence of anaemia in patients with established IBD . Furthermore, the vast majority of previous studies have only investigated the prevalence of anaemia, and to our knowledge, no general population‐based study has been performed to determine the incidence of anaemia in IBD .…”

Section: Introductionmentioning

confidence: 95%

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Incidence, prevalence and clinical outcome of anaemia in inflammatory bowel disease: a population‐based cohort study

Eriksson

Henriksson

Brus

et al. 2018

Aliment Pharmacol Ther

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SummaryBackgroundThe incidence and short‐term outcome of anaemia in inflammatory bowel disease (IBD) are largely unknown.AimTo determine the incidence, prevalence and clinical outcome of anaemia in terms of resolution of anaemia within 12 months. We also planned to assess risk factors for anaemia in IBD.MethodsA random sample of 342 patients was obtained from the population‐based IBD cohort of Örebro University Hospital, Sweden, consisting of 1405 patients diagnosed between 1963 and 2010. Haemoglobin measurements recorded from 1 January 2011 to 31 December 2013 were extracted from the Clinical Chemistry data system.ResultsIn Crohn's disease, the incidence rate of anaemia was 19.3 (95% CI: 15.4‐23.7) per 100 person‐years and the prevalence was 28.7% (CI: 22.0‐36.2), compared with 12.9 (CI: 9.8‐16.5) and 16.5% (CI: 11.2‐22.9) for ulcerative colitis. Crohn's disease was associated with an increased incidence (OR = 1.60; CI: 1.02‐2.51) and prevalence of anaemia (OR = 2.04; CI: 1.20‐3.46) compared to ulcerative colitis. Stricturing disease phenotype in Crohn's disease (HR = 2.59; CI: 1.00‐6.79) and extensive disease in ulcerative colitis (HR = 2.40; CI: 1.10‐5.36) were associated with an increased risk of anaemia. Despite a higher probability of receiving specific therapy within 3 months from the diagnosis of anaemia, Crohn's disease patients had a worse outcome in terms of resolution of anaemia within 12 months (56% vs 75%; P = 0.03).ConclusionsAnaemia is a common manifestation of IBD even beyond the first years after the diagnosis of IBD. Crohn's disease is associated with both an increased risk and a worse outcome.

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Section: Discussionsupporting

confidence: 79%

Section: Discussioncontrasting

confidence: 76%

Section: Introductionmentioning

confidence: 95%

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Incidence, prevalence and clinical outcome of anaemia in inflammatory bowel disease: a population‐based cohort study

Eriksson

Henriksson

Brus

et al. 2018

Aliment Pharmacol Ther

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“…In an observational cross-sectional multicenter study including 1,313 adult Portuguese IBD patients with a median follow-up after diagnosis of 7 years, anemia was reported in 244 patients, representing a prevalence of 18.6% (95% CI 16.6−20.9) [15]. In another multicenter study including a cohort of 1,871 adult patients, the prevalence of anemia was 49% in CD patients versus 39% in UC patients during the first 12 months after diagnosis [16].…”

Section: Introductionmentioning

confidence: 95%

Portuguese Consensus on Diagnosis, Treatment, and Management of Anemia in Pediatric Inflammatory Bowel Disease

Lopes

Azevedo

Cabral

et al. 2020

GE Port J Gastroenterol

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Anemia is a common extraintestinal manifestation of inflammatory bowel disease (IBD), both in pediatric and in adult patients. Iron deficiency is the main cause of anemia in patients with IBD. Anemia is a clinically relevant comorbidity, with impact on patients' quality of life and it should be timely diagnosed and adequately treated. Currently, an active treatment approach is the recommended strategy, with evidence showing efficacy and safety of intravenous iron formulations. However, evidence in pediatric age remains scarce and no clinical recommendations exist for the diagnosis and treatment of this particular age group. The present document represents the first national consensus on the management of anemia in pediatric IBD and is therefore particularly relevant. The authors anticipate that the proposed recommendations will be useful in daily clinical practice for diagnosing and managing iron deficiency and iron-deficiency anemia in the pediatric population with IBD. ResumoA anemia é uma manifestação extra-digestiva frequente associada à doença inflamatória intestinal, tanto na população pediátrica como adulta, sendo a anemia por défice de ferro a sua forma mais frequente. Constitui uma comorbilidade clinicamente relevante, com repercussão na qualidade de vida. Deve ser atempadamente diagnosticada e adequadamente tratada. A estratégia terapêutica atualmente aceite preconiza uma atitude interventiva. Neste contexto, a evidência científica atual tem demonstrado a eficácia e segurança da utilização das formulações de ferro endovenoso. Contudo, em idade pediátrica a evidência ainda é insuficiente, não existindo orientações de abordagem diagnóstica ou terapêutica especificamente dirigidas a este grupo etário. Este é o primeiro consenso nacional sobre a abordagem da anemia na doença inflamatória intestinal pediátrica, revestindo-se por isso de particular relevância. Pretende-se que este documento tenha utilidade e aplicabilidade na prática clínica na avaliação e seguimento do défice de ferro e anemia por défice de ferro em doentes pediátricos com doença inflamatória intestinal.

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“…A study on the incidence of anaemia in IBD patients published by ECCO (European Crohn's and Colitis Organisation) showed that in 42% of them anaemia was found in the first year after diagnosis. It is more often found in CD patients than in UC patients [91]. e authors of numerous studies describe the relationship of hepcidin-to-iron concentration [92].…”

Section: Ironmentioning

confidence: 99%

The Influence of Nutrients on Inflammatory Bowel Diseases

Jarmakiewicz-Czaja

Piątek

Filip

2020

Journal of Nutrition and Metabolism

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Inflammatory bowel diseases is a group of inflammatory diseases. e pathogenesis of diseases is multifactorial, which may include a Western-type diet. Diseases occur with periods of recurrence and remission. Many factors can have a beneficial effect on reducing the frequency of recurrence and prolonging the remission period. Such ingredients include dietary fibre, mono-and polyunsaturated fatty acids, certain vitamins (D, C, and E), flavonoids, and minerals such as zinc and selenium. Properly selected nutrition might be an integral part of the treatment of patients with Crohn's disease or ulcerative colitis.

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Occurrence of Anaemia in the First Year of Inflammatory Bowel Disease in a European Population-based Inception Cohort—An ECCO-EpiCom Study

Abstract: Overall, 42% of patients had at least one instance of anaemia during the first year following diagnosis. Most patients were assessed for anaemia regularly; however, a full anaemia work-up was frequently neglected in this community setting.

Cited by 27 publications

References 25 publications

Incidence, prevalence and clinical outcome of anaemia in inflammatory bowel disease: a population‐based cohort study

Incidence, prevalence and clinical outcome of anaemia in inflammatory bowel disease: a population‐based cohort study

Portuguese Consensus on Diagnosis, Treatment, and Management of Anemia in Pediatric Inflammatory Bowel Disease

The Influence of Nutrients on Inflammatory Bowel Diseases

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