Occurrence of pharmaceuticals in the Danube and drinking water wells: Efficiency of riverbank filtration

Kondor, A.; Jakab, Gergely; Vancsik, Anna; Filep, Tibor; Szeberényi, József; Szabó, László Z.; Maász, Gábor; Ferincz, Árpád; Dobosy, Péter; Szalai, Zoltán

doi:10.1016/j.envpol.2020.114893

Cited by 57 publications

(19 citation statements)

References 73 publications

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“…In the Danube, 10 PhACs were present in >80% of the samples, whereas carbamazepine was found in 106 Danube samples. In contrast, 10% of the samples were free from carbamazepine in the DWAWs [1] .…”

Section: Data Descriptionmentioning

confidence: 88%

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Dataset of pharmaceuticals in the Danube and related drinking water wells in the Budapest region

et al. 2020

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The present dataset provides data on the pharmaceutically active compounds (PhACs) concentrations measured in the Danube and the drinking water abstraction wells (DWAW) in the Budapest region. Grab samples were collected during five periods. One hundred and seven water samples from the Danube and ninety water samples from the relevant DWAWs were analyzed to quantify physical-chemical parameters, trace element concentrations, and one hundred and eleven PhACs, including pharmaceutical derivatives, illicit drugs, and alkaloids. The ion concentrations were measured using dual channel ion chromatography, spectrophotometric and titrimetric methods, and inductively coupled plasma mass spectrometry. PhACs concentrations were measured after solid-phase extraction applying supercritical fluid chromatography coupled with tandem mass spectrometry. Fifty-two PhACs were quantified in the Danube, and ten PhACs were present in >80% of the samples. Whereas thirty-two PhACs were quantified in the DWAWs. The present dataset is useful for further comparisons and meta-analyses.

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Section: Data Descriptionmentioning

confidence: 88%

“…The method characteristics, limits of detection, and quantification values are given by Kondor et al. [1] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Dataset of pharmaceuticals in the Danube and related drinking water wells in the Budapest region

et al. 2020

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“…Details of the sample preparation, extraction and analysis process for PhACs have also been described in our earlier papers (Jakab et al, 2020;Kondor et al, 2020;Maasz et al, 2019). Briefly, for sample quantification, the water samples were acidified with formic acid and spiked with the corresponding mass-labelled internal standard (IS).…”

Section: Water Sampling and Chemical Analysismentioning

confidence: 99%

Effects of pharmaceutically active compounds (PhACs) on fish body and scale shape in natural waters

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Dobosy

Maász

et al. 2021

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Background In recent years, there are growing concerns about pharmaceutically active compounds (PhACs) in natural ecosystems. These compounds have been found in natural waters and in fish tissues worldwide. Regarding their growing distribution and abundance, it is becoming clear that traditionally used risk assessment methodologies and ecotoxicological studies have limitations in several respects. In our study a new, combined approach of environmental impact assesment of PhACs has been used. Methods In this study, the constant watercourses of the suburban region of the Hungarian capital (Budapest) were sampled, and the body shape and scale shape of three fish species (roach Rutilus rutilus, chub Squalius cephalus, gibel carp Carassius gibelio) found in these waters were analyzed, based on landmark-based geometric morphometric methods. Possible connections were made between the differences in body shape and scale shape, and abiotic environmental variables (local- and landscape-scale) and measured PhACs. Results Significant connections were found between shape and PhACs concentrations in several cases. Despite the relatively large number of compounds (54) detected, citalopram, propranolol, codeine and trimetazidine significantly affected only fish body and scale shape, based on their concentrations. These four PhACs were shown to be high (citalopram), medium (propranolol and codeine), and low (trimetazidine) risk levels during the environmental risk assessment, which were based on Risk Quotient calculation. Furthermore, seven PhACs (diclofenac, Estrone (E1), tramadol, caffeine 17α-Ethinylestradiol (EE2), 17α-Estradiol (aE2), Estriol (E3)) were also categorized with a high risk level. However, our morphological studies indicated that only citalopram was found to affect fish phenotype amongst the PhACs posing high risk. Therefore, our results revealed that the output of (traditional) environmental/ecological risk assessment based on ecotoxicological data of different aquatic organisms not necessarily show consistency with a “real-life” situation; furthermore, the morphological investigations may also be a good sub-lethal endpoint in ecotoxicological assessments.

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“…Furthermore, several surveys along shorter sections of the Danube River monitoring certain contaminants classes relieved dynamic and regional particularities of the pollution [9][10][11][12][13][14]. Thus, different monitoring studies identified several classes of contaminants such as: pharmaceuticals [10,13,15,16], personal care products [17,18], endocrine disruptors [19][20][21][22][23], pesticides [2,22], polycyclic aromatic hydrocarbons [11,22], polychlorinated biphenyls [22], heavy metals [22,24,25], and microbiological contaminants [8].…”

Section: Introductionmentioning

confidence: 99%

Emerging and Persistent Pollutants in the Aquatic Ecosystems of the Lower Danube Basin and North West Black Sea Region—A Review

et al. 2021

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The tremendous impact of natural and anthropogenic organic and inorganic substances continuously released into the environment requires a better understanding of the chemical status of aquatic ecosystems. Water contamination monitoring studies were performed for different classes of substances in different regions of the world. Reliable analytical methods and exposure assessment are the basis of a better management of water resources. Our research comprised publications from 2010 regarding the Lower Danube and North West Black Sea region, considering regulated and unregulated persistent and emerging pollutants. The frequently reported ones were: pharmaceuticals (carbamazepine, diclofenac, sulfamethoxazole, and trimethoprim), pesticides (atrazine, carbendazim, and metolachlor), endocrine disruptors—bisphenol A and estrone, polycyclic aromatic hydrocarbons, organochlorinated pesticides, and heavy metals (Cd, Zn, Pb, Hg, Cu, Cr). Seasonal variations were reported for both organic and inorganic contaminants. Microbial pollution was also a subject of the present review.

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Occurrence of pharmaceuticals in the Danube and drinking water wells: Efficiency of riverbank filtration

Cited by 57 publications

References 73 publications

Dataset of pharmaceuticals in the Danube and related drinking water wells in the Budapest region

Dataset of pharmaceuticals in the Danube and related drinking water wells in the Budapest region

Effects of pharmaceutically active compounds (PhACs) on fish body and scale shape in natural waters

Emerging and Persistent Pollutants in the Aquatic Ecosystems of the Lower Danube Basin and North West Black Sea Region—A Review

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