OCDB: a database collecting genes, miRNAs and drugs for obsessive-compulsive disorder

Privitera, Anna; Distefano, Rosario; Wefer, Hugo; Ferro, Alfredo; Pulvirenti, Alfredo; Giugno, Rosalba

doi:10.1093/database/bav069

Cited by 20 publications

(15 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dysregulations in the major stress systems (cortico–strial–thalamic–cortical circuits and inflammatory functions) have been demonstrated in OCD and these could be contributing to increased oxidative stress. Oxidative stress is closely related to the inflammatory pathway in particular.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Alici¹,

Bülbül

Virit

et al. 2015

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Aims: There are limited published data about the role of oxidative stress in the pathophysiology of obsessive-compulsive disorder (OCD). In addition, oxidative stress and oxidative DNA damage have not been investigated together in OCD. In this study, we aimed to evaluate oxidative stress and oxidative DNA damage in patients with OCD.Methods: Forty-two patients with OCD who were diagnosed in the Psychiatry Clinic of Gaziantep University and 38 healthy volunteers were enrolled in the study. Serum 8-hydroxideoxiguanosine (8-OHdG), total antioxidant status, total oxidant status evaluation and oxidative stress index calculation were conducted in Gaziantep University Biochemical Laboratory.Results: There were no significant differences in the total antioxidant status, total oxidant status and oxidative stress index levels between the patients and control group. However, 8-OHdG levels were significantly higher in OCD patients than controls (P = 0.022). In addition, 8-OHdG levels were significantly lower in patients who took treatment than in patients who were newly diagnosed (P = 0.016). Conclusions:In our study, we found that oxidative DNA damage increased in OCD patients even though oxidative stress was normal. In addition, DNA damage was lower in patients who were treated compared to those without treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Alici¹,

Bülbül

Virit

et al. 2015

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…Several tools have also been developed to directly link miRNAs to biological processes such as DMirNet [188], miRnet [110] and DIANA-miRPath v3.0 [107]. Many tools and resources have also been developed to link miRNAs to speciic phenotypes/environments including diseases such as miRNAs in obsessive-compulsive disorder [189], autophagy in gerontology [190], epilepsy [191] and cancer [192]. Among the most popular integrated tools, DIANA-tools (www.microrna.gr) covers a wide scope and research scenarios integrating several tools such as DIANA-microT-CDS, DIANA-TarBase v7.0, DIANA-miRGen v3.0, DIANA-miRPath v3.0, and DIANA-mirExTra v2.0.…”

Section: Integrated Tools For Mirna Analysismentioning

confidence: 99%

Transcriptome Analysis of Non‐Coding RNAs in Livestock Species: Elucidating the Ambiguity

Ngoc¹,

Dudemaine²,

Fomenky³

et al. 2017

Applications of RNA-Seq and Omics Strategies - From Microorganisms to Human Health

View full text Add to dashboard Cite

The recent remarkable development of transcriptomics technologies, especially next generation sequencing technologies, allows deeper exploration of the hidden landscapes of complex traits and creates great opportunities to improve livestock productivity and welfare. Non-coding RNAs (ncRNAs), RNA molecules that are not translated into proteins, are key transcriptional regulators of health and production traits, thus, transcriptomics analyses of ncRNAs are important for a beter understanding of the regulatory architecture of livestock phenotypes. In this chapter, we present an overview of common frameworks for generating and processing RNA sequence data to obtain ncRNA transcripts. Then, we review common approaches for analyzing ncRNA transcriptome data and present current state of the art methods for identiication of ncRNAs and functional inference of identiied ncRNAs, with emphasis on tools for livestock species. We also discuss future challenges and perspectives for ncRNA transcriptome data analysis in livestock species.

show abstract

“…[1] The WHO has ranked it as one of the 10 debilitating medical conditions. [2] The main symptoms of this disease are obsession and compulsion, which involves unwanted and disturbing thoughts, ideas or sensations. The OCD is the result of the usual concerns about the problems of life in which a person considers them to be the result of his own mind.…”

Section: Introductionmentioning

confidence: 99%

Using caffeine on the patients as therapeutic option against treatment-resistant obsessive-compulsive disorder

Shams

Soufi

Zahiroddin

et al. 2019

J Family Med Prim Care

View full text Add to dashboard Cite

Introduction: Obsessive-compulsive disorder (OCD) is one of the most common and debilitating diseases. Approximately 40-30% of these patients are resistant to treatment, which auxiliary drugs are used to treat these patients. One of these drugs is caffeine, which is capable of affecting adenosine receptors and interfering with its release and serotonin reuptake. Considering the limitations of previous studies in this area, including lack of control group, this double-blind study compared the effectiveness of caffeine in the management of patients with treatment-resistant OCD in comparison with placebo group. Materials and Methods: 62 patients who referred to the psychiatric clinic of Imam Hossein Hospital in Tehran from 2017 to 2018 were enrolled in the study. According to the psychiatrist's interview, patients with OCD were selected randomly in two groups including caffeine and placebo, after having met the criteria for inclusion and obtaining informed consent. Patients were followed for 8 weeks and compared in terms of the severity of OCD before and after intervention using YBOCS questionnaire. Results: The two groups of treatment and control were similar in terms of study variables (gender, age, education, age, comorbidity). The mean Yale-Brown Obsessive Compulsive Scale (Y-BOCS) in the treatment and control groups before intervention were determined to be 27.16 and 25.4, respectively, which changed to 24 and 27.23 after medication intervention, which exhibited a decrease of about 3 points (12%) in the treatment group, and was statistically significant based on linear regression analysis ( P = 0.009). Considering other variables, the effect of caffeine was still statistically significant in the two groups. Conclusion: Based on the findings of our study, caffeine can reduce the severity of the symptoms of OCD and serve as an auxiliary treatment for OCD.

show abstract

OCDB: a database collecting genes, miRNAs and drugs for obsessive-compulsive disorder

Cited by 20 publications

References 75 publications

Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Transcriptome Analysis of Non‐Coding RNAs in Livestock Species: Elucidating the Ambiguity

Using caffeine on the patients as therapeutic option against treatment-resistant obsessive-compulsive disorder

Contact Info

Product

Resources

About