Oct angiography compared to fluorescein angiography, indocyanine green angiography and optical coherence tomography in the detection of choroidal neovascularization in pigment epithelial detachment

Abstract

Purpose To evaluate the agreement between multimodal imaging—MI (fluorescein angiography, indocyanine green angiography, optical coherence tomography) and optical coherence tomography angiography (OCTA) in the detection of choroidal neovascularization (CNV) in patients with pigment epithelial detachment with subretinal/intraretinal fluid (PED+F) compared to patients with PED without subretinal/intraretinal fluid (PED‐F). Methods Twenty‐two eyes of 15 patients were divided into two groups (PED+F and PED‐F). All patients underwent MI and OCTA with manual and automatic segmentation. MI findings were compared to OCTA findings and then analysed. Results In the PED+F group (10 eyes), all studied eyes demonstrated CNV in MI. In manual segmentation OCTA assessment, 9 of 10 eyes (90%) were detected with CNV. When evaluated by automatic segmentation, 8 of 10 eyes (80%) revealed the presence of CNV. In the PED‐F (12 eyes) group, all eyes did not demonstrate CNV in MI and OCTA evaluations, either by manual or automatic segmentation. The agreement between MI and OCTA shows concordance (k: 0.908; 95% CI, 0.491–1.000); the evaluation of the agreement between the automatic and manual segmentation also shows concordance (k: 0.904; 95% CI, 0.488–1.000). Conclusion The solid agreement between the multimodal imaging regarding the ability of OCTA to identify possible initial CNV in a patient with PED‐F was observed. Accuracy was 95.45%. In addition, the agreement between manual and automatic segmentation to identify CNV on OCTA was also shown.

Gold Nanorod Enhanced Photoacoustic Microscopy and Optical Coherence Tomography of Choroidal Neovascularization

“…CNV is currently monitored using FA, ICGA, OCT, and OCTA. FA and ICGA can provide the location of CNV via leakage after injection of fluorescent chromophores. − However, these imaging techniques cannot provide in-depth information of the vascular network. In addition, the margin of CNV could not be identified clearly due to the extravasation of the fluorescent compound over time postinjection.…”

“…In addition, the margin of CNV could not be identified clearly due to the extravasation of the fluorescent compound over time postinjection. OCT and OCTA could provide more information of the vasculature in both 2D and 3D with great image contrast. ,, A weakness of OCTA is that it is based on the motion of blood flow, and thus, it has limited sensitivity to detect the slow flow of red blood cells within the neoangiogenic choroidal capillaries, resulting in difficulties to detect the precise location of CNV. Comparing these imaging systems, PAM offers several advantages such as greater penetration depth and 3D imaging capability.…”