Ocular changes in patients with psoriasis

Demerdjieva, Zdravka; Mazhdrakova, Iskra; Tsankov, Nikolaï

doi:10.1016/j.clindermatol.2019.07.029

Cited by 26 publications

(53 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, it is hypothesized that the ocular manifestations are closely associated with the cutaneous manifestations through an immune-mediated mechanism. Skin histology appears to be similar to ocular histology (parakeratosis), particularly in cases where psoriatic lesions are observed at the level of the eyelids or the conjunctiva (5,6).…”

Section: Etiopathogenesismentioning

confidence: 73%

“…The most common clinical ocular change associated with psoriasis is keratoconjunctivitis sicca (dry eye syndrome), which is present in 18.75% of patients, and blepharitis (2,12,13). Other changes include conjunctivitis, uveitis, punctate keratitis, pinguecula, cataracts, glaucoma, corneal abscesses, pterygium, or abnormalities of retinal vascularization (5,14). An uncommon condition that may also develop is pigment dispersion syndrome, which is characterized by shedding of the pigment from the posterior surface of the iris into the anterior segment following the flow of aqueous humour.…”

Section: Ophthalmological Changesmentioning

confidence: 99%

“…Patients exhibit hyperemia, inflammation and edema at the free margin of the eyelids, with slight scaling, itching and burning sensation (1,6,13). Chronic blepharitis may lead to ectropion of the lower lacrimal point with epiphora, madarosis, trichiasis and loss of lid tissue (5,13) or meibomian gland dysfunction, which is frequently associated with posterior blepharitis.…”

Section: Ophthalmological Changesmentioning

confidence: 99%

See 2 more Smart Citations

Psoriasis beyond the skin: Ophthalmological changes (Review)

et al. 2021

View full text Add to dashboard Cite

Psoriasis is a chronic, immune-mediated inflammatory disease of unknown etiology that may be associated with abnormal T-lymphocyte function. Ocular manifestations associated with psoriasis, particularly artropathic or pustular psoriasis, usually affect men, often during exacerbations of the disease. It has been reported that eye damage tends to occur later compared with cutaneous or joint manifestations, blindness being the most disabling complication. Previous studies have focused on ophthalmic manifestations and identified several etiopathogenic mechanisms. Psoriasis may be associated with eye complications such as lesions of the eyelids, conjunctiva and others, with systemic inflammation being the main contributor. In addition, the treatment used for psoriasis may cause ocular changes. The main ophthalmic manifestations associated with psoriasis are keratoconjunctivitis sicca, blepharitis, conjunctivitis and uveitis. The treatment of uveitis, perceived as one of the most serious eye conditions, is controversial and has yet to be clearly determined. Thus, the aim of the present review was to emphasize the importance of regular eye examination for patients with psoriasis, either those receiving biological treatment or those not receiving treatment, in order to diagnose and manage the disease appropriately.

show abstract

Section: Etiopathogenesismentioning

confidence: 73%

Section: Ophthalmological Changesmentioning

confidence: 99%

Section: Ophthalmological Changesmentioning

confidence: 99%

See 1 more Smart Citation

Psoriasis beyond the skin: Ophthalmological changes (Review)

et al. 2021

View full text Add to dashboard Cite

show abstract

“…11 Possible etiopathogenetic mechanisms that may contribute to the development of ophthalmic manifestations include complications of psoriasis treatments, such as oral retinoids and phototherapy, direct eye involvement with psoriatic plaques, and psoriasis-related inflammation. [28][29][30][31][32] Immunopathogenesis of uveitis has also been demonstrated to be dependent on T H 17-and T H 1-dependent immune responses, where disease activity correlates with increases in IL-17 in aqueous humor of uveitis patients. 33 Other inflammatory factors that have been linked to the pathogenesis of psoriasis such as tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2) and IL-6 have also been found to be increased in the aqueous humor in uveitis patients.…”

Section: Discussionmentioning

confidence: 99%

The Incidence and Prevalence of Uveitis in Psoriasis: A Systematic Review and Meta-Analysis

Lam

Steen

et al. 2020

J Cutan Med Surg

View full text Add to dashboard Cite

Background The systemic effects and comorbidities of psoriasis include ocular disorders, such as uveitis. Patients with psoriatic arthritis in particular have been demonstrated to have an elevated risk for developing uveitis. Presently, the risk of uveitis in psoriasis has yet to be fully elucidated and this systematic review seeks to address this gap. Objective To examine the prevalence and incidence of uveitis in psoriasis patients compared to non-psoriasis patients. Methods We conducted a systematic review search on MEDLINE, Embase, and CENTRAL electronic databases with no lower limit on year of publication. Results Fourteen articles met our inclusion criteria, with a total of 234 143 psoriasis subjects. Two studies found that participants with severe psoriasis were at a greater risk of uveitis than those with mild psoriasis. A random-effects meta-analysis of the 3 studies, which reported risk of incidence of uveitis in psoriasis patients compared to non-psoriasis controls, found a pooled risk ratio of 1.29 (95% CI, 1.10-1.51), indicating an increased risk of uveitis in psoriasis. Three studies compared risk of uveitis in psoriatic arthritis with psoriasis-only participants, all finding that psoriatic arthritis was associated with a greater risk of uveitis. Conclusions In summary, our findings suggest that psoriasis is associated with an increased risk of uveitis, with or without psoriatic arthritis.

show abstract

“…Ocular findings usually occur bilaterally during exacerbation periods of psoriasis. Furthermore, vision-threatening complications are rare [ 8 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of central retinal thickness, choroidal thickness, and retinal nerve fiber layer in psoriasis: a spectral-domain optical coherence tomography study

2021

View full text Add to dashboard Cite

Background This study aims to evaluate choroidal thickness (CT), retinal thickness, ganglion cell-inner plexiform layer (GCIPL), and retinal nerve fiber layer (RNFL) structures in psoriasis patients using optical coherence tomography (OCT). Methods This study included 33 psoriasis patients and 33 healthy individuals. Moreover, psoriasis patients who did not use any systemic anti-inflammatory treatment were evaluated. Retinal and choroidal images of the participants were obtained with spectral-domain OCT. Furthermore, CT was measured in the subfoveal, temporal, and nasal positions at 500-µm intervals to a distance of 1,500 μm from the foveal center. Results The mean psoriasis area and severity index (PASI) score was 5.70 (range, 2.40–9.00). No significant differences were found in subfoveal (p = 0.659), temporal, and nasal CT values in psoriasis patients compared with the control group (p > 0.05). Similarly, no statistically significant differences were found between the groups in terms of central retinal thickness, macular GCIPL, and RNFL (p > 0.05). Moreover, no significant correlation exists between the duration of psoriasis disease and PASI scores and OCT parameters (p > 0.05). Conclusions No significant changes in CT, ganglion cell layer, RNFL, and retinal thickness values were noted in psoriasis patients with mild to moderate mean PASI score.

show abstract

Ocular changes in patients with psoriasis

Cited by 26 publications

References 53 publications

Psoriasis beyond the skin: Ophthalmological changes (Review)

Psoriasis beyond the skin: Ophthalmological changes (Review)

The Incidence and Prevalence of Uveitis in Psoriasis: A Systematic Review and Meta-Analysis

Assessment of central retinal thickness, choroidal thickness, and retinal nerve fiber layer in psoriasis: a spectral-domain optical coherence tomography study

Contact Info

Product

Resources

About