Ocular Findings in Patients with Dysplastic Nevus Syndrome

New insights into oculodermal nevogenesis and proposal for a new iris nevus classification

“…Applying the currently established defintions to distinguish between solitary (involving a discret portion of the iris) and sectoral (involving an entire sector) iris nevi, all our iris nevi were classified as solitary 3 4. In line with previous studies, we found the majority of solitary iris nevi to be located on the lower half of the iris as well as an association with dysplastic cutaneous nevi 9. With regard to the current classification, we like to draw attention to the peculiarities of six iris nevi in our sample, which revealed a morphology strikingly reminiscent of an 'incomplete' sectoral nevus.…”

Don’t it make my blue eyes brown: heterochromia and other abnormalities of the iris

“…Iris naevi appear to be more common in patients with light-coloured irides 47 and individuals with the dysplastic naevus syndrome. 278,279 Clinically, iris naevi may be circumscribed or diffuse in nature and in both forms the lesion effaces or obscures the underlying iris stromal architecture: a feature, which differentiates them from a simple iris ephelis where the architecture is preserved. Circumscribed naevi appear as a well-demarcated lesion, which may vary in size, shape, and degree of pigmentation.…”

Genetic predisposition to ocular melanoma

“…Uveal and conjunctival naevi all occur more commonly in patients with the dysplastic naevus syndrome. 45 Bataille et al 46 examined the skin of 207 consecutive patients with ocular melanoma. Five patients had primary melanoma of the skin (relative risk of cutaneous melanoma 12.5).…”