Ocular perfusion pressure and intraocular pressure in pregnant women with severe preeclampsia

Abstract

Objectives: The aim of this study was to investigate whether severe preeclampsia (SPE) affects intraocular pressure (IOP) and ocular perfusion pressure (OPP). Material and methods: This prospective and comparative study included 64 pregnant females, allocated into 2 groups as Group 1 (31 pregnant women with SPE) and Group 2 (33 normotensive pregnant women). IOP, systolic and diastolic blood pressure, OPP of all the subjects were measured after 20 weeks of gestation and prior to labor and medical therapy. Results: The mean IOP values in Group 1 were not significantly different from those of Group 2 (p = 0.528). The mean OPP values in Group 1 were significantly higher than those of Group 2 (p < 0.001). There was no significant correlation between IOP and OPP levels. No significant differences were determined between the groups in respect of age, gestational age body mass index (BMI) (p < 0.269, p < 0.219 and p < 0.556 respectively). The mean systolic and diastolic blood pressure values were statistically significantly higher in Group 1 than in Group 2 (p < 0.001 and p < 0.001). Conclusions: Although high IOP was expected in SPE patients, it was found to be constant. This could have been due to an increase in aqueous humor outflow because of changes occurring in angiogenic and anti-angiogenic factors in SPE.

Case-control study on ocular changes and ophthalmic Doppler velocimetric indices among preeclamptic and normotensive pregnant women in Ibadan, Nigeria

“… 31 33 34 This study found that intraocular pressure was significantly higher among preeclampsia cases, as reported by previous authors. 18 The ocular parameters in this study were generally similar between the right and left eye, and this similarity has been previously reported. 18 The ocular parameters were similar between women with mild and severe preeclampsia in this study.…”

“… 18 The ocular parameters in this study were generally similar between the right and left eye, and this similarity has been previously reported. 18 The ocular parameters were similar between women with mild and severe preeclampsia in this study. This finding has also been reported by previous studies, 18 but other studies have shown significantly higher mean values for resistivity index and pulsatility index among preeclampsia cases.…”

“… 18 The ocular parameters were similar between women with mild and severe preeclampsia in this study. This finding has also been reported by previous studies, 18 but other studies have shown significantly higher mean values for resistivity index and pulsatility index among preeclampsia cases. 19 There have been inconsistencies in the magnitude and direction of the differences of ocular parameters between preeclampsia cases and controls in previous studies.…”

“… 8 17 Cerebral blood flow velocity is increased in pregnancy-induced hypertension, suggesting an increased resistance to flow. 18 Doppler studies of the orbital vessels give information on intracranial circulation due to the similarities in the embryology, anatomy, and function of orbital and intracranial vessels. 18–20 …”

“… 18 Doppler studies of the orbital vessels give information on intracranial circulation due to the similarities in the embryology, anatomy, and function of orbital and intracranial vessels. 18–20 …”