Ocular symptoms, tear film stability, nasal patency, and biomarkers in nasal lavage in indoor painters in relation to emissions from water-based paint

Wieslander, Gunilla; Norbäck, Dan

doi:10.1007/s00420-010-0552-0

Cited by 49 publications

(24 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When employees reoccupied buildings with high levels of MVOCs after flooding, increased signs of eosinophilic inflammation in the nasal mucosae were observed . Similar results were found among professional house painters, for whom exposed to higher levels of 1-octen-3-ol, a known MVOC, was related to reduced nasal patency and increases in nasal-inflammation biomarkers 6 (Wieslander and Norbäck, 2010). Two studies on MVOC exposure and asthma and allergies in schools found a relationship between MVOC exposure and an increased odds ratio (OR) for the occurrence of wheezing, nocturnal breathlessness, doctor-diagnosed asthma, and history of asthma among pupils and among employees (Kim et al, 2007;Smedje et al, 1996).…”

Section: Microbial Volatile Organic Compounds (Mvocs) Include a Rangesupporting

confidence: 77%

See 1 more Smart Citation

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

Araki

Kanazawa

Kawai

et al. 2012

Science of The Total Environment

View full text Add to dashboard Cite

Microbial volatile organic compounds (MVOCs) are a type of VOCs produced by microorganisms. Exposure to 1-octen-3-ol, one of the known MVOCs, has been reported to reduce nasal patency and increase nasal lavage myeloperoxidase, eosinophil cationic proteins, and lysozymes in both experimental and field studies. We reported in a previous paper that 1-octen-3-ol exposure at home is associated with mucosal symptoms. In this study, our aim was to investigate the relationship between asthma and allergies and MVOC exposure in single-family homes. The subjects were 624 inhabitants of 182 detached houses in six regions of Japan. Air samples were collected using diffusive samplers, and the concentrations of eight selected MVOCs were analyzed using gas chromatography/mass spectrometry in selected-ion-monitoring mode. Each inhabitant of each of the dwellings was given a self-administered questionnaire. Among the 609 subjects who answered all of the questions about allergies, history of the medical treatment for asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis within the past two years was 4.8%, 9.9%, 18.2%, and 7.1 %, respectively. A significant association between 1-octen-3-ol (per log 10 unit) and allergic rhinitis odds ratio (OR): 4.10, 95% confidence interval (CI): 1.71 to 9.80 and conjunctivitis (OR: 3.54, CI: 1.17 to 10.7) was found after adjusting for age, sex, environmental-tobacco-smoke exposure, wall-to-wall carpeting in the home, signs of dampness, history of treatment for hay fever, and other potentially relevant environmental factors. No relationships were found between any MVOCs and asthma or atopic dermatitis after the adjustment. The levels of MVOCs and airborne fungi were only weakly correlated. These results are consistent with previous studies that have associated higher levels of 1-octen-3-ol exposure with increased irritation of nasal 4 and ocular mucosae. Although the indoor-air concentrations of 1-octen-3-ol found in this study were relatively low, we conclude that exposure to MVOC may be related to rhinitis and conjunctivitis.

show abstract

Section: Microbial Volatile Organic Compounds (Mvocs) Include a Rangesupporting

confidence: 77%

“…MVOC concentrations are higher in buildings that have dampness problems caused by flooding than in control buildings (Wieslander and Norbäck, 2010). These results suggest that exposure to MVOCs is one of the possible effects of dampness.…”

Section: Microbial Volatile Organic Compounds (Mvocs) Include a Rangementioning

confidence: 77%

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

Araki

Kanazawa

Kawai

et al. 2012

Science of The Total Environment

View full text Add to dashboard Cite

show abstract

“…Concentrations of SVOCs in indoor air are generally much lower than those of VOCs (Kanazawa et al 2010); however, a number of SVOCs have been detected in indoor dust (Bornehag et al 2005;Meeker and Stapleton 2010;Hoffman et al 2015). In addition, SVOCs, such as plasticizers and flame retardants, have been suggested as causing adverse health effects, including ocular and nasal symptoms and endocrine-disrupting effects (Kojima et al 2009(Kojima et al , 2013Rudel and Perovich 2009;Takeuchi et al 2005b;Wieslander and Norbäck 2010).…”

Section: Introductionmentioning

confidence: 96%

Differential determination of plasticizers and organophosphorus flame retardants in residential indoor air in Japan

Takeuchi

Tanaka-Kagawa

Saito

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

A variety of chemicals have been used in a wide range of indoor materials, such as wallpaper and furniture, and some of them are released into the indoor air. The level of consumption as well as the diversity of these chemicals has been increasing. The particle size of the materials in the air is known to affect the depth of human exposure, e.g., particles >10 μm can only reach the nasal cavity, whereas particles 2.5-10 μm can reach the respiratory tract and particles <2.5 μm can reach the bottom of the lungs. However, information on the concentrations and form of these chemicals in indoor air is very limited. In this study, we measured 54 compounds, including plasticizers (phthalates, adipates, and others) and organophosphorus flame retardants, in indoor air samples from the living rooms of 21 dwellings in 11 prefectures across Japan. For sampling, we used a four-stage air sampler (multi-nozzle cascade impactor) equipped with three quartz fiber filters to capture chemical particulates in three size ranges (<2.5, 2.5-10, and >10 μm) and a C solid-phase extraction disk to capture chemicals that exist in a gas phase in indoor air. Each of the chemicals in the three particulate phases and single gas phase was extracted by acetone and measured separately using GC/MS. Of the 54 compounds tested, 37 were detected in the indoor air samples. The highest concentration observed was that of 2-ethyl-1-hexanol (5.1 μg/m), which was detected in samples from all 21 houses. The 37 compounds were captured in the four fractions at different rates roughly based on their molecular sizes. Compounds with a smaller molecular size were commonly detected as a gas phase, whereas compounds with a larger molecular size were detected as one or more of the three particulate phases in the indoor air samples. Among the three particulate phases, many of the compounds were detected from the filter capturing the smallest (<2.5 μm) particles. Therefore, these results suggest that the chemicals measured in this study might penetrate deeply into the lungs as many of them tend to exist as a gas and/or as particles smaller than 2.5 μm.

show abstract

“…PGTex could induce allergic airway inflammation, heightened production of IL-12, and oxidative stress in allergen sensitized mice (41). Occupational exposures to painted surfaces have been associated with eye irritation, skin itching, obstructive airway problems, and frequent urination in a longitudinal follow-up studies (42)(43)(44)(45)(46)(47). To date, US Environmental Protection Agency posed a significant new rule on 14 of PGTex with known risks (48).…”

Section: Home Indoor Dampnessmentioning

confidence: 99%

Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

Choi

Song

Zhang

2017

Reviews on Environmental Health

View full text Add to dashboard Cite

Abstract Asthma and other complex diseases results from a complex web of interactions involving inflammation, immunity, cell cycle, apoptosis, and metabolic perturbations across multiple organ systems. The extent to which various degrees of the age at onset, symptom severity, and the natural progression of the disease reflect multiple disease subtypes, influenced by unique process of development remains unknown. One of the most critical challenges to our understanding stems from incomplete understanding of the mechanisms. Within this review, we focus on the phenotypes of childhood allergic asthma as the basis to better understand the endotype for quantitative define subtypes of asthma. We highlight some of the known mechanistic pathways associated with the key hallmark events before the asthma onset. In particular, we examine how the recent advent of multiaxial -omics technologies and systems biology could help to clarify our current understanding of the pathway. We review how a large volume of molecular, genomic data generated by multiaxial technologies could be digested to identify cogent pathophysiologic molecular networks. We highlight some recent successes in application of these technologies within the context of other disease conditions for therapeutic interventions. We conclude by summarizing the research needs for the predictive value of preclinical biomarkers.

show abstract

Ocular symptoms, tear film stability, nasal patency, and biomarkers in nasal lavage in indoor painters in relation to emissions from water-based paint

Cited by 49 publications

References 33 publications

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

Differential determination of plasticizers and organophosphorus flame retardants in residential indoor air in Japan

Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

Contact Info

Product

Resources

About