Odor-aversion learning in neonate rat pups: the role of duration of exposure to an odor

Smith, Fred. J.; Charnock, Deborah; Westbrook, R. Frederick

doi:10.1016/s0163-1047(83)91349-3

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…Neonatal mice in which an odor CS was paired with an LiCl injection on P7 learned a conditioned aversion to the odor that persisted for up to 3 days (Alleva and Calamandrei, 1986); while these data demonstrate the capacity of neonatal mice to retain conditioned responses over multiple days, neonatal rats trained on P2 retained a similar odor association with LiCl injection for at least 8 days (Rudy and Cheatle, 1977). Hence, it is likely that outbred (CD-1, Swiss) mice do not retain conditioned odor responses as strongly as do rats under current experimental protocols, though the US modality (nutritive vs. tactile) may also contribute to observed differences among studies (Bouslama et al, 2005), as may the longer (1 h) periods of CS-US pairing utilized by Alleva and Calamandrei (1986) and the present study (Smith et al, 1983).…”

Section: Discussionmentioning

confidence: 56%

One-Trial Associative Odor Learning in Neonatal Mice

2006

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Behavior genetics studies in mice demand efficient training protocols for rapid phenotypic screening. However, the capacity of neonatal mice to form and retain associative memories has been difficult to study due to their limited sensorimotor capacities. The present study describes a method for robust, naturalistic associative learning in neonatal mice as young as 3 days old. After removal of the dam from the home cage for 2 h, preweanling CD-1 mice of ages 3, 5, and 10 days postnatal were conditioned to associate an arbitrary odorant with the suckling and milk delivery that ensued upon her return to the home cage. After a second maternal deprivation, neonates were tested on their acquired preference for that odorant. Neonates exhibited a learned preference for the conditioned odorant over a novel control odorant. No learning was observed without deprivation, that is, when the dam was removed only briefly for scenting. One-trial learning sufficed to show clear preferences for the conditioned odorant, although repeated training (three sessions over 8 days) significantly increased the expression of preference. The development of neonatal associative learning protocols requiring minimal human intervention is important for the behavioral phenotyping of mutant and transgenic strains, particularly those modeling developmental disorders.

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Section: Discussionmentioning

confidence: 56%

One-Trial Associative Odor Learning in Neonatal Mice

2006

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“…Intertrial length (Gray et al, 1967) and the duration of CS/US intervals were examined by several authors Smith et al, 1983;Rudy and Cheatle, 1979;Gemberling et al, 1980). Rat pups younger than five to six days did not seem to show "long delayed learning," i.e., the capability to associate CS preexposure to US if they are separated by a long time interval.…”

Section: Conditions Under Which Csajs Pairing Occursmentioning

confidence: 99%

Early Learning Capability in Rodents: A Review (<em>Rattus Norvegicus and Mus Musculus</em>)

Alleva¹,

D’Udine²

1987

International Journal of Comparative Psychology

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Available data on learning capabilities in immature rodents are briefly summarized and some new findings on early learning in mice are presented. We omit the comparatively small number of works concerning precocial species of rodents, that is, guinea pigs and spiny mice. In a comparison we have already made (D'Udine and we found that rodent species characterized as precocial types appeared to be affected in a dramatic way by environmental factors during postnatal development, as shown by profound modification of their adult behavioral patterns. Since the aim of our contribution is to review the methodological paradigms used to assess early learning capabilities in rodents, we shall focus here on the Norway rat and the house mouse, because they are the only species for which evidence has progressively been built up through the use of different tests. SOMMARIO: I roditori di laboratorio hanno rappresentato storicamente U materiale di base sul quale sono stati sviluppati i paradigmi sperimentaU dell' "apprendimento"animale. E' stata posta relativamente troppa attenzione su un numero estremamente ridotto di specie, per di piii tra loro simili, il che ha causato parecchie restrizioni nel definire leggi piu general! sull'apprendimento. Tale atteggiamento ^stato criticato ma ci si ^occupati molto meno di un altro tipo di distorsione causata daU'uso di animali adulti, e della conseguente costruzione di modelli molto poco validi per stadi immaturi.Un esame critico della letteratura mostra che con I'uso di saggi appropriati possono essere evidenziate capacity di apprendimento anche nel periodo perinatale. Vengono anche discussi aspetti comparativi e altri riguardanti lo sviluppo ontogenetico nelle specie ratto e topo.Sono riportati alcuni dati originali nel topo, specie sulle cui capacity neonatali di apprendimento e ritenzione esistevano solo risultati negativi.ONTOGENY of LEARNING and RETENTION CAPABILITIES in the NORWAY RAT (Rattus Norvegicus) We have restricted our field of interest to the preweaning period as far as the rat is concerned. Learning capabilities in the rat around

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Conditioned taste aversion and traditional learning

Klosterhalfen

1985

Psychol. Res

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Odor-aversion learning in neonate rat pups: the role of duration of exposure to an odor

Cited by 7 publications

References 13 publications

One-Trial Associative Odor Learning in Neonatal Mice

One-Trial Associative Odor Learning in Neonatal Mice

Early Learning Capability in Rodents: A Review (<em>Rattus Norvegicus and Mus Musculus</em>)

Conditioned taste aversion and traditional learning

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