Oestrogen receptor alpha, growth hormone receptor, and developmental defect of enamel

Arid, Juliana; Oliveira, Daniela Barroso de; Evangelista, S.; Vasconcelos, Katia Regina Felizardo; Dutra, André Luiz Tannus; Oliveira, Sara; Queiroz, Alexandra Mussolino de; Filho, Paulo Nelson; Vieira, Alexandre R.; Küchler, Érika Calvano

doi:10.1111/ipd.12434

Cited by 22 publications

(23 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is also possible that tooth size differences among genotypes observed in the present study are mainly due to the effect of oestrogen and its receptors in the enamel. Other studies also supported that oestrogen and its receptors play an important role in enamel development (Arid et al, 2019; Ferrer et al, 2005; Jedeon et al, 2016; Takeshita et al, 2004). Takeshita et al (2004) reported that enamel microhardness is significantly reduced in an animal model as a result of oestrogen deficiency, due to the fact that oestrogen has an important role in influencing the process of enamel and dentin mineralisation.…”

Section: Discussionmentioning

confidence: 73%

“…Recent studies also reported that genetic polymorphisms in oestrogen receptors are involved in developmental enamel alterations. Genetic polymorphisms in ESR1 were associated with dental fluorosis (Dalledone et al, 2019) and with enamel defects (Arid et al, 2019). In the present study, we demonstrated that ESR1 was associated with tooth size of some maxillary and mandibular teeth.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human permanent tooth sizes are associated with genes encoding oestrogen receptors

et al. 2020

View full text Add to dashboard Cite

Objective: To evaluate if genetic polymorphisms in the oestrogen receptor 1 ( ESR1) and oestrogen receptor 2 ( ESR2) genes encoded for oestrogen receptors alpha (ERα) and beta (ERβ) are involved in permanent tooth size. Design: Cross-sectional study. Setting: Orthodontic Clinic at School of Dentistry of Ribeirão Preto, University of São Paulo. Participants: A total of 108 orthodontic patients. Materials and Methods: Pre-treatment orthodontic records were evaluated. Dental casts were used to determine the maximum crown measurements of fully erupted permanent teeth in the mesiodistal dimensions. Second and third molars were not included in the analysis. Genomic DNA samples were used for the genotyping of four genetic polymorphisms: ESR1 (rs9340799 and rs2234693) and ESR2 (rs1256049 and rs4986938). The associations between tooth size and sex were evaluated using t test. The associations between tooth size and genotype were analysed with linear regression and adjusted by sex at an alpha of P⩽0.05. Results: Female patients presented smaller tooth size than male patients. A statistically significant difference was observed in almost all teeth ( P<0.05). The genetic polymorphisms in rs9340799, rs2234693, rs1256049 and rs4986938 were associated with some tooth sizes in both the maxilla and mandible ( P<0.05). Conclusion: This study provides evidence that genetic polymorphisms in ESR1 and ESR2 could be associated with tooth size in permanent teeth.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Human permanent tooth sizes are associated with genes encoding oestrogen receptors

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this context, the association between variants of the GHR coding gene and craniofacial tissue phenotypes has been exhaustively addressed [ 4 ]. However, since 2013, new GHR variants, such as P561T, rs6184 SNP and rs6180, have been identified as associated, in one hand, with the face mandibular morphology and tooth dimensions [ 2 , 9 , 86 ] and, in the other hand, with developmental defects of enamel [ 12 ]. Recently Marañón-Vásquez et al showed that genetic polymorphisms in GHR (rs2973015) and IGF2R (rs2277071) have been associated with variations in craniofacial dimensions [ 87 ].…”

Section: Gh/igf Axis Modulates the Morphology Of The Dento-alveolar Complex And Cranio-facial Bonesmentioning

confidence: 99%

“…Recent studies have shown that GHR variants (rs6184 and rs6180) are associated with specific tooth and root dimensions [ 9 , 10 ], as well as with mandibular morphology [ 11 ]. Genetic polymorphisms in GHR (rs1509460) are also associated with developmental defects of enamel arguing for the GHR contribution to dental enamel synthesis and structure [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Koffi

Doublier

Ricort

et al. 2021

Cells

View full text Add to dashboard Cite

The GH/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH/IGF axis has also major pleiotropic endocrine and autocrine/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium). The present review re-examines and refines the expression of the elements of the GH/IGF axis in oral tissues and their in vivo and in vitro mechanisms of action in different mineralizing cell types of the dento-alveolar complex including ameloblasts, odontoblasts, pulp cells, cementoblasts, periodontal ligament cells, and jaw osteoblasts focusing on cell-specific activities. Together, these data emphasize the determinant role of the GH/IGF axis in physiological and pathological development, morphometry, and aging of the teeth, the periodontium, and oral bones in humans, rodents, and other vertebrates. These advancements in oral biology have elicited an enormous interest among investigators to translate the fundamental discoveries on the GH/IGF axis into innovative strategies for targeted oral tissue therapies with local treatments, associated or not with materials, for orthodontics and the repair and regeneration of the dento-alveolar complex and oral bones.

show abstract

“…Additionally, the importance of ERs on cortical and trabecular bone, and also in different bone cell types have been widely explored (42). Although the studied genetic polymorphism rs2234693 and rs9340799 in ESR1 and rs1256049 and rs4986938 were not associated with PAP in the present study, they were previously associated with many different bone conditions (28,43) and oral conditions (43)(44)(45). The genetic polymorphisms rs2234693 and rs9340799 in ESR1 have been largely studied.…”

Section: Discussionmentioning

confidence: 62%

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

et al. 2020

View full text Add to dashboard Cite

This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. We included 162 patients who completed endodontic treatment at least one year ago and presented apical periodontitis at the beginning of the root canal therapy. Clinical and radiographic exams were performed to evaluate the presence of PAP or healthy periradicular tissues (healed). Saliva samples were collected as a genomic DNA. The genotyping of ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938), VDR (rs739837 and rs2228570) and miRNA17 (rs4284505) were performed by real-time PCR. Chi-square test was used to the distribution of genotype and allele frequencies. Haplotype analysis was also performed. Eighty-nine patients were included in the “healed” group and 73 in the “PAP” group. No association was found between the allelic and genotypic polymorphisms studied and PAP (p>0.05). Haplotype analysis also did not demonstrated an association (p>0.05). In conclusion, the genetic polymorphisms in ESR1, ESR2, VDR and miRNA17 are not associated with PAP.

show abstract

Oestrogen receptor alpha, growth hormone receptor, and developmental defect of enamel

Cited by 22 publications

References 26 publications

Human permanent tooth sizes are associated with genes encoding oestrogen receptors

Human permanent tooth sizes are associated with genes encoding oestrogen receptors

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

Contact Info

Product

Resources

About