Of all the nerve! A subcutaneous forelimb mass on a cat

Tremblay, Nathalie; Lanevschi, Anne; Doré, Monique; Lanthier, Isabelle; Desnoyers, Michel

doi:10.1111/j.1939-165x.2005.tb00073.x

Cited by 23 publications

(23 citation statements)

References 10 publications

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“…There have been reports on malignant peripheral nerve sheath tumors in the cranial, inguinal, and subcutaneous regions and under the skin of thoracic limbs [14,16,19]. We observed the tumor arising from the spinal canal at surgery.…”

Section: )mentioning

confidence: 80%

Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

et al. 2007

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Comprehensive Veterinary Clinical Studies,4) Veterinary Pathology, 5) Veterinary Physiology and 6) Preventive Veterinary Medicine and Animal Health, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan (Received 17 August 2006/Accepted 22 February 2007 ABSTRACT. A 10-year-old female mongrel cat with back pain was brought to the Nihon University Animal Medical Center. Palpation demonstrated a mass in the back region. Radiography revealed partial destruction of the processus spinosus and the arch of the T8 and T9 vertebrae. On magnetic resonance imaging, the mass was found to have compressed the spinal cord and extended to the outside of the spinal canal. We performed extirpation of the mass, and confirmed that it arose from the spinal canal. Histopathologically, the mass was a malignant peripheral nerve sheath tumor. KEY WORDS: feline, malignant peripheral nerve sheath tumor, MRI.J. Vet. Med. Sci. 69(6): 683-686, 2007 There is considerable confusion concerning the nomenclature of tumors deriving from the peripheral nerve sheath. Histologically, such tumors are classified into categories of benign peripheral nerve sheath tumors (schwannoma and neurofibroma) and malignant peripheral nerve sheath tumors (malignant schwannoma and neurofibrosarcoma) [8].There have been relatively few studies on feline peripheral nerve sheath tumors arising from the spinal canal, and malignant cases of this tumor are even rarer [1,8,9,19]. We encountered a cat with a malignant peripheral nerve sheath tumor arising from the spinal canal. We evaluated the clinical signs, radiography and magnetic resonance imaging (MRI) findings, surgery, and postoperative course.A 10-year-old female mongrel cat, weighing 2.14 kg, with back pain was brought to the Nihon University Animal Medical Center. The cat had been unhealthy with anorexia and constipation for 1 month, and was taken to a local veterinarian. The cat had suffered from back pain for 1 week. A mass was detected in the region of the back, and the cat was referred to our hospital for diagnosis and treatment.On initial examination, the body temperature was 40.3°C, and the heart and respiratory rates were 212/min and 40/ min, respectively. Hematological examination demonstrated slight increases in liver enzyme levels (alanine aminotransferase, 156 U/L; aspartate aminotransferase, 116 U/ L). Neurologically, the cat could walk, and all postural reactions were within the normal ranges. Spinal reflexes and deep pain were normal in both the thoracic and pelvic limbs. The cranial nerves were normal. Radiography revealed partial destruction of the T8 vertebral processus spinosus on the caudal side, T9 vertebral processus spinosus on the cranial side and T9 vertebral arch, between which hyperlucency was observed (Fig. 1).MRI (FlexArt, Toshiba, Tokyo, 1.5T) demonstrated a mass, measuring about 2.5-3 cm, on the back of the T8-9 vertebrae. T1-weighted imaging (TR=500 msec, TE=15 msec, FA 90°, NAQ 1) of the mas...

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confidence: 80%

Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

et al. 2007

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“…The immunohistochemical results support the histologic diagnosis of PNST, that is, all the tumors were S-100 protein positive and muscle-specific actin negative and most (44 of 59) were GFAP positive. Of the previously published cases of feline PNSTs in which immunohistochemistry was performed, 5,11,17,19,20 12 of 12 were vimentin positive, 13 of 14 were S-100 protein positive, 2 of 7 were GFAP positive, and 7 of 7 were negative for smooth muscle actin. Although feline PNSTs have some features seen in schwannomas, neurofibromas, and MPNSTs, they do not fit well into the subcategories used in human medicine.…”

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confidence: 99%

Feline Peripheral Nerve Sheath Tumors

et al. 2009

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Abstract. Feline peripheral nerve sheath tumors are uncommonly reported, and their clinical behavior has not been well documented. Fifty-nine peripheral nerve sheath tumors were collected from 53 cats. All of the tumors involved skin, subcutis, skeletal muscle, and/or mucous membranes. Histologically, the tumors were composed of compact to loosely arranged streams and fascicles of spindled cells with eosinophilic, often wavy cytoplasmic processes; small to occasionally moderate amounts of collagenous to myxoid matrix; and nuclear palisading. Immunohistochemically, all tumors were positive for vimentin and S-100 protein, 44 of 59 were positive for glial fibrillary acidic protein (GFAP), and all were negative for muscle specific actin. The tumors fell into 3 histologic categories: 34 benign tumors with Antoni A areas that were S-100 protein and GFAP positive, 9 benign tumors that lacked Antoni A areas and were S-100 protein positive and GFAP negative, and 16 tumors with features of malignancy. Seventy-five percent of these cases involved the head, neck, or limbs. Recurrent tumors were submitted or tumors were reported to have recurred in 9 cases. Tumor recurrence was reported for all 3 of the histologic subtypes. None was documented as having metastasized.

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“…A mass with similar histological appearance and immunohistochemical results has been described in a domestic cat. 15 Other tumors such as malignant lymphoma, leiomyosarcoma, rhabdomyosarcoma, hemangiosarcoma, malignant melanoma, or an epithelial malignant neoplasm were excluded by a lack of staining for CD3, CD79a, desmin, a-smooth muscle actin, factor VIII-related antigen, pancytokeratin, and melan A. Because the definitive diagnosis of malignant PNST requires more extensive laboratory testing, it might be that the occurrence of malignant PNST is more common in felids than currently thought.…”

Section: Polyglactin 910mentioning

confidence: 99%

“…6,10,[13][14][15][16] The true incidence of PNST in large felids is unknown, with a single report of a schwannoma in the larynx of a lion. 12 The World Health Organization classification of tumors of the nervous system and mesenchymal tumors of the skin and soft tissues in domestic animals combines malignant and benign forms of neurofibroma and schwannoma under the title PNST.…”

Section: Polyglactin 910mentioning

confidence: 99%

Clinical Course of a Malignant Peripheral Nerve Sheath Tumor in a Siberian Tiger (Panthera Tigris Altaica)

et al. 2010

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Abstract. A 14-year-old male Siberian tiger (Panthera tigris altaica) was admitted with an ulcerating mass on the right thoracic wall. Radiographic and computed tomographic evaluation indicated 2 isolated cutaneous masses without any signs of metastasis. Histology of a Tru-Cut biopsy revealed an anaplastic sarcoma with giant cells. Both tumors were resected with appropriate normal tissue margins. The size of the defect did not allow primary closure of the wound; therefore, a mesh expansion technique was attempted. Three months later, the tiger had to be euthanized due to extensive metastasis to the lungs. Histomorphological features and immunohistochemical results confirmed the diagnosis of malignant peripheral nerve sheath tumor. In contrast to domestic animal experience, the tumor had spread extensively to the lungs without local reccurrence in a short period of time. Correct diagnosis requires various immunohistochemical evaluations of the tumor tissue.

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Of all the nerve! A subcutaneous forelimb mass on a cat

Cited by 23 publications

References 10 publications

Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

Feline Peripheral Nerve Sheath Tumors

Clinical Course of a Malignant Peripheral Nerve Sheath Tumor in a Siberian Tiger (Panthera Tigris Altaica)

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