Ohrmißbildung, Facialis- und Abducenslähmung als Syndrom der Thalidomidschädigung

Ectopic bone formation as a complication of surgical rehabilitation in patients with Moebius’ syndrome

“…Indeed, MS and MS like symptoms can be caused by the treatment with potentially teratogenic drugs during pregnancy (e.g. thalidomide and misoprostol), which are known to influence the Hox gene dependent patterning during embryogenesis (Mielke and Parsch, 1963;Elsahy, 1973;Tabin, 1998;Wolpert, 1999;Holmes, 2002;da Silva Dal Pizzol, et al, 2006). There are further hints for a possible involvment of Hox gene-dependent processes in the pathogenesis of MS from comparable disorders and animal models.…”

Hemifacial microsomia, ipsilateral facial palsy, and malformed auricle in two families: An autosomal dominant malformation

“…HM, often combined with facial palsy, was seen commonly in the thalidomide syndrome [Miehlke and Partsch, 1963;Smithells and Leck, 1963;Kleinsasser and Schlothane, 19641. Most cases are sporadic [Gorlin et al, 1976;Thomas, 19801; however, familial cases have been reported [Rollnick and Kaye, 19831.…”

What can we learn from the thalidomide experience

“…In addition to limb anomalies, many other structural and functional anomalies were reported [1,8–11]. Ocular motility dysfunction and structural eye malformations, along with craniofacial anomalies, were prominent [12–20]. Within a few months of the initially reported cases, the drug was withdrawn from commercial sale in most European countries, but not before approximately 5000 cases of malformed live births occurred worldwide.…”

“…It is quite rapidly hydrolyzed and because of this short action time, extreme potency, and the large number of women who took thalidomide, informative histories could be ascertained [20]. Many women knew the exact date of intake and the number of pills they took, and a correlation between time of drug intake and resultant malformations could be made [8,9,12,15,21]. From this information, summary timetables of the causation of various malformations were developed (Fig.…”