Oleic Acid Rich Diet Protects Against the Oxidative Modification of High Density Lipoprotein

Solà, Rosa; Ville, A.E. La; Richard, J.-L.; Motta, Claude; Bargalló, M.Teresa; Girona, Josefa; Masana, Luís; Jacotot, B.

doi:10.1016/s0891-5849(96)00490-x

Cited by 70 publications

(61 citation statements)

References 39 publications

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“…Therefore, some particular attention was given to the liver's fatty acid composition in rats used in the current experiment. In healthy humans, the short-term consumption of olive oil decreased serum oxidative stress (Weinbrenner et al, 2004) and their isolated lipoprotein fractions; LDL and HDL were shown to be enriched with oleic acid and resistant to oxidation (Aviram et al, 1993;Sola et al, 1997). Moreover, PUFAs are more susceptible to peroxidation resulting in MDA formation in mammalian tissues.…”

Section: Discussionmentioning

confidence: 99%

EFFECT OF VIRGIN OLIVE OIL (<i>OLEA EUROPEA</i>. L) ON KIDNEY FUNCTION IMPAIRMENT AND OXIDATIVE STRESS INDUCED BY MERCURIC CHLORIDE IN RATS

Necib¹

2013

American Journal of Biochemistry and Biotechnology

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The study was designed to investigate the possible protective role of virgin olive oil in mercuric chloride induced renal stress, by using biochemical approaches. The effects of virgin olive oil on mercuric chloride induced oxidative and renal stress were evaluated by serum creatinine, urea and uric acid levels, kidney tissue lipid peroxidation, GSH levels, GSH-Px and GST activities. Administration of mercuric chloride induced significant increase in serum: interleukine1, interleukine6 and Tumor Necrosis Factor α (TNFα) levels, creatinine, urea and uric acid concentration showing renal stress. Mercuric chloride also induced oxidative stress, as indicate by decreased kidney tissue of GSH level, GSH-Px and GST activities along with increase the level of lipid peroxidation. Furthermore, treatment with mercuric chloride caused a marked elevation of kidney weight and decreased body weight. Virgin olive oil treatment markedly reduced elevated serum: IL1, IL6, TNFα, creatinine, urea and uric acid levels and conteracted the deterious effects of mercuric chloride on oxidative stress markers changes caused by HgCl 2 in kidney. Our results indicate that virgin olive oil could have a beneficial role against mercuric chloride induced oxidative and renal stress in rat.

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Section: Discussionmentioning

confidence: 99%

EFFECT OF VIRGIN OLIVE OIL (<i>OLEA EUROPEA</i>. L) ON KIDNEY FUNCTION IMPAIRMENT AND OXIDATIVE STRESS INDUCED BY MERCURIC CHLORIDE IN RATS

Necib¹

2013

American Journal of Biochemistry and Biotechnology

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“…Our assay, which used a dilution of whole serum and an incubation time of 4 h, is much closer to physiologic conditions. The same group used monocyte-derived macrophages and fibroblasts to compare the effect of a linoleic acid-rich diet with another diet enriched in oleic oil, without finding any differences in fluidity, size, or the cholesterol efflux capacity of the HDL 3 obtained after both diets (31) In our results, the modifications in the cholesterol efflux capacity were not correlated with the modifications produced in HDL lipid concentrations but rather with the changes observed in some lipoprotein particle concentrations: Lp A-I and Lp A-I/Lp A-I:A-II. Our results suggest that a diet with an adequate ratio of monounsaturated (oleic acid) and polyunsaturated (especially fish oil) fatty acids and a low proportion of saturated fats is hemodynamically healthiest, producing a significant decrease in atherogenic lipoprotein particles.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, several studies have confirmed that the concentration of Lp A-I and Lp A-I:AII particles changes when the fatty acid composition of the diet is modified (28,29). On the other hand, the results of several studies of the effect of dietary fatty acid composition on serum capacity to promote cellular cholesterol efflux are still controversial (30)(31)(32)(33).In the present study, a long-term diet rich in vegetables, fruit, fish, and oils was administered to a healthy population. Different diets were created by varying the fatty acid saturation grade to study the effect on the plasma lipid and lipoprotein particle profile.…”

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confidence: 99%

“…Furthermore, in the women, the sera obtained after the consumption of diets with a high nϪ6 PUFA content also showed significantly more cholesterol efflux than did sera drawn during the SFA and MUFA phases. Although several studies (30)(31)(32)(33)48) recently investigated the effect of dietary fat type on cholesterol efflux, the results do not agree, and this important issue remains to be clarified.Gillotte et al (32) performed a detailed study in primates of the possible effects of diets differing in degree of saturation. They concluded that all diets produce HDL of the same fluidity and size with an identical capacity to promote cellular cholesterol efflux.…”

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confidence: 99%

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Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity

Montoya

Porres

Serrano

et al. 2002

The American Journal of Clinical Nutrition

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Background:The fatty acid content and saturation degree of the diet can modulate HDL composition and cholesterol efflux. Objective: We studied the modifications in plasma lipoprotein particles and serum capacity to stimulate cholesterol efflux induced by different fatty acids. Design: Seventeen women and 24 men followed in the same sequence 4 diets containing 35% of total energy as fat. The saturated fat diet contained 17% palm oil; the monounsaturated fat diet, 20.9% olive oil; the nϪ6 polyunsaturated fat diet, 12.5% sunflower oil; and the nϪ3 polyunsaturated fat diet, sunflower oil supplemented with 4-4.5 g fish oil/d. Each phase lasted 4-5 wk. Results: In both sexes, apolipoprotein (apo) A-I concentrations were significantly lower with unsaturated fat diets than with the saturated fat diet, but concentrations of lipoproteins containing only apo A-I (Lp A-I) were lower only in the men. Concentrations of lipoproteins containing both apo A-I and apo A-II (Lp A-I:A-II) were lower with both polyunsaturated fat diets in the women but significantly higher in the men. Lp E concentrations were significantly higher with the 2 polyunsaturated fat diets. Lp E non-B particle concentrations were not modified in the men but were significantly higher in the women in both polyunsaturated fat phases. Lp C-III concentrations were higher with the saturated fat diet only in the men. The serum samples taken after the nϪ3 polyunsaturated fat phase were the most efficient for extracting cellular cholesterol in both sexes. Conclusions: The monounsaturated and polyunsaturated fat diets were healthier, producing a better lipid profile. The nϪ3 polyunsaturated fat diet increased the capacity of serum to promote the efflux of cholesterol from cells in culture.Am J Clin Nutr 2002;75:484-91. KEY WORDSDiet, fatty acid, lipid, lipoprotein particle, cholesterol efflux, reverse cholesterol transport, HDL, LDL, saturated fat, polyunsaturated fat, monounsaturated fat INTRODUCTIONThe incidence of cardiovascular disease (CVD), the main cause of death and morbidity in developed countries (1), is closely related to diet, mainly to fat composition. The type of fat in the diet can modify the lipid profile, which is directly related to the growth of atheroma plaque (2, 3). In Spain, the mortality rate due to this disease is relatively low compared with that in other developed countries (4,5). This finding could be explained by 2 facts: the Spanish diet is rich in vegetables, fruit, fish, and oils containing monounsaturated fatty acids (MUFAs), a regimen considered favorable for cardiovascular health (6), and Spaniards have elevated plasma concentrations of HDL (7).However, in the dietetic studies performed until now, the results regarding changes in HDL with the administration of monounsaturated fats are controversial (2,8,9). Several epidemiologic studies showed an inverse correlation between serum concentrations of HDL cholesterol and the risk of CVD (10). This favorable role of HDL is mainly due to its participation in metabolic reverse cho...

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“…According to the previous investigations on antioxidant effect of monounsaturated fatty acids (MUFAs), it has been reported that HDL rich in oleic acid was less susceptible to oxidation (18) and the oral administration of oleic acid in adult rats could prevent oxidative stress in liver through inhibiting lipid peroxidation and improving enzyme activities (19). Also, some earlier studies have reported the beneficial effects of n-3 and n-6 polyunsaturated fatty acids on oxidative stress and antioxidant capacity (20,21).…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant Activity of Palmitoleic Acid on the Oxidative Stress Parameters of Palmitic Acid in Adult Rat Cardiomyocytes

Hashem

Khodadadi

Asadi

et al. 2016

Ann Mil Health Sci Res

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Objectives: Many researches have focused on reducing the deleterious effects of oxidative stress in biological systems. The present study investigated the effect of palmitoleic acid on the oxidative stress parameters induced by palmitic acid on cardiomyocytes. Methods:Rat cardiomyocytes were treated with 0.5 mM palmitate, palmitoleate, and palmitate + palmitoleate, or remained as control. Total antioxidant capacity (TAC) and Malondialdehyde (MDA) values were measured in both the cells and the media at 24h and 48h intervals.Results: While cellular TAC values decreased in the palmitic acid group compared to the control group (24%) at 48h time point (P < 0.001), the palmitoleic acid group showed 45% and 19% increases (P ≤ 0.001); Co-incubation of palmitoleate and palmitate indicated 44% (P = 0.001) and 11% (P = 0.02) increases compared to the control group at 24h and 48h time points, respectively. Co-incubation of palmitoleate and palmitate tended to decrease the MDA values in the cells and media compared to the palmitate group at 24h time point (P = 0.09). Conclusions:In conclusion, the harmful effects of the oxidative stress induced by palmitate would be diminished by palmitoleate in the rat cardiomyocytes.

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Oleic Acid Rich Diet Protects Against the Oxidative Modification of High Density Lipoprotein

Cited by 70 publications

References 39 publications

EFFECT OF VIRGIN OLIVE OIL (<i>OLEA EUROPEA</i>. L) ON KIDNEY FUNCTION IMPAIRMENT AND OXIDATIVE STRESS INDUCED BY MERCURIC CHLORIDE IN RATS

EFFECT OF VIRGIN OLIVE OIL (<i>OLEA EUROPEA</i>. L) ON KIDNEY FUNCTION IMPAIRMENT AND OXIDATIVE STRESS INDUCED BY MERCURIC CHLORIDE IN RATS

Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity

The Antioxidant Activity of Palmitoleic Acid on the Oxidative Stress Parameters of Palmitic Acid in Adult Rat Cardiomyocytes

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