Olfactory Dysfunction in Neurodegenerative Diseases

Özdener, Mehmet Hakan; Rawson, Nancy E.

doi:10.29333/ejgm/82202

Cited by 9 publications

(5 citation statements)

References 108 publications

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“…In addition, lipofuscin granules, swelling organelles, vacuolation, and cytoplasmic condensation with disrupted mitochondria were recorded; apoptosis and necrotic neuronal deaths were also identified [ 54 ]. In our hands, these alterations were associated with olfactory dysfunction [ 55 ].…”

Section: An Animal Model To Assess Systemic Effects Of Air-suspendmentioning

confidence: 99%

Vanadium Inhalation in a Mouse Model for the Understanding of Air‐Suspended Particle Systemic Repercussion

Fortoul

Rodríguez-Lara

González-Villalva

et al. 2011

BioMed Research International

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There is an increased concern about the health effects that air-suspended particles have on human health which have been dissected in animal models. Using CD-1 mouse, we explore the effects that vanadium inhalation produce in different tissues and organs. Our findings support the systemic effects of air pollution. In this paper, we describe our findings in different organs in our conditions and contrast our results with the literature.

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Section: An Animal Model To Assess Systemic Effects Of Air-suspendmentioning

confidence: 99%

Vanadium Inhalation in a Mouse Model for the Understanding of Air‐Suspended Particle Systemic Repercussion

Fortoul

Rodríguez-Lara

González-Villalva

et al. 2011

BioMed Research International

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“…The loss of olfaction is, in fact, often associated with many neurodegenerative conditions, such as Parkinson’s (PD) and Alzheimer’s (AD) diseases [1,2]. A decrease in olfactory function could be an early alarm warning for such conditions, since its onset occurs prior to the first clinical signs of pathology by 4–5 years.…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor (Val66Met) polymorphism and olfactory ability in young adults

et al. 2013

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BackgroundBrain- derived neurotrophic factor (BDNF) is linked to neurodegenerative diseases (e.g. Alzheimer disease and Parkinson disease) which are often characterized by olfactory impairment. A specific single nucleotide polymorphism of the BDNF gene, the Val66Met, modulates intracellular trafficking and activity-dependent secretion of BDNF protein. The aim of this study was to investigate a possible association between brain- derived neurotrophic factor Val66Met polymorphism and olfactory function, a well-known biomarker for neurodegeneration, in healthy young adults. A total of 101 subjects (45 males, age 38.7 ± 9.4 years) were assessed using the Sniffin’ Sticks Extended Test, a highly reliable commercial olfactory test composed of three sub-parts, calculating olfactory threshold (sensitivity), odor discrimination and odor identification. The Val66Met polymorphism was determined by polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) analysis.ResultsAn impaired function in Met carriers was found, especially when compared to subjects with Val/Val genotype, in the threshold (5.5 ± 2.0 vs 6.5 ± 1.8, p = 0.009), discrimination (10.3± 2.5 vs 11.9 ± 2.2, p = 0.002), and identification task (13.3 ± 1.6 vs 14.1 ± 1.3, p = 0.007), as well as in the overall TDI Score (29.1 ± 4.5 vs 32.6 ± 3.9, p < 0.001).ConclusionsThese findings appear to have implications for the evaluation of olfactory function and the relation of its impairment to cognitive decline and neurodegenerative disease.

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“…The unique ability of the olfactory system to regenerate throughout the adult life span has also made it a useful model for the study of processes related to neurogenesis (Calof et al, , ) as well as a system for in vitro studies of neuronal structure and function (Vannelli et al, ; Vawter et al, ). Characterization of the structural and functional features of human olfactory neurons in vitro and in vivo has shown that these cells possess many of the features typical of neurons in the central nervous system, allowing for their use as a model system for both normal human neurobiology and neural dysfunctions associated with aging and other neurodegenerative disorders (Rawson and Gomez, ; Ozedner and Rawson, ; Zhang et al, ; Matigian et al, ; Mackay‐Sim, ).…”

mentioning

confidence: 99%

Time course of structural and functional maturation of human olfactory epithelial cells in vitro

Yazinski

Gomez

2013

J of Neuroscience Research

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The unique ability of olfactory neurons to regenerate in vitro has allowed their use for the study of olfactory function, regeneration, and neurodegenerative disorders; thus, characterization of their properties is important. This present study attempts to establish the timeline of structural (protein expression) and functional (odorant sensitivity) maturation of human olfactory epithelial cells (hOE) in vitro using biopsy-derived cultured tissue. Cells were grown for 7 days; on each day, cells were tested for odorant sensitivity using calcium imaging techniques and then protein expression of each cell was tested using immunocytochemistry for proteins typically used for characterizing olfactory cells. Previous studies have shown that mature olfactory neurons in vitro attain a unique "phase-bright" morphology and express the olfactory marker protein (OMP). By day 3 in vitro, a variety of cells were odorant-sensitive, including both "phase-bright" and "phase-dark" cells that have previously been considered glial-like cells. The functional maturation of these hOEs appears to take place within 4 days. Interestingly, the emergence of an odorant sensitivity profile of both phase-bright and phase-dark cells preceded the expression of marker protein expression for OMP (which is expressed only by mature neurons in vivo). This structural maturation took 5 days, suggesting that the development of odorant sensitivity is not coincident with the expression of marker molecules that are hallmarks of structural maturation. These results have important implications for the use of hOEs as in vitro models of olfactory and neuronal function.

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Olfactory Dysfunction in Neurodegenerative Diseases

Cited by 9 publications

References 108 publications

Vanadium Inhalation in a Mouse Model for the Understanding of Air‐Suspended Particle Systemic Repercussion

Vanadium Inhalation in a Mouse Model for the Understanding of Air‐Suspended Particle Systemic Repercussion

Brain-derived neurotrophic factor (Val66Met) polymorphism and olfactory ability in young adults

Time course of structural and functional maturation of human olfactory epithelial cells in vitro

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