Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats

Shen, Jiao; Niijima, Akira; Tanida, Mamoru; Horii, Yuko; Maeda, Keisuke; Nonomura, Katsuya

doi:10.1016/j.neulet.2005.01.058

Cited by 112 publications

(95 citation statements)

References 7 publications

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“…There have been several studies measuring the changes in the firing rate of sympathetic nerves innervating WAT, all by Niijima and associates (83)(84)(85)(86)(87)(88)(89)(90), showing that a number of stimuli increase sympathetic drive to WAT, including odors, tastes, histamine, leptin, and other factors. This relative paucity of electrophysiological measures of sympathetic nerves to WAT contrasts with that for BAT (for reviews, see Refs.…”

Section: Differential Sympathetic Outflow To Peripheral Tissues Inclumentioning

confidence: 99%

Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue

Bartness

Song

2007

Journal of Lipid Research

182

142

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During our study of the reversal of seasonal obesity in Siberian hamsters, we found an interaction between receptors for the pineal hormone melatonin and the sympathetic nervous system (SNS) outflow from brain to white adipose tissue (WAT). This ultimately led us and others to conclude that the SNS innervation of WAT is the primary initiator of lipid mobilization in these as well as other animals, including humans. There is strong neurochemical (norepinephrine turnover), neuroanatomical (viral tract tracing), and functional (sympathetic denervation-induced blockade of lipolysis) evidence for the role of the SNS in lipid mobilization. Recent findings suggest the presence of WAT sensory innervation based on strong neuroanatomical (viral tract tracing, immunohistochemical markers of sensory nerves) and suggestive functional (capsaicin sensory denervation-induced WAT growth) evidence, the latter implying a role in conveying adiposity information to the brain. By contrast, parasympathetic nervous system innervation of WAT is characterized by largely negative neuroanatomical evidence (viral tract tracing, immunohistochemical and biochemical markers of parasympathetic nerves). Functional evidence (intraneural stimulation and in situ microdialysis) for the role of the SNS innervation in lipid mobilization in human WAT is convincing, with some controversy regarding the level of sympathetic nerve activity in human obesity.-Bartness, T. J., and C. K. Song. Sympathetic and sensory innervation of white adipose tissue. J. Lipid Res. 2007. 48: 1655-1672. Supplementary key words obesityObesity is a disease of literally and figuratively enormous proportions (1, 2) and is an independent risk factor for type II diabetes, cardiovascular disease, stroke, and some cancers (3-5). Estimates of the mortality rate of overweight/obese individuals range from ?325,000 deaths per year (6) to as low as ?26,000 (7), making overweight/ obesity either the number two or number seven cause of death in adults in the United States, respectively. Considerable research effort has focused on determining the factors involved in the development of obesity in nonhuman animals; consequently, our understanding of these is substantial, but still far from complete. Somewhat surprisingly, less effort has focused on determining the factors involved in the reversal of obesity in nonhuman animals. We have contributed to these latter efforts by studying the reversal of a naturally occurring seasonal obesity in Siberian hamsters (Phodopus sungorus). In the process of conducting this work, we discovered the importance of the sympathetic nervous system (SNS) in lipid mobilization from white adipose tissue (WAT) as well as more recently realizing the possible importance of the sensory innervation of WAT. Several overviews of the role of the SNS in lipid mobilization were published recently (8-11). To give a better understanding of how we came to the realization that lipid mobilization occurs primarily through the sympathetic innervation of WAT, we will descri...

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Section: Differential Sympathetic Outflow To Peripheral Tissues Inclumentioning

confidence: 99%

Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue

Bartness

Song

2007

Journal of Lipid Research

182

142

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“…Treatment with either ZnSO 4 (used for treatment of anosmia) or intraperitoneal or intracranial injection of diphenhydramine (a histamine H1 receptor-antagonist) abolished the SGFO-or scent of limonene-mediated increases in plasma glycerol, sympathetic renal efferent (SRE) nerve activity and BP, as well as the decrease in VGE activity in rats. 5,6) Furthermore, a 15-min exposure to the SGFO or the scent of limonene three times a week reduced food intake and body weight. 5,6) Interestingly, bilateral lesions of the SCN eliminated these SGFO-and limonene-mediated effects.…”

Section: Olfactory Stimuli Regulate Autonomic Nervous System Activitymentioning

confidence: 97%

“…5,6) Furthermore, a 15-min exposure to the SGFO or the scent of limonene three times a week reduced food intake and body weight. 5,6) Interestingly, bilateral lesions of the SCN eliminated these SGFO-and limonene-mediated effects. 6) In fact, studies that utilized the pseudorabies virus, which is trans-ported into the brain in a retrograde and polysynaptic manner, provide evidence that the SCN is a control center for autonomic nerves.…”

Section: Olfactory Stimuli Regulate Autonomic Nervous System Activitymentioning

confidence: 97%

“…One is grapefruit oil, which has excitatory effects, and the other is lavender oil, which has inhibitory effects. Olfactory stimulation with the scent of grapefruit oil (SGFO) or the scent of limonene, a component of grapefruit oil, excited the sympathetic efferent nerve that innervates the white adipose tissue (WAT), the brown adipose tissue (BAT), adrenal gland and kidney and inhibited vagal gastric efferent (VGE) nerve activity in rats [4][5][6] (Fig. 1) and mice.…”

Section: Olfactory Stimuli Regulate Autonomic Nervous System Activitymentioning

confidence: 99%

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Role Played by Afferent Signals from Olfactory, Gustatory and Gastrointestinal Sensors in Regulation of Autonomic Nerve Activity

Kitamura

Torii

Uneyama

et al. 2010

Biological & Pharmaceutical Bulletin

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Afferent signals from the olfactory system, gustatory system and gastrointestinal (GI) tract control visceral functions such as oral and gut secretions and several digestive, endocrine, thermogenic, cardiovascular and renal responses via autonomic reflexes. It is well known that odors and tastes, such as umami, can stimulate oral and GI secretions to improve food intake and digestion in a process termed the cephalic phase response. The perception of GI nutrients, such as carbohydrates and amino acids, can control food digestion, absorption and utilization via the vago-vagal reflex during a meal. Recent advances in understanding the molecular physiology of taste indicate that taste receptors able to sense such nutrients are widely distributed in the GI tract, including the oral cavity. These receptors act as nutrient sensors to trigger food digestion, the release of GI peptides and the formation of food preferences. In this paper, we review recent evidence on the regulation of GI functions by the autonomic nervous system via peripheral odor and nutrient sensors.

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“…August 2016 | Volume 4 | Issue 8 | Page 422 dan et al, 2003;Mau et al, 2003;El-massry et al, 2006;Mimica-Dukic et al, 2004;Yanishlieva-Maslarova et al, 2001), antimicrobial properties (Hulin et a., 1998;Gutierrez et al, 2008;Bozin et al, 2006;Kelly, 1998;Burt, 2004;O'Gara et al, 2000;Santoyo et al, 2006), antifungal activity (Tripathi et al, 2008;Fisher et al, 2008;Razzaghi-Abyaneh et al, 2009;Davidson and Naidu, 2000;El-Seedi, 2008;Nejad Ebrahimi, 2008;Stefanello et al, 2008;Suhr and Nielsen, 2003;Daferera et al, 2000), antiviral activity (Allahverdiyev et al, 2004;Armaka et al, 1999;Garcia et al, 2003;Edris et al, 2007), anti-inflammatory activity (Schmid-Scheonbein, 2006;Vogler and Ernst, 1999;Chithra et al, 1998;Heggers et al, 1993;Reynolds and Dweck, 1999;Shelton, 1991;Tanaka and Shibamoto, 1999), antimutagenic activity (Ramel, 1986;Odin, 1997;Kada and Shimoi, 1987;De-Oliveira, 1997;Bakkali et al, 2006), anticarcinogenic activity (Trichopoulou et al, 2000;Guba, 2000;Greenwald et al, 2001;Abdalla et al, 2007) of essential oil. Some of the miscellaneous activities like digestive activity (Sandhar et al, 2011;…”

Section: Advances In Animal and Veterinary Sciencesmentioning

confidence: 99%

Gas Chromatography Mass Spectrometric (GCMS) Analysis of Essential Oils of Medicinal Plants

Hassan¹,

Rehman²,

Noreen³

et al. 2016

Adv. Anim. Vet. Sci.

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Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats

Cited by 112 publications

References 7 publications

Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue

Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue

Role Played by Afferent Signals from Olfactory, Gustatory and Gastrointestinal Sensors in Regulation of Autonomic Nerve Activity

Gas Chromatography Mass Spectrometric (GCMS) Analysis of Essential Oils of Medicinal Plants

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