Oligofructose promotes satiety in healthy human: a pilot study

Abstract

Objective: The administration of a fermentable dietary fibre (oligofructose) in rats increases satietogenic gut peptides and lowered spontaneous energy intake. The aim of the study was to assess the relevance of those effects of oligofructose on satiety and energy intake in humans. Design: Single-blinded, crossover, placebo-controlled design, pilot study. Subjects: Volunteers included five men and five women aged 21-39 years, BMI ranging from 18.5 to 27.4 kg/m 2 , were randomly assigned as described below. Interventions: Subjects were included in two 2-week experimental phases during which they received either fibre (oligofructose (OFS)) or placebo (dextrine maltose (DM)); a 2-week washout period was included between crossover phases. In total, 8 g OFS or 8 g DM were ingested twice daily (16 g/day in total). Energy intake, hunger, satiety, fullness and prospective food consumption were assessed with analogue scales at the end of each experimental phase. Results: During breakfast, OFS significantly increases the satiety (P ¼ 0.04) without any difference on other sensations as compared to DM treatment periods. After lunch, no significant differences are observed between treatment period. At dinner, OFS significantly increases satiety (P ¼ 0.04), reduces hunger (P ¼ 0.04) and prospective food consumption (P ¼ 0.05). The energy intake at breakfast and lunch are significantly lower (P ¼ 0.01, 0.03, respectively) after OFS treatment than after DM treatment. Total energy intake per day is 5% lower during OFS than in DM period. Conclusion: Oligofructose treatment increases satiety following breakfast and dinner, reduces hunger and prospective food consumption following dinner. This pilot study presents a rationale to propose oligofructose supplements in the management of food intake in overweight and obese patients. Sponsorship: This project is supported by an FSR grant from the Université catholique de Louvain.

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia

“…This merits further investigation. While the doses used in animal studies are not directly transposable to human nutrition, several reports have demonstrated that ingestion of fructo-oligosaccharides at the dose of 5 to 20 g/day are sufficient to promote prebiotic [37][38][39][40] and physiological effects [41][42][43][44].…”

Type 2 diabetes and gut microbiome: at the intersection of known and unknown

“…It has been demonstrated that fermentation of prebiotics by gut microbiota resulted in reduced hunger and increased satiety, thereby decreasing total energy intake by about 10%. 25,26 Activation of GPR 43 reduces inflammation and stimulates GLP1 and GLP2 release from L cells. 27 Changes in the distribution and localization of Zonula Occludens-1 (ZO-1) and Occludin (2 tight junction proteins) in intestinal tissue are associated with the increased gut permeability occurring in obese and diabetic rodents.…”

The art of targeting gut microbiota for tackling human obesity

“…Prebiotics may exert a satietogenic effect as demonstrated and confirmed in studies with mice in which the effects of acetate on production of appetite suppression were shown, even in absence of increased levels of GLP-1 and PYY (Frost et al 2014). In humans, the satietogenic effects of prebiotics such as oligofructose have also been shown (Cani et al 2006(Cani et al , 2009a.…”