Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats

Çoban, Jale; Öztezcan, Serdar; Doğru‐Abbasoğlu, Semra; Bingül, İlknur; Yesil-Mizrak, Kubra; Uysal, Müjdat

doi:10.1111/ggi.12192

Cited by 39 publications

(22 citation statements)

References 40 publications

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“…Under the present experimental conditions, our data demonstrate that (i) polyphenols can partially protect from ethanol-induced oxidative stress although further studies analyzing multiple methods of oxidative stress are required; (ii) polyphenols by themselves do not appear to potentiate the natural endogenous antioxidant resources following chronic alcohol exposure; (iii) however, polyphenols administration by themselves may potentiate the natural endogenous antioxidant resources in normal conditions. Similar findings were previously observed in aged rats treated with an olive leaf extract [16] showing a decrease in oxidative stress by acting as an antioxidant per se but not affecting the antioxidant system. In this study, we administered a blend of polyphenols containing mostly hydroxytyrosol.…”

Section: Discussionsupporting

confidence: 90%

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Olive polyphenol effects in a mouse model of chronic ethanol addiction

et al. 2017

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Section: Discussionsupporting

confidence: 90%

“…We found that FORT levels in blood serum were significantly higher in EtOH mice as compared to controls. Quite interestingly, the presence of polyphenols seems to have partially counteracted this effect (F [3,16] ¼ 299.95, P < 0.01 in the ANOVA: see Fig. 1A for post-hoc comparisons).…”

Section: Oxidative Stress Evaluationmentioning

confidence: 95%

Olive polyphenol effects in a mouse model of chronic ethanol addiction

et al. 2017

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“…Interestingly, OLE and the main component HT proved to have antioxidant effects [ 43 , 44 , 45 ]. OLE treatment has improved the hepatic GSH level in aged rats [ 46 ]. In our report, OLE treatment ameliorated acrolein-exaggerating myoardial injury may partly result from OLE restoring the level of GSH that bound acrolein, which attenuated ER stress.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Olive Leaf Extract on Acrolein-Exacerbated Myocardial Infarction via an Endoplasmic Reticulum Stress Pathway

Chen

et al. 2018

IJMS

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Many studies reported that air pollution particulate matter (PM) exposure was associated with myocardial infarction (MI). Acrolein representing the unsaturated aldehydes, the main component of PM, derives from the incomplete combustion of wood, plastic, fossil fuels and the main constitute of cigarette smoking. However, the effect of acrolein on MI remains not that clear. In the current study, the effect of acrolein-exacerbated MI was investigated. In vivo, male Sprague–Dawley rats received olive leaf extract (OLE) followed by acrolein, then isoprenaline (ISO) was received by subcutaneous injection to induce MI. Results showed that the expression levels of GRP78 and CHOP, two major components of endoplasmic reticulum (ER) stress were higher in the combination of acrolein and ISO than those in ISO treatment. The apoptosis marker, Bax, was also higher while the anti-apoptosis indicator, Bcl2 expression was lower both at protein and mRNA levels in the combination group. Also, the acrolein-protein adducts and myocardial pathological damage increased in the combination of acrolein and ISO relative to the ISO treatment. Besides, cardiac parameters, ejection fraction (EF) and fractional shortening (FS) were reduced more significantly when acrolein was added than in ISO treatment. Interestingly, all the changes were able to be ameliorated by OLE. Since hydroxytyrosol (HT) and oleuropein (OP) were the main components in OLE, we next investigated the effect of HT and OP on cardiomyocyte H9c2 cell apoptosis induced by acrolein through ER stress and Bax pathway. Results showed that GRP78, CHOP and Bax expression were upregulated, while Bcl2 expression was downregulated both at the protein and mRNA levels, when the H9c2 cells were treated with acrolein. In addition, pretreatment with HT can reverse the expression of GRP78, CHOP, Bax and Bcl2 on the protein and mRNA levels, while there was no effect of OP on the expression of GRP78 and CHOP on the mRNA levels. Overall, all these results demonstrated that OLE and the main components (HT and OP) could prevent the negative effects of acrolein on myocardium and cardiomyocytes.

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“…Indeed, several investigators have found that AGE levels were increased in the serum and tissues of aged animals, and humans erythrocytes and several tissues, such as the liver, heart and brain, have been observed in experimental animals. Increases in oxidative stress parameters have also been detected in humans with aging …”

Section: Introductionmentioning

confidence: 99%

Antiglycation and anti‐oxidant efficiency of carnosine in the plasma and liver of aged rats

Bingül

Yılmaz

Aydın

et al. 2017

Geriatrics Gerontology Int

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Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats

Abstract: The present results suggest that OLE seems to be useful for decreasing oxidative stress in examined tissues by acting as an anti-oxidant itself without affecting the anti-oxidant system.

Cited by 39 publications

References 40 publications

Olive polyphenol effects in a mouse model of chronic ethanol addiction

Olive polyphenol effects in a mouse model of chronic ethanol addiction

Protective Effects of Olive Leaf Extract on Acrolein-Exacerbated Myocardial Infarction via an Endoplasmic Reticulum Stress Pathway

Antiglycation and anti‐oxidant efficiency of carnosine in the plasma and liver of aged rats

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