We introduce differential characters of Drinfeld modules. These are function-field analogues of Buium's p-adic differential characters of elliptic curves and of Manin's differential characters of elliptic curves in differential algebra, both of which have had notable Diophantine applications. We determine the structure of the group of differential characters. This shows the existence of a family of interesting differential modular functions on the moduli of Drinfeld modules. It also leads to a canonical F -crystal equipped with a map to the de Rham cohomology of the Drinfeld module. This F -crystal is of a differential-algebraic nature, and the relation to the classical cohomological realizations is presently not clear.