On-Line Fast Atom Bombardment Mass Spectrometric Detection in High-Speed Countercurrent Chromatography Through a Moving Belt Interface

McGuire, J. H.; Proefke, Mark L.; Conway, Walter D.; Rinehart, Kenneth L.

doi:10.1021/bk-1995-0593.ch012

Cited by 3 publications

(1 citation statement)

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“…Previous work has mostly involved the reduced pressure ionisation techniques such as frit electron ionisation (EI), chemical ionisation (CI), 6 as well as online fast-atom bombardment (FAB). 7 There have been surprisingly few papers on CCC/MS featuring atmospheric pressure ionisation techniques in recent times, and the development of electrospray ionisation (ESI) over the last decade in the field of HPLC/MS means that CCC/MS may be able to take advantage of already developed methodology.…”

Section: Polar Herbicidesmentioning

confidence: 99%

Separation and characterisation of five polar herbicides using countercurrent chromatography with detection by negative ion electrospray ionisation mass spectrometry

Kidwell

Jones

Games

2001

Rapid Comm Mass Spectrometry

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Five polar herbicides were separated and characterised using high-speed analytical countercurrent chromatography (HSACCC) in conjunction with online electrospray mass spectrometry (ESI-MS). The countercurrent chromatography used a standard isocratic biphasic solvent system of hexane/ethyl acetate/methanol/water in reverse phase to effect the separation of these five environmentally important compounds. The chromatograph was coupled to a triple quadrupole mass spectrometer via a standard electrospray liquid chromatography interface that was able to give mass spectra in negative ion mode of each compound. Limits of detection are reported for this series of compounds along with representative negative ion ESI-MS data and calibrations for the separation.

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Section: Polar Herbicidesmentioning

confidence: 99%

Separation and characterisation of five polar herbicides using countercurrent chromatography with detection by negative ion electrospray ionisation mass spectrometry

Kidwell

Jones

Games

2001

Rapid Comm Mass Spectrometry

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New advances in countercurrent chromatography and centrifugal partition chromatography: focus on coupling strategy

2013

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Countercurrent chromatography (CCC) is an attractive separation method because the analytes are partitioned between two immiscible liquid phases avoiding problems related to solid stationary phase. In recent years, this technique has made great progress in separation power and detection potential. This review describes coupling strategies involving high speed CCC (HSCCC) or centrifugal partition chromatography (CPC). It includes on-line extraction-isolation, hyphenation with mass spectrometry (MS) and nuclear magnetic resonance (NMR) detectors, multidimensional CCC (MDCCC), two-dimensional CCC (2D-CCC), on-line coupling with liquid chromatography (LC), and biological tests, and innovative off-line developments. The basic principles of each method are presented and applications are summarized.

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Application of High-Speed Countercurrent Chromatography/Electrospray Ionization Mass Spectrometry (HSCCC/ESIMS) in Natural Products Chemistry

Kong

Rinehart

Milberg

et al. 1998

Journal of Liquid Chromatography & Related Technologies

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In this paper, we describe the technique of analytical highspeed countercurrent chromatography coupled with electrospray ionization mass spectrometry (HSCCCESIMS) for the first time, and evaluate its performance in terms of chromatography and mass spectrometry. This technique demonstrates the capability and resolving power of HSCCC in the separation of a few natural product mixtures and utilizes ESIMS as a detector with continuous detection and high sensitivity. Application of this HSCCC/ESIMS system is illustrated by the separation and detection of biologically important compounds. 65

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On-Line Fast Atom Bombardment Mass Spectrometric Detection in High-Speed Countercurrent Chromatography Through a Moving Belt Interface

Cited by 3 publications

References 0 publications

Separation and characterisation of five polar herbicides using countercurrent chromatography with detection by negative ion electrospray ionisation mass spectrometry

Separation and characterisation of five polar herbicides using countercurrent chromatography with detection by negative ion electrospray ionisation mass spectrometry

New advances in countercurrent chromatography and centrifugal partition chromatography: focus on coupling strategy

Application of High-Speed Countercurrent Chromatography/Electrospray Ionization Mass Spectrometry (HSCCC/ESIMS) in Natural Products Chemistry

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