Key Points
Question
Can deep learning algorithms achieve a performance comparable with that of ophthalmologists on multidimensional identification of retinopathy of prematurity (ROP) using wide-field retinal images?
Findings
In this diagnostic study of 14 108 eyes of 8652 preterm infants, a deep learning–based ROP screening platform could identify retinal images using 5 classifiers, including image quality, stages of ROP, intraocular hemorrhage, preplus/plus disease, and posterior retina. The platform achieved an area under the curve of 0.983 to 0.998, and the referral system achieved an area under the curve of 0.9901 to 0.9956; the platform achieved a Cohen κ of 0.86 to 0.98 compared with 0.93 to 0.98 by the ROP experts.
Meaning
Results suggest that a deep learning platform could identify and classify multidimensional ROP pathological lesions in retinal images with high accuracy and could be suitable for routine ROP screening in general and children’s hospitals.