On-substrate fabrication of a bio-conjugated Au nanoring solution for photothermal therapy application

Tseng, Hung-Yu; Chen, Weifang; Chu, Che-Kuan; Chang, Wen‐Chun; Kuo, Yao‐Haur; Kiang, Yean‐Woei; Yang, Chun‐Chen

doi:10.1088/0957-4484/24/6/065102

Cited by 14 publications

(28 citation statements)

References 37 publications

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“…Au NRIs were fabricated first on a polymer substrate based on the techniques of nano-imprint lithography and ion-bombardment induced Au sputtering in a reactive ion etching process [22,23,24]. Briefly speaking, regularly patterned nanopillars were formed first on a polymer substrate through the processes of nano-imprint and dry etching.…”

Section: Methodsmentioning

confidence: 99%

“…In this spectral range, light can penetrate into tissue the deepest [22,23,24,25]. When Au NRIs taken up by cells are excited by a light source with the wavelength close to its LSP resonance peak, the enhanced absorption can produce a strong PT effect for causing cancer cell damage [22,23,24,25]. By linking a photosensitizer to Au NRIs for cell uptake, i.e., using Au NRIs as the photosensitizer carrier, an illumination to excite the photosensitizer can result in the PD effect.…”

Section: Introductionmentioning

confidence: 99%

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Enhancements of Cancer Cell Damage Efficiencies in Photothermal and Photodynamic Processes through Cell Perforation and Preheating with Surface Plasmon Resonance of Gold Nanoring

Hsiao

et al. 2018

Molecules

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The methods of cell perforation and preheating are used for increasing cell uptake efficiencies of gold nanorings (NRIs), which have the localized surface plasmon resonance wavelength around 1064 nm, and photosensitizer, AlPcS, and hence enhancing the cell damage efficiency through the photothermal (PT) and photodynamic (PD) effects. The perforation and preheating effects are generated by illuminating a defocused 1064-nm femtosecond (fs) laser and a defocused 1064-nm continuous (cw) laser, respectively. Cell damage is produced by illuminating cell samples with a focused 1064-nm cw laser through the PT effect, a focused 1064-nm fs laser through both PT and PD effects, and a focused 660-nm cw laser through the PD effect. Under various conditions with and without cell wash before laser illumination, through either perforation or preheating process, cell uptake and hence cell damage efficiencies can be enhanced. Under our experimental conditions, perforation can be more effective at enhancing cell uptake and damage when compared with preheating.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancements of Cancer Cell Damage Efficiencies in Photothermal and Photodynamic Processes through Cell Perforation and Preheating with Surface Plasmon Resonance of Gold Nanoring

Hsiao

et al. 2018

Molecules

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“…When AuNRIs is not attached to its surface, the transfer rate in the early stage is higher than the PDT effect alone. 67 The way to keep the cells in the early stage of apoptosis for a long time is to incubate the cells with AuNRIs connected with AlPcs, and the light of the 1064-nm laser is reached, resulting in the combined effect of PTT and PDT ( Figure 2).…”

Section: Cell Apoptosismentioning

confidence: 99%

<p>Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles</p>

Hou

Yang

Liu

et al. 2020

IJN

243

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The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on.

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“…The fabrication procedure and the typical LSPR characteristics of the used Au NRIs have been reported in literature [19]. The Au NRIs are first fabricated and surface modified on a substrate and then lifted off in a deionized (DI) water solution.…”

Section: Ample Preparation and Experimental Setupmentioning

confidence: 99%

“…However, the LSPR wavelengths of those Au NPs are usually shorter than 900 nm such that they can be used only for OCT scan around 800 nm in operation wavelength. For deeper OCT scan with an operation wavelength longer than 1000 nm, Au nanoring (NRI) can be used [15,[17][18][19][20]. By controlling the outer diameter, height, and thickness of an NRI, the LSPR wavelength of an NRI can be tuned from 950 through 1350 nm.…”

Section: Introductionmentioning

confidence: 99%

Photothermal Behaviors of Flowing Media Caused by Localized Surface Plasmon Resonance of Au Nanorings

Chi

et al. 2015

Plasmonics

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Based on the scanning of photothermal optical coherence tomography (PT-OCT), the photothermal behavior of a flowing medium generated by the enhanced absorption of localized surface plasmon resonance of incorporated Au nanorings (NRIs) is observed. In particular, the effects of air bubble generation and thermally induced bubble size oscillation in a flowing medium through the incorporation of Au NRIs and modulated laser illumination are demonstrated. The size oscillation of the air bubble produces the vibration of the flowing medium, which is synchronized with the laser modulation, for generating PT-OCT signal. At the resonance frequency of flowing-medium vibration, the PT-OCT signal reaches the maximum level. The resonance frequency is related to the mass density and viscosity of the flowing medium and is independent of the flow speed of the medium in a vessel. Such a relation can be used for in situ monitoring the mass density and viscosity of a flowing medium.

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On-substrate fabrication of a bio-conjugated Au nanoring solution for photothermal therapy application

Cited by 14 publications

References 37 publications

Enhancements of Cancer Cell Damage Efficiencies in Photothermal and Photodynamic Processes through Cell Perforation and Preheating with Surface Plasmon Resonance of Gold Nanoring

Enhancements of Cancer Cell Damage Efficiencies in Photothermal and Photodynamic Processes through Cell Perforation and Preheating with Surface Plasmon Resonance of Gold Nanoring

<p>Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles</p>

Photothermal Behaviors of Flowing Media Caused by Localized Surface Plasmon Resonance of Au Nanorings

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