On The Biology and Immunology of Hodgkin’s Disease

Kaplan, HenryS.

doi:10.1007/978-3-642-67984-1_2

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…Although many studies have been performed on Hodgkin's disease, the origin and nature of Hodgkin (H) and Sternberg-Reed (SR) cells remain obscure (Papadimitriou et al, 1978;Kaplan, 1981;Stein et al, 1981b). The recent availability of the L428 cell line, which was established from the pleural exudate of a patient with Hodgkin's disease (Schaadt et al, 1980), prompted us to prepare a conventional antiserum against these cells (Stein et al, 1981a,b).…”

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“…The presence of granulocytic cell-specific antigens in H and SR cells in most of the cases of Hodgkin's disease suggests that (I) H and SR cells (including the lacunar cell variant) are not heterogeneous, but rather homogeneous in origin and nature, at least in a majority of cases, and (2) H and SR cells are more closely related to cells of the granulocytic cell lineage than to any other type of cell of the hemato-lymphoid system. Although many studies have been performed on Hodgkin's disease, the origin and nature of Hodgkin (H) and Sternberg-Reed (SR) cells remain obscure (Papadimitriou et al, 1978;Kaplan, 1981;Stein et al, 1981b). The recent availability of the L428 cell line, which was established from the pleural exudate of a patient with Hodgkin's disease (Schaadt et al, 1980), prompted us to prepare a conventional antiserum against these cells (Stein et al, 1981a,b).…”

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confidence: 99%

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Hodgkin and sternberg‐reed cells contain antigens specific to late cells of granulopoiesis

Stein¹,

Gerdes²,

Uchańska-Ziegler³

et al. 1982

Intl Journal of Cancer

149

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The results of a recent investigation, in which an antiserum specifically directed against Hodgkin (H) and Sternberg-Reed (SR) cells was prepared, indicated the existence of a granulocytic cell-specific antigen on H and SR cells. In the present study, a large series of biopsies from patients with Hodgkin's disease were subjected to immunostaining with monoclonal mouse antibodies raised against acute myelomonocytic leukemia (AMML) cells. Among seven hybrids that secreted antibodies showing reactivity to AMML cells but not to Daudi cells, there were three (TU5, TU6 and TU9) whose antibodies selectively stained formalin resistant antigens in cells of granulopoiesis. The strongest staining was found in the more mature cells; only a few promyelocytes stained very faintly with TU9, H and SR cells showed distinct staining for TU9 in 57 (76%) of the 75 tested cases of Hodgkin's disease, whereas TU5 and TU6-reactive H and SR cells were found in only 35 cases (47%). All cases of the nodular sclerosis type and almost all cases of the mixed cellularity type contained TU9-reactive H and SR cells, although the percentage varied from case to case. TU9-reactive H and SR cells were demonstrated in nine of 12 cases of the lymphocyte depletion type and in eight of 21 cases of the lymphocyte predominance type. The presence of granulocytic cell-specific antigens in H and SR cells in most of the cases of Hodgkin's disease suggest that (1) H and SR cells (including the lacunar cell variant) are not heterogeneous, but rather homogeneous in origin and nature, at least in a majority of cases, and (2) H and SR cells are more closely related to cells of the granulocytic cell lineage than to any other type of cell of the hemato-lymphoid system.

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confidence: 98%

mentioning

confidence: 99%

Hodgkin and sternberg‐reed cells contain antigens specific to late cells of granulopoiesis

Stein¹,

Gerdes²,

Uchańska-Ziegler³

et al. 1982

Intl Journal of Cancer

149

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“…Combining this evidence with the epidemiologic evidence of potential cancer protection or risk, it is not unreasonable to suspect that these cells play an active role in the carcinogenesis and pathogenesis of these diseases. As early as 1960, maternal lymphocytes were postulated to participate in Hodgkin lymphoma of offspring [16]. Women who are microchimeric in the peripheral blood appear to be at lower risk for the development of breast cancer [17][18][19].…”

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confidence: 99%

Fetal Microchimerism in Cancer Protection and Promotion: Current Understanding in Dogs and the Implications for Human Health

Bryan

2015

AAPS J

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Abstract. Fetal microchimerism is the co-existence of small numbers of cells from genetically distinct individuals living within a mother's body following pregnancy. During pregnancy, bi-directional exchange of cells occurs resulting in maternal microchimerism and even sibling microchimerism in offspring. The presence of fetal microchimerism has been identified with lower frequency in patients with cancers such as breast and lymphoma and with higher frequency in patients with colon cancer and autoimmune diseases. Microchimeric cells have been identified in healing and healed tissues as well as normal and tumor tissues. This has led to the hypothesis that fetal microchimerism may play a protective role in some cancers and may provoke other cancers or autoimmune disease. The long periods of risk for these diseases make it a challenge to prospectively study this phenomenon in human populations. Dogs get similar cancers as humans, share our homes and environmental exposures, and live compressed lifespans, allowing easier prospective study of disease development. This review describes the current state of understanding of fetal microchimerism in humans and dogs and highlights the similarities of the common cancers mammary carcinoma, lymphoma, and colon cancer between the two species. Study of fetal microchimerism in dogs might hold the key to characterization of the type and function of microchimeric cells and their role in health and disease. Such an understanding could then be applied to preventing and treating disease in humans.

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T-lymphocyte subpopulations in B-cell-derived non-hodgkin's lymphomas and hodgkin's disease

Knowles

Halper²,

Jakobiec³

1984

Cancer

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The authors used E‐rosette formation and OKT3 reactivity to determine the percent of T‐cells in lymph nodes involved by B‐cell non‐Hodgkin's lymphomas (B‐NHL) and by Hodgkin's disease (HD). The percent of helper and suppressor/cytotoxic T‐cells was determined by reactivity with OKT4 and OKT8, respectively. T‐cells were also analyzed for two signs of activation: acquisition of Ia antigens and loss of acid a‐naphthyl acetate esterase (ANAE) activity. The results were compared with those of lymph nodes exhibiting benign lymphoid hyperplasia (BLH). The percentage of T‐cells ranged from 50% to 82%, mean 63 ± 13%, in 25 cases of BLH, and from 6% to 62%, mean 23 ± 11%, in 51 cases of B‐NHL. The OKT4/T8 ratio was 1.0 to 6.2, mean 3.4 ± 2.2, in the cases of BLH, and 0.5 to 5.1, mean 2.4 ± 1.3, in the cases of B‐NHL. There was no obvious or significant correlation between the percent of T‐cells or the OKT4/T8 ratio and the surface immunoglobulin isotype expressed by the neoplastic B‐cells, the morphologic category of B‐NHL, or the clinical stage of disease. Activated T‐cells were ≦3% in the cases of BLH and B‐NHL. Fifteen lymph nodes involved by HD contained 44% to 96%, mean 74%, E+ (T) cells. Five of these 15 cases contained a significant number of E−OKT3+ cells suggesting that E‐rosette formation is not always a reliable T‐cell marker in HD. Three other cases contained a large number of E+OKT3− cells. The OKT4/T8 ratio ranged from 0.4 to 21.7, mean 6.7 ± 5.3, in these cases, representing the most significant T‐cell subset imbalances in this series. Large numbers of Ia+E+ and/or E+ ANAE− cells, presumably activated T‐cells, were present in 7 of these 15 cases of HD. These studies demonstrate the wide variation in the percent of T‐cells and in the T‐cell subset distribution in lymph nodes exhibiting benign lymphoid hyperplasia and in lymph nodes involved by B‐cell‐derived non‐Hodgkin's lymphomas and Hodgkin's disease.

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On The Biology and Immunology of Hodgkin’s Disease

Cited by 8 publications

References 47 publications

Hodgkin and sternberg‐reed cells contain antigens specific to late cells of granulopoiesis

Hodgkin and sternberg‐reed cells contain antigens specific to late cells of granulopoiesis

Fetal Microchimerism in Cancer Protection and Promotion: Current Understanding in Dogs and the Implications for Human Health

T-lymphocyte subpopulations in B-cell-derived non-hodgkin's lymphomas and hodgkin's disease

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