On the delay-dependent involvement of the hippocampus in object recognition memory

The Allosteric Potentiation of Nicotinic Acetylcholine Receptors by Galantamine Ameliorates the Cognitive Dysfunction in Beta Amyloid25–35 I.c.v.-Injected Mice: Involvement of Dopaminergic Systems

“…Further, we found that the improving effects of galantamine were prevented by SCH-23390, a dopamine-D1 receptor antagonist, and sulpiride, a dopamine-D2 receptor antagonist. Taken together, our results suggest that these hippocampus-dependent performance in these tasks were impaired by Ab 25À35 infusion as the result of failure of nAChR and dopamine responses, as the hippocampus is involved in the object recognition behavior (Rampon et al, 2000;Hammond et al, 2004) and the contextual fear conditioning (Daumas et al, 2004). These findings provide the first in vivo evidence that galantamine augments dopaminergic neurotransmission within the hippocampus through the allosteric activation of nAChR.…”

Lentiviral Delivery of a Vesicular Glutamate Transporter 1 (VGLUT1)-Targeting Short Hairpin RNA Vector Into the Mouse Hippocampus Impairs Cognition

“…In contrast, ventral lesions can spare spatial memory (Moser et al, 1993) while impairing contextual fear conditioning (Fanselow and Dong, 2010) and attenuating PPI (Bast and Feldon, 2003). Potential contributions of the ventral hippocampus to NOD have yet to be investigated, but this task certainly involves dorsal regions of the mouse hippocampus as temporary inactivation by localized administration of lignocaine into the CA1 region impairs performance, provided that a sufficient long intertrial interval is used (Hammond et al, 2004). This apparent functional differentiation is consistent with changes in afferent and efferent connectivity along the dorsoventral axis of the hippocampus.…”

“…First, nonspatial visual recognition memory was examined using a hippocampal-dependent NOD task (Hammond et al, 2004;Broadbent et al, 2004) based on rodents innate preference for novelty, rather than food reward or negative reinforcement, which therefore involves similar motivational conditions to those under which human memory is normally assessed. Control and VGLUT1-targeting shRNA-treated mice achieved comparable levels of object exploration during the acquisition phase of this task (91.1±6.6 and 74.9±5.3 s, respectively; P40.05) and showed no preference for either of the identical objects (F (1, 14) ¼ 2.281, P40.05; shRNA sequence: F (1, 14) ¼ 3.682, P40.05; interaction: F (1, 14) ¼ 0.069, P40.05; Figure 2a).…”

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

“…Similarly, electrophysiological (Zhu and Brown, 1995;Zhu et al, 1995a) and c-Fos studies (Zhu et al, 1996(Zhu et al, , 1997Wan et al, 1999;Jenkins et al, 2004;Amin et al, 2006) have shown that the perirhinal cortex is recruited more during recognition than spatial tasks and vice versa for the hippocampus. There is mounting evidence to suggest that the hippocampus may indeed play a role in recognition memory (Hammond et al, 2004;Prusky et al, 2004) but the overwhelming consensus is that the perirhinal cortex alone is sufficient for completing recognition memory tasks. A pair of recent reviews compares data from human, non-human primate and rodent studies to argue that the hippocampus may be required more for aspects of recognition memory distinct from pure novelty discrimination such as in tasks that require working spatial and temporal order memory in addition to recognition memory in order to solve them Warburton and Brown, 2010).…”