On the development of a deployable cold plasma endoscope

Winter, J.; Nishime, Thalita Mayumi Castaldelli; Glitsch, S; Lühder, Heike; Weltmann, Klaus‐Dieter

doi:10.1002/ctpp.201700127

Cited by 34 publications

(35 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At least three other plasma systems have been developed by other groups for endoscopy. These include the GREMI group's plasma gun, which targets local cancer therapy with a nanopulsed neon plasma flushed through a capillary that can fit into an endoscope; 18,24,25 Winter et al's 19,26,27 device, which consists of argon CAP delivered through a flexible endoscopy device; and Takamatsu et al's 9 device, which is used for hemostasis in vivo. The system presented in this paper allows the generation of a plasma plume brighter and further away from the plasma source, with the advantage of keeping the high-voltage electrode outside the endoscope and therefore far away from the patient's body.…”

Section: Introductionmentioning

confidence: 99%

Optical and Electrical Characteristics of an Endoscopic DBD Plasma Jet

Bastin¹,

Thulliez²,

Servais³

et al. 2020

Plasma Med

View full text Add to dashboard Cite

In this work, a new cold plasma source design capable of generating and transporting a plasma jet over long distances (2 m) is presented with the purpose of being used in flexible endoscopy for treatment within the gastrointestinal tract. This dielectric barrier discharge helium plasma jet consists of a polytetrafluoroethylene capillary connected to a quartz chamber around which a copper electrode is wrapped. A copper wire is freely inserted inside the capillary. The applied voltage is a conventional AC 18-kHz signal to drive the discharge. In order to develop a safe and predictable treatment, a robust and reliable electrical model is necessary and we hypothesized that plasma transport can be modeled as a transmission line. We therefore assessed the electrical behavior of our new cold plasma source. As it is known that the target to which the plasma jet is applied drastically changes the behavior of the plasma itself, an electrical substitute simulating the impedance of a human body is introduced into the circuit, and the plasma behavior is then compared to the free-jet configuration. The effects of the input power (from 10 W to 80 W), and the length of the jet (from 60 cm to 220 cm) were investigated, as well as the electrical changes induced by the presence of an endoscope. The results obtained show trend curves similar to our hypothetical model, although the latter is still only qualitative. This long plasma jet model represents a promising approach that can be used, after further refinement, for controllability of plasma jets for endoscopy applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Optical and Electrical Characteristics of an Endoscopic DBD Plasma Jet

Bastin¹,

Thulliez²,

Servais³

et al. 2020

Plasma Med

View full text Add to dashboard Cite

show abstract

“…However energetic plasma species (electrons, photons and metastables) interact with air molecules producing reactive oxygen (ROS) and nitrogen (RNS) species that can modify and decontaminate surfaces [5,6]. Since APPJs can generate up to several cm-long plasma plumes they can be adapted to treat irregular 3D objects and also internal surface of narrow tubes or cavities [7]. In most excitation schemes and working gases the plasma plume diameter is slightly wider than the inner diameter of the employed dielectric tube [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

Uniform surface modification of polyethylene terephthalate (PET) by atmospheric pressure plasma jet with a horn-like nozzle

Mui

Mota

Quade

et al. 2018

Surface and Coatings Technology

View full text Add to dashboard Cite

This work reports on surface modification of polyethylene terephthalate (PET) polymer by an atmospheric pressure plasma jet (APPJ) operated with argon. A distinguishable feature of this device is that it terminates with a conical horn-like nozzle. Three different nozzles diameters were employed with the purpose to obtain uniform surface modification over large area. Treatments in small 3D objects that fit inside the conical horn were also conducted. In this study, water contact angle (WCA) measurements and X-ray photoelectron spectroscopy (XPS) were performed to assess the samples wettability and the surface elemental composition, as well as, their radial distribution. Plasma-induced changes on the polymer surface morphology were evaluated by Atomic Force Microscopy (AFM). Electrical characterization of the plasma and investigation of the effect of the gas flow rate on the discharge power were carried out. After the plasma treatment PET surface became more hydrophilic over the entire area covered by the nozzle. This effect is caused by the incorporation of oxygen containing polar groups on the surface. It was also observed that depending on process parameters, the plasma treatment can extend even outside the area of the conical horn. The degree of surface modification depends on plasma dose while the treatment uniformity is determined mostly by the distance to the sample. Overall, a quite uniform surface modification was obtained over the entire area covered by the jet nozzle. Thus, the results suggest that by simply changing the jet geometry and choosing the right treatment parameters one can achieve a uniform treatment over an area whose size is determined by the horn diameter.

show abstract

“…The second CAP device used is shown in Figure 1b,d. This endoscopic plasma source has been described in detail elsewhere [10,11]. In order to treat the complete tissue section with the endoscopic plasma device, the plasma jet was moved across the whole sample (see Figure 1d).…”

Section: Methodsmentioning

confidence: 99%

“…This is particularly true for jet plasma devices, where the point-like plasma flow must be moved evenly and completely over the surface under treatment. In addition, endoscopic CAP devices are under development whose application also requires effective and meaningful therapy monitoring [10,11]. In addition to this basic therapy monitoring, i.e., the highlighting of tissue areas which have been exposed to plasma, there is also a lack of real-time visualization of therapeutic effects for the direct control of plasma treatment processes and their therapeutic consequences.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Nonlinear Microscopy for Therapy Monitoring of Cold Atmospheric Plasma Treatment

et al. 2019

Self Cite

View full text Add to dashboard Cite

Here we report on a non-linear spectroscopic method for visualization of cold atmospheric plasma (CAP)-induced changes in tissue for reaching a new quality level of CAP application in medicine via online monitoring of wound or cancer treatment. A combination of coherent anti-Stokes Raman scattering (CARS), two-photon fluorescence lifetime imaging (2P-FLIM) and second harmonic generation (SHG) microscopy has been used for non-invasive and label-free detection of CAP-induced changes on human skin and mucosa samples. By correlation with histochemical staining, the observed local increase in fluorescence could be assigned to melanin. CARS and SHG prove the integrity of the tissue structure, visualize tissue morphology and composition. The influence of plasma effects by variation of plasma parameters e.g., duration of treatment, gas composition and plasma source has been evaluated. Overall quantitative spectroscopic markers could be identified for a direct monitoring of CAP-treated tissue areas, which is very important for translating CAPs into clinical routine.

show abstract

On the development of a deployable cold plasma endoscope

Cited by 34 publications

References 19 publications

Optical and Electrical Characteristics of an Endoscopic DBD Plasma Jet

Optical and Electrical Characteristics of an Endoscopic DBD Plasma Jet

Uniform surface modification of polyethylene terephthalate (PET) by atmospheric pressure plasma jet with a horn-like nozzle

Multimodal Nonlinear Microscopy for Therapy Monitoring of Cold Atmospheric Plasma Treatment

Contact Info

Product

Resources

About